2.50
Hdl Handle:
http://hdl.handle.net/10033/619855
Title:
Protein homeostasis-more than resisting a hot bath.
Authors:
Lee, Changhan; Wigren, Edvard; Lünsdorf, Heinrich; Römling, Ute
Abstract:
Maintenance of protein homeostasis is essential for survival of all organisms. In bacteria, the protein quality control system has a broad physiological impact beyond heat shock resistance, being involved in virulence, antibiotic resistance, as well as protection against environmental stresses. Its contribution to rejuvenation and growth arrest suggests interference with protein quality control to be a novel antimicrobial strategy. Remarkably, a protein quality control module originating from environmental strains has been found to be horizontally transferred to predominant clonal groups of bacteria providing exquisite thermotolerance to recently emerged global pathogens suggesting that novel features related to protein homeostasis contribute to the transition to new environments.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7,38124 Braunschweig, Germany.
Citation:
Protein homeostasis-more than resisting a hot bath. 2016, 30:147-54 Curr. Opin. Microbiol.
Journal:
Current opinion in microbiology
Issue Date:
Apr-2016
URI:
http://hdl.handle.net/10033/619855
DOI:
10.1016/j.mib.2016.02.006
PubMed ID:
26974352
Type:
Article
Language:
en
ISSN:
1879-0364
Appears in Collections:
publications of the central unit for microscopy (ZEIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, Changhanen
dc.contributor.authorWigren, Edvarden
dc.contributor.authorLünsdorf, Heinrichen
dc.contributor.authorRömling, Uteen
dc.date.accessioned2016-09-05T11:55:06Z-
dc.date.available2016-09-05T11:55:06Z-
dc.date.issued2016-04-
dc.identifier.citationProtein homeostasis-more than resisting a hot bath. 2016, 30:147-54 Curr. Opin. Microbiol.en
dc.identifier.issn1879-0364-
dc.identifier.pmid26974352-
dc.identifier.doi10.1016/j.mib.2016.02.006-
dc.identifier.urihttp://hdl.handle.net/10033/619855-
dc.description.abstractMaintenance of protein homeostasis is essential for survival of all organisms. In bacteria, the protein quality control system has a broad physiological impact beyond heat shock resistance, being involved in virulence, antibiotic resistance, as well as protection against environmental stresses. Its contribution to rejuvenation and growth arrest suggests interference with protein quality control to be a novel antimicrobial strategy. Remarkably, a protein quality control module originating from environmental strains has been found to be horizontally transferred to predominant clonal groups of bacteria providing exquisite thermotolerance to recently emerged global pathogens suggesting that novel features related to protein homeostasis contribute to the transition to new environments.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleProtein homeostasis-more than resisting a hot bath.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7,38124 Braunschweig, Germany.en
dc.identifier.journalCurrent opinion in microbiologyen

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