2.50
Hdl Handle:
http://hdl.handle.net/10033/620134
Title:
Adaptation in CRISPR-Cas Systems.
Authors:
Sternberg, Samuel H; Richter, Hagen; Charpentier, Emmanuelle; Qimron, Udi
Abstract:
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation. During the past 3 years, significant progress has been made on the genetic requirements and molecular mechanisms of adaptation. Here we review these recent advances, with a focus on the experimental approaches that have been developed, the insights they generated, and a proposed mechanism for self- versus non-self-discrimination during the process of spacer selection. We further describe the regulation of adaptation and the protein players involved in this fascinating process that allows bacteria and archaea to harbor adaptive immunity.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Adaptation in CRISPR-Cas Systems. 2016, 61 (6):797-808 Mol. Cell
Journal:
Molecular cell
Issue Date:
17-Mar-2016
URI:
http://hdl.handle.net/10033/620134
DOI:
10.1016/j.molcel.2016.01.030
PubMed ID:
26949040
Type:
Article
Language:
en
ISSN:
1097-4164
Appears in Collections:
publications of the department Regulation of infection

Full metadata record

DC FieldValue Language
dc.contributor.authorSternberg, Samuel Hen
dc.contributor.authorRichter, Hagenen
dc.contributor.authorCharpentier, Emmanuelleen
dc.contributor.authorQimron, Udien
dc.date.accessioned2016-09-14T08:13:12Z-
dc.date.available2016-09-14T08:13:12Z-
dc.date.issued2016-03-17-
dc.identifier.citationAdaptation in CRISPR-Cas Systems. 2016, 61 (6):797-808 Mol. Cellen
dc.identifier.issn1097-4164-
dc.identifier.pmid26949040-
dc.identifier.doi10.1016/j.molcel.2016.01.030-
dc.identifier.urihttp://hdl.handle.net/10033/620134-
dc.description.abstractClustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation. During the past 3 years, significant progress has been made on the genetic requirements and molecular mechanisms of adaptation. Here we review these recent advances, with a focus on the experimental approaches that have been developed, the insights they generated, and a proposed mechanism for self- versus non-self-discrimination during the process of spacer selection. We further describe the regulation of adaptation and the protein players involved in this fascinating process that allows bacteria and archaea to harbor adaptive immunity.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdaptive Immunityen
dc.subject.meshArchaeaen
dc.subject.meshBacteriaen
dc.subject.meshCRISPR-Cas Systemsen
dc.subject.meshClustered Regularly Interspaced Short Palindromic Repeatsen
dc.subject.meshProkaryotic Cellsen
dc.titleAdaptation in CRISPR-Cas Systems.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecular cellen

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