In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium.
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Authors
Alfonso, J C LSchaadt, N S
Schönmeyer, R
Brieu, N
Forestier, G
Wemmert, C
Feuerhake, F
Hatzikirou, H
Issue Date
2016-10-12
Metadata
Show full item recordAbstract
Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or as part of immunosurveillance. In contrast, lymphocytic lobulitis (LLO) is a recurrent inflammation pattern, characterized by lymphoid cells infiltrating lobular structures, that has been associated with increased familial breast cancer risk and immune responses to clinically manifest cancer. The mechanisms and pathogenic implications related to the inflammatory microenvironment in breast tissue are still poorly understood. Currently, the definition of inflammation is mainly descriptive, not allowing a clear distinction of LLO from physiological immunological responses and its role in oncogenesis remains unclear. To gain insights into the prognostic potential of inflammation, we developed an agent-based model of immune and epithelial cell interactions in breast lobular epithelium. Physiological parameters were calibrated from breast tissue samples of women who underwent reduction mammoplasty due to orthopedic or cosmetic reasons. The model allowed to investigate the impact of menstrual cycle length and hormone status on inflammatory responses to cell turnover in the breast tissue. Our findings suggested that the immunological context, defined by the immune cell density, functional orientation and spatial distribution, contains prognostic information previously not captured by conventional diagnostic approaches.Citation
In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium., 6:33322 Sci RepAffiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.Journal
Scientific reportsPubMed ID
27659691Type
ArticleLanguage
en_USISSN
2045-2322ae974a485f413a2113503eed53cd6c53
10.1038/srep33322
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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