2.50
Hdl Handle:
http://hdl.handle.net/10033/620593
Title:
Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase.
Authors:
Neumann, Yvonne; Bruns, Svenja A; Rohde, Manfred; Prajsnar, Tomasz K; Foster, Simon J; Schmitz, Ingo ( 0000-0002-5360-0419 )
Abstract:
Autophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle and survival mechanism during cellular stress, but also as an anti-infective machinery. The human pathogen Staphylococcus aureus (S. aureus) was originally considered solely as an extracellular bacterium, but is now recognized additionally to invade host cells, which might be crucial for persistence. However, the intracellular fate of S. aureus is incompletely understood. Here, we show for the first time induction of selective autophagy by S. aureus infection, its escape from autophagosomes and proliferation in the cytoplasm using live cell imaging. After invasion, S. aureus becomes ubiquitinated and recognized by receptor proteins such as SQSTM1/p62 leading to phagophore recruitment. Yet, S. aureus evades phagophores and prevents further degradation by a MAPK14/p38α MAP kinase-mediated blockade of autophagy. Our study demonstrates a novel bacterial strategy to block autophagy and secure survival inside the host cell.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase. 2016, 12 (11):2069-2084 Autophagy
Journal:
Autophagy
Issue Date:
Nov-2016
URI:
http://hdl.handle.net/10033/620593
DOI:
10.1080/15548627.2016.1226732
PubMed ID:
27629870
Type:
Article
ISSN:
1554-8627
Appears in Collections:
publications of the AG system-oriented immunologyand infection research (SIME)

Full metadata record

DC FieldValue Language
dc.contributor.authorNeumann, Yvonneen
dc.contributor.authorBruns, Svenja Aen
dc.contributor.authorRohde, Manfreden
dc.contributor.authorPrajsnar, Tomasz Ken
dc.contributor.authorFoster, Simon Jen
dc.contributor.authorSchmitz, Ingoen
dc.date.accessioned2016-11-24T11:02:54Z-
dc.date.available2016-11-24T11:02:54Z-
dc.date.issued2016-11-
dc.identifier.citationIntracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase. 2016, 12 (11):2069-2084 Autophagyen
dc.identifier.issn1554-8627-
dc.identifier.pmid27629870-
dc.identifier.doi10.1080/15548627.2016.1226732-
dc.identifier.urihttp://hdl.handle.net/10033/620593-
dc.description.abstractAutophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle and survival mechanism during cellular stress, but also as an anti-infective machinery. The human pathogen Staphylococcus aureus (S. aureus) was originally considered solely as an extracellular bacterium, but is now recognized additionally to invade host cells, which might be crucial for persistence. However, the intracellular fate of S. aureus is incompletely understood. Here, we show for the first time induction of selective autophagy by S. aureus infection, its escape from autophagosomes and proliferation in the cytoplasm using live cell imaging. After invasion, S. aureus becomes ubiquitinated and recognized by receptor proteins such as SQSTM1/p62 leading to phagophore recruitment. Yet, S. aureus evades phagophores and prevents further degradation by a MAPK14/p38α MAP kinase-mediated blockade of autophagy. Our study demonstrates a novel bacterial strategy to block autophagy and secure survival inside the host cell.en
dc.languageENG-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleIntracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase.
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalAutophagyen

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