Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620615
Title:
Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency.
Authors:
Thiele, Carolin; Loretz, Brigitta; Lehr, Claus Michael ( 0000-0002-5864-8462 )
Abstract:
Regioselective oxidation of water-soluble starch and conversion with alkyl diamines resulted in defined cationic starch derivatives. Those were assessed in their potential for polyplex formation, biocompatibility, and transfection efficacy. The new polymers have the advantage of being biodegradable, being not cytotoxic at rather high concentrations (LC50 > 400 μg/ml) for C2 substitution, and reach transfection efficiencies comparable to commercial transfection reagents. The polymer with the highest transfection efficacy is a C12 substituted polymer (degree of substitution = 30 %) at N/P 3. The LC50 value of that highly modified polymer is still one order of magnitude lower than that of PEI 25 kDa.
Affiliation:
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland Universitätscampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency. 2016: Drug Deliv Transl Res
Journal:
Drug delivery and translational research
Issue Date:
3-Oct-2016
URI:
http://hdl.handle.net/10033/620615
DOI:
10.1007/s13346-016-0333-8
PubMed ID:
27699593
Type:
Article
ISSN:
2190-3948
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorThiele, Carolinen
dc.contributor.authorLoretz, Brigittaen
dc.contributor.authorLehr, Claus Michaelen
dc.date.accessioned2016-12-01T09:22:46Z-
dc.date.available2016-12-01T09:22:46Z-
dc.date.issued2016-10-03-
dc.identifier.citationBiodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency. 2016: Drug Deliv Transl Resen
dc.identifier.issn2190-3948-
dc.identifier.pmid27699593-
dc.identifier.doi10.1007/s13346-016-0333-8-
dc.identifier.urihttp://hdl.handle.net/10033/620615-
dc.description.abstractRegioselective oxidation of water-soluble starch and conversion with alkyl diamines resulted in defined cationic starch derivatives. Those were assessed in their potential for polyplex formation, biocompatibility, and transfection efficacy. The new polymers have the advantage of being biodegradable, being not cytotoxic at rather high concentrations (LC50 > 400 μg/ml) for C2 substitution, and reach transfection efficiencies comparable to commercial transfection reagents. The polymer with the highest transfection efficacy is a C12 substituted polymer (degree of substitution = 30 %) at N/P 3. The LC50 value of that highly modified polymer is still one order of magnitude lower than that of PEI 25 kDa.en
dc.languageENG-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleBiodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency.
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalDrug delivery and translational researchen

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