Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620662
Title:
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights.
Authors:
Alfonso, J C L; Köhn-Luque, A; Stylianopoulos, T; Feuerhake, F; Deutsch, A; Hatzikirou, H
Abstract:
Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve tumour blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation induced by blood vessel occlusion/collapse. In contrast, the therapeutic intention of normalising the abnormal tumour vasculature is to improve the efficacy of conventional treatment modalities. Although these strategies have shown therapeutic potential, it remains unclear why they both often fail to control glioma growth. To shed some light on this issue, we propose a mathematical model based on the migration/proliferation dichotomy of glioma cells in order to investigate why vaso-modulatory interventions have shown limited success in terms of tumour clearance. We found the existence of a critical cell proliferation/diffusion ratio that separates glioma responses to vaso-modulatory interventions into two distinct regimes. While for tumours, belonging to one regime, vascular modulations reduce the front speed and increase the infiltration width, for those in the other regime, the invasion speed increases and infiltration width decreases. We discuss how these in silico findings can be used to guide individualised vaso-modulatory approaches to improve treatment success rates.
Affiliation:
Braunschweiger zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.
Citation:
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. 2016, 6:37283 Sci Rep
Journal:
Scientific reports
Issue Date:
23-Nov-2016
URI:
http://hdl.handle.net/10033/620662
DOI:
10.1038/srep37283
PubMed ID:
27876890
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorAlfonso, J C Len
dc.contributor.authorKöhn-Luque, Aen
dc.contributor.authorStylianopoulos, Ten
dc.contributor.authorFeuerhake, Fen
dc.contributor.authorDeutsch, Aen
dc.contributor.authorHatzikirou, Hen
dc.date.accessioned2016-12-12T12:36:32Z-
dc.date.available2016-12-12T12:36:32Z-
dc.date.issued2016-11-23-
dc.identifier.citationWhy one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. 2016, 6:37283 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid27876890-
dc.identifier.doi10.1038/srep37283-
dc.identifier.urihttp://hdl.handle.net/10033/620662-
dc.description.abstractGliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve tumour blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation induced by blood vessel occlusion/collapse. In contrast, the therapeutic intention of normalising the abnormal tumour vasculature is to improve the efficacy of conventional treatment modalities. Although these strategies have shown therapeutic potential, it remains unclear why they both often fail to control glioma growth. To shed some light on this issue, we propose a mathematical model based on the migration/proliferation dichotomy of glioma cells in order to investigate why vaso-modulatory interventions have shown limited success in terms of tumour clearance. We found the existence of a critical cell proliferation/diffusion ratio that separates glioma responses to vaso-modulatory interventions into two distinct regimes. While for tumours, belonging to one regime, vascular modulations reduce the front speed and increase the infiltration width, for those in the other regime, the invasion speed increases and infiltration width decreases. We discuss how these in silico findings can be used to guide individualised vaso-modulatory approaches to improve treatment success rates.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleWhy one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights.en
dc.typeArticleen
dc.contributor.departmentBraunschweiger zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en
dc.identifier.journalScientific reportsen
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