EU-OPENSCREEN-chemical tools for the study of plant biology and resistance mechanisms.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620739
Title:
EU-OPENSCREEN-chemical tools for the study of plant biology and resistance mechanisms.
Authors:
Meiners, Torsten; Stechmann, Bahne; Frank, Ronald
Abstract:
EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the 'hit' compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
EU-OPENSCREEN-chemical tools for the study of plant biology and resistance mechanisms. 2014, 7 (4):113-8 J Chem Biol
Journal:
Journal of chemical biology
Issue Date:
Oct-2014
URI:
http://hdl.handle.net/10033/620739
DOI:
10.1007/s12154-014-0118-9
PubMed ID:
25320643
Type:
Article
Language:
en
ISSN:
1864-6158
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorMeiners, Torstenen
dc.contributor.authorStechmann, Bahneen
dc.contributor.authorFrank, Ronalden
dc.date.accessioned2017-01-23T14:08:52Z-
dc.date.available2017-01-23T14:08:52Z-
dc.date.issued2014-10-
dc.identifier.citationEU-OPENSCREEN-chemical tools for the study of plant biology and resistance mechanisms. 2014, 7 (4):113-8 J Chem Biolen
dc.identifier.issn1864-6158-
dc.identifier.pmid25320643-
dc.identifier.doi10.1007/s12154-014-0118-9-
dc.identifier.urihttp://hdl.handle.net/10033/620739-
dc.description.abstractEU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the 'hit' compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act.en
dc.language.isoenen
dc.titleEU-OPENSCREEN-chemical tools for the study of plant biology and resistance mechanisms.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of chemical biologyen

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