The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae

2.50
Hdl Handle:
http://hdl.handle.net/10033/620752
Title:
The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae
Authors:
Gross, Roy; Guzman, Carlos A; Sebaihia, Mohammed; Martins dos Santos, Vítor A; Pieper, Dietmar H; Koebnik, Ralf; Lechner, Melanie; Bartels, Daniela; Buhrmester, Jens; Choudhuri, Jomuna V; Ebensen, Thomas; Gaigalat, Lars; Herrmann, Stefanie; Khachane, Amit N; Larisch, Christof; Link, Stefanie; Linke, Burkhard; Meyer, Folker; Mormann, Sascha; Nakunst, Diana; Rückert, Christian; Schneiker-Bekel, Susanne; Schulze, Kai; Vorhölter, Frank-Jörg; Yevsa, Tetyana; Engle, Jacquelyn T; Goldman, William E; Pühler, Alfred; Göbel, Ulf B; Goesmann, Alexander; Blöcker, Helmut; Kaiser, Olaf; Martinez-Arias, Rosa
Abstract:
Abstract Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. Results In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. Conclusion The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.
Citation:
BMC Genomics. 2008 Sep 30;9(1):449
Issue Date:
30-Sep-2008
URI:
http://dx.doi.org/10.1186/1471-2164-9-449; http://hdl.handle.net/10033/620752
Type:
Journal Article
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorGross, Royen
dc.contributor.authorGuzman, Carlos Aen
dc.contributor.authorSebaihia, Mohammeden
dc.contributor.authorMartins dos Santos, Vítor Aen
dc.contributor.authorPieper, Dietmar Hen
dc.contributor.authorKoebnik, Ralfen
dc.contributor.authorLechner, Melanieen
dc.contributor.authorBartels, Danielaen
dc.contributor.authorBuhrmester, Jensen
dc.contributor.authorChoudhuri, Jomuna Ven
dc.contributor.authorEbensen, Thomasen
dc.contributor.authorGaigalat, Larsen
dc.contributor.authorHerrmann, Stefanieen
dc.contributor.authorKhachane, Amit Nen
dc.contributor.authorLarisch, Christofen
dc.contributor.authorLink, Stefanieen
dc.contributor.authorLinke, Burkharden
dc.contributor.authorMeyer, Folkeren
dc.contributor.authorMormann, Saschaen
dc.contributor.authorNakunst, Dianaen
dc.contributor.authorRückert, Christianen
dc.contributor.authorSchneiker-Bekel, Susanneen
dc.contributor.authorSchulze, Kaien
dc.contributor.authorVorhölter, Frank-Jörgen
dc.contributor.authorYevsa, Tetyanaen
dc.contributor.authorEngle, Jacquelyn Ten
dc.contributor.authorGoldman, William Een
dc.contributor.authorPühler, Alfreden
dc.contributor.authorGöbel, Ulf Ben
dc.contributor.authorGoesmann, Alexanderen
dc.contributor.authorBlöcker, Helmuten
dc.contributor.authorKaiser, Olafen
dc.contributor.authorMartinez-Arias, Rosaen
dc.date.accessioned2017-01-27T08:26:34Z-
dc.date.available2017-01-27T08:26:34Z-
dc.date.issued2008-09-30en
dc.identifier.citationBMC Genomics. 2008 Sep 30;9(1):449en
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2164-9-449en
dc.identifier.urihttp://hdl.handle.net/10033/620752-
dc.description.abstractAbstract Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. Results In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. Conclusion The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.en
dc.titleThe missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellaeen
dc.typeJournal Articleen
dc.language.rfc3066enen
dc.rights.holderGross et al.en
dc.date.updated2015-09-04T08:29:04Zen
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