Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620810
Title:
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.
Authors:
Shaaban, Saad; Diestel, Randi; Hinkelmann, Bettina; Muthukumar, Yazh; Verma, Rajeshwar P; Sasse, Florenz; Jacob, Claus
Abstract:
Many types of cancer cells are associated with a disturbed intracellular redox balance and oxidative stress (OS). Among the various agents employed to modulate the intracellular redox state of cells, certain redox catalysts containing quinone and chalcogen moieties have shown considerable promise. Passerini multicomponent reaction has been developed for the synthesis of agents combining two, three or even four redox centers in one molecule in a good yield. When incubated with cancer cells these agents inhibited cell proliferation and induced apoptotic cell death. Interestingly, some of these redox active compounds exhibited quite low toxicity with normal cells. The cause was obviously OS, which was reflected by significant decrease in reduced glutathione, subsequently cell cycle arrest and induction of apoptosis.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents. 2012, 58:192-205 Eur J Med Chem
Journal:
European journal of medicinal chemistry
Issue Date:
Dec-2012
URI:
http://hdl.handle.net/10033/620810
DOI:
10.1016/j.ejmech.2012.09.033
PubMed ID:
23124216
Type:
Article
Language:
en
ISSN:
1768-3254
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorShaaban, Saaden
dc.contributor.authorDiestel, Randien
dc.contributor.authorHinkelmann, Bettinaen
dc.contributor.authorMuthukumar, Yazhen
dc.contributor.authorVerma, Rajeshwar Pen
dc.contributor.authorSasse, Florenzen
dc.contributor.authorJacob, Clausen
dc.date.accessioned2017-02-07T13:39:34Z-
dc.date.available2017-02-07T13:39:34Z-
dc.date.issued2012-12-
dc.identifier.citationNovel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents. 2012, 58:192-205 Eur J Med Chemen
dc.identifier.issn1768-3254-
dc.identifier.pmid23124216-
dc.identifier.doi10.1016/j.ejmech.2012.09.033-
dc.identifier.urihttp://hdl.handle.net/10033/620810-
dc.description.abstractMany types of cancer cells are associated with a disturbed intracellular redox balance and oxidative stress (OS). Among the various agents employed to modulate the intracellular redox state of cells, certain redox catalysts containing quinone and chalcogen moieties have shown considerable promise. Passerini multicomponent reaction has been developed for the synthesis of agents combining two, three or even four redox centers in one molecule in a good yield. When incubated with cancer cells these agents inhibited cell proliferation and induced apoptotic cell death. Interestingly, some of these redox active compounds exhibited quite low toxicity with normal cells. The cause was obviously OS, which was reflected by significant decrease in reduced glutathione, subsequently cell cycle arrest and induction of apoptosis.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAntineoplastic Agentsen
dc.subject.meshBiomimetic Materialsen
dc.subject.meshCell Deathen
dc.subject.meshCell Line, Tumoren
dc.subject.meshCell Proliferationen
dc.subject.meshCell Survivalen
dc.subject.meshChalcogensen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshDrug Screening Assays, Antitumoren
dc.subject.meshHuman Umbilical Vein Endothelial Cellsen
dc.subject.meshHumansen
dc.subject.meshMCF-7 Cellsen
dc.subject.meshMolecular Structureen
dc.subject.meshOxidation-Reductionen
dc.subject.meshPeptidesen
dc.subject.meshQuinonesen
dc.subject.meshStructure-Activity Relationshipen
dc.titleNovel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalEuropean journal of medicinal chemistryen

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