Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.

2.50
Hdl Handle:
http://hdl.handle.net/10033/620908
Title:
Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.
Authors:
Elbahesh, Husni; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature. 2016, 6:26437 Sci Rep
Journal:
Scientific reports
Issue Date:
19-May-2016
URI:
http://hdl.handle.net/10033/620908
DOI:
10.1038/srep26437
PubMed ID:
27193691
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorElbahesh, Husnien
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2017-05-05T07:27:21Z-
dc.date.available2017-05-05T07:27:21Z-
dc.date.issued2016-05-19-
dc.identifier.citationGenetically diverse CC-founder mouse strains replicate the human influenza gene expression signature. 2016, 6:26437 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid27193691-
dc.identifier.doi10.1038/srep26437-
dc.identifier.urihttp://hdl.handle.net/10033/620908-
dc.description.abstractInfluenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleGenetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalScientific reportsen

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