2.50
Hdl Handle:
http://hdl.handle.net/10033/620910
Title:
Anti-virulence Strategies to Target Bacterial Infections.
Authors:
Mühlen, Sabrina; Dersch, Petra ( 0000-0001-8177-3280 )
Abstract:
Resistance of important bacterial pathogens to common antimicrobial therapies and the emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute one of our greatest challenges in the combat of bacterial infection and accompanied diseases. The current shortage of effective drugs, lack of successful prevention measures and only a few new antibiotics in the clinical pipeline demand the development of novel treatment options and alternative antimicrobial therapies. Our increasing understanding of bacterial virulence strategies and the induced molecular pathways of the infectious disease provides novel opportunities to target and interfere with crucial pathogenicity factors or virulence-associated traits of the bacteria while bypassing the evolutionary pressure on the bacterium to develop resistance. In the past decade, numerous new bacterial targets for anti-virulence therapies have been identified, and structure-based tailoring of intervention strategies and screening assays for small-molecule inhibitors of such pathways were successfully established. In this chapter, we will take a closer look at the bacterial virulence-related factors and processes that present promising targets for anti-virulence therapies, recently discovered inhibitory substances and their promises and discuss the challenges, and problems that have to be faced.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Anti-virulence Strategies to Target Bacterial Infections. 2016, 398:147-183 Curr. Top. Microbiol. Immunol.
Journal:
Current topics in microbiology and immunology
Issue Date:
2016
URI:
http://hdl.handle.net/10033/620910
DOI:
10.1007/82_2015_490
PubMed ID:
26942418
Type:
Article
Language:
en
ISSN:
0070-217X
Appears in Collections:
publications of the department of molecular Infectionbiology (MIBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorMühlen, Sabrinaen
dc.contributor.authorDersch, Petraen
dc.date.accessioned2017-05-08T11:46:33Z-
dc.date.available2017-05-08T11:46:33Z-
dc.date.issued2016-
dc.identifier.citationAnti-virulence Strategies to Target Bacterial Infections. 2016, 398:147-183 Curr. Top. Microbiol. Immunol.en
dc.identifier.issn0070-217X-
dc.identifier.pmid26942418-
dc.identifier.doi10.1007/82_2015_490-
dc.identifier.urihttp://hdl.handle.net/10033/620910-
dc.description.abstractResistance of important bacterial pathogens to common antimicrobial therapies and the emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute one of our greatest challenges in the combat of bacterial infection and accompanied diseases. The current shortage of effective drugs, lack of successful prevention measures and only a few new antibiotics in the clinical pipeline demand the development of novel treatment options and alternative antimicrobial therapies. Our increasing understanding of bacterial virulence strategies and the induced molecular pathways of the infectious disease provides novel opportunities to target and interfere with crucial pathogenicity factors or virulence-associated traits of the bacteria while bypassing the evolutionary pressure on the bacterium to develop resistance. In the past decade, numerous new bacterial targets for anti-virulence therapies have been identified, and structure-based tailoring of intervention strategies and screening assays for small-molecule inhibitors of such pathways were successfully established. In this chapter, we will take a closer look at the bacterial virulence-related factors and processes that present promising targets for anti-virulence therapies, recently discovered inhibitory substances and their promises and discuss the challenges, and problems that have to be faced.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.titleAnti-virulence Strategies to Target Bacterial Infections.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalCurrent topics in microbiology and immunologyen

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