Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults.
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Authors
Hootman, Katie CTrezzi, Jean-Pierre
Kraemer, Lisa
Burwell, Lindsay S
Dong, Xiangyi
Guertin, Kristin A
Jaeger, Christian
Stover, Patrick J
Hiller, Karsten
Cassano, Patricia A
Issue Date
2017-05-23
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Show full item recordAbstract
Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by phenotype [incident central adiposity, stable adiposity, baseline hemoglobin A1c (HbA1c) > 5.05%, HbA1c < 4.92%] and assayed using GC-MS, chromatograms were analyzed using MetaboliteDetector software, and normalized metabolite levels were compared using Welch's t test. Assays were repeated using freshly prepared pools, and statistically significant metabolites were quantified in a targeted GC-MS approach. Isotope tracer studies were performed to determine if the potential marker was an endogenous human metabolite in men and in whole blood. Participants with incident central adiposity gain had statistically significantly higher blood erythritol [P < 0.001, false discovery rate (FDR) = 0.0435], and the targeted assay revealed 15-fold [95% confidence interval (CI): 13.27, 16.25] higher blood erythritol compared with participants with stable adiposity. Participants with baseline HbA1c > 5.05% had 21-fold (95% CI: 19.84, 21.41) higher blood erythritol compared with participants with lower HbA1c (P < 0.001, FDR = 0.00016). Erythritol was shown to be synthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assisted ex vivo blood incubation experiments and through in vivo conversion of erythritol to erythronate in stable isotope-assisted dried blood spot experiments. Therefore, endogenous production of erythritol from glucose may contribute to the association between erythritol and obesity observed in young adults.Citation
Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. 2017, 114 (21):E4233-E4240 Proc. Natl. Acad. Sci. U.S.A.Affiliation
Helmholtz Centre for infection research, Inhoffenstr.7, 38124 Braunschweig, Germany.PubMed ID
28484010Type
ArticleLanguage
enISSN
1091-6490ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1620079114
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/