Myxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621228
Title:
Myxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat.
Authors:
Mohr, Kathrin I; Zindler, Tanja; Wink, Joachim ( 0000-0001-9675-0276. ) ; Wilharm, Elke; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
Increasing antibiotic resistances of numerous pathogens mean that myxobacteria, well known producers of new antibiotics, are becoming more and more interesting. More than 100 secondary metabolites, most of them with bioactivity, were described from the order Myxococcales. Especially new myxobacterial genera and species turned out to be reliable sources for novel antibiotics and can be isolated from uncommon neglected habitats like, for example, acidic soils. Almost nothing is known about the diversity of myxobacteria in moors, except some information from cultivation studies of the 1970s. Therefore, we evaluated the myxobacterial community composition of acidic high moor and fen both with cultivation-independent 16S rRNA clone bank analysis and with cultivation. Phylogenetic analyses of clone sequences revealed a great potential of undescribed myxobacteria in high moor and fen, whereby all sequences represent unknown taxa and were detected exclusively by cultivation-independent analyses. However, many clones were assigned to sequences from other cultivation-independent studies of eubacterial diversity in acidic habitats. Cultivation revealed different strains exclusively from the genus Corallococcus. Our study shows that the neglected habitat moor is a promising source and of high interest with regard to the cultivation of prospective new bioactive secondary metabolite producing myxobacteria.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Myxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat. 2017, 6 (4) Microbiologyopen
Journal:
MicrobiologyOpen
Issue Date:
Aug-2017
URI:
http://hdl.handle.net/10033/621228
DOI:
10.1002/mbo3.464
PubMed ID:
28401707
PubMed Central ID:
5552953
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552953/
Type:
Article
Language:
en
ISSN:
2045-8827
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorMohr, Kathrin Ien
dc.contributor.authorZindler, Tanjaen
dc.contributor.authorWink, Joachimen
dc.contributor.authorWilharm, Elkeen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2018-01-09T14:53:43Z-
dc.date.available2018-01-09T14:53:43Z-
dc.date.issued2017-08-
dc.identifier.citationMyxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat. 2017, 6 (4) Microbiologyopenen
dc.identifier.issn2045-8827-
dc.identifier.pmid28401707-
dc.identifier.doi10.1002/mbo3.464-
dc.identifier.urihttp://hdl.handle.net/10033/621228-
dc.description.abstractIncreasing antibiotic resistances of numerous pathogens mean that myxobacteria, well known producers of new antibiotics, are becoming more and more interesting. More than 100 secondary metabolites, most of them with bioactivity, were described from the order Myxococcales. Especially new myxobacterial genera and species turned out to be reliable sources for novel antibiotics and can be isolated from uncommon neglected habitats like, for example, acidic soils. Almost nothing is known about the diversity of myxobacteria in moors, except some information from cultivation studies of the 1970s. Therefore, we evaluated the myxobacterial community composition of acidic high moor and fen both with cultivation-independent 16S rRNA clone bank analysis and with cultivation. Phylogenetic analyses of clone sequences revealed a great potential of undescribed myxobacteria in high moor and fen, whereby all sequences represent unknown taxa and were detected exclusively by cultivation-independent analyses. However, many clones were assigned to sequences from other cultivation-independent studies of eubacterial diversity in acidic habitats. Cultivation revealed different strains exclusively from the genus Corallococcus. Our study shows that the neglected habitat moor is a promising source and of high interest with regard to the cultivation of prospective new bioactive secondary metabolite producing myxobacteria.en
dc.language.isoenen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552953/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMyxobacteria in high moor and fen: An astonishing diversity in a neglected extreme habitat.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMicrobiologyOpenen
dc.identifier.pmcid5552953-
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