Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections.
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Authors
Castoldi, AriannaHerr, Christian
Niederstraßer, Julia
Labouta, Hagar Ibrahim
Melero, Ana
Gordon, Sarah
Schneider-Daum, Nicole
Bals, Robert
Lehr, Claus Michael
Issue Date
2017-09
Metadata
Show full item recordAbstract
The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections. In the current study, 25(OH)D was encapsulated in liposomes to enable aerosolisation, and tested for the ability to prevent pulmonary infection by Pseudomonas aeruginosa. Prepared 25(OH)D-loaded liposomes were nanosized and monodisperse, with a negative surface charge and a 25(OH)D entrapment efficiency of approximately 23%. Jet nebulisation of liposomes was seen to yield an aerosol suitable for tracheo-bronchial deposition. Interestingly, 25(OH)D in either liposomes or ethanolic solution had no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells (LA-4); treatment of infected, human bronchial 16-HBE cells with 25(OH)D liposomes however resulted in a significant reduction in bacterial survival. Together with the importance of selecting an application-appropriate in vitro model, the current study illustrates the feasibility and practicality of employing liposomes as a means to achieve 25(OH)D lung deposition. 25(OH)D-loaded liposomes further demonstrated promising effects regarding prevention of Pseudomonas infection in human bronchial epithelial cells.Citation
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. 2017, 118:62-67 Eur J Pharm BiopharmAffiliation
HIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.PubMed ID
27888144Type
ArticleLanguage
enISSN
1873-3441ae974a485f413a2113503eed53cd6c53
10.1016/j.ejpb.2016.11.026
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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