2.50
Hdl Handle:
http://hdl.handle.net/10033/621370
Title:
Tissue maintenance of CMV-specific inflationary memory T cells by IL-15.
Authors:
Baumann, Nicolas S; Torti, Nicole; Welten, Suzanne P M; Barnstorf, Isabel; Borsa, Mariana; Pallmer, Katharina; Oduro, Jennifer D; Cicin-Sain, Luka ( 0000-0003-3978-778X ) ; Ikuta, Koichi; Ludewig, Burkhard; Oxenius, Annette
Abstract:
Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this population depends on recurrent antigen encounter, the requirements for prolonged survival in peripheral tissues remain unknown. Here, we reveal that murine CMV-specific inflationary CD8 T cells are maintained in an antigen-independent manner and have a half-life of 12 weeks in the lung tissue. This half-life is drastically longer than the one of phenotypically comparable inflationary effector cells. IL-15 alone, and none of other common γ-cytokines, was crucial for survival of inflationary cells in peripheral organs. IL-15, mainly produced by non-hematopoietic cells in lung tissue and being trans-presented, promoted inflationary T cell survival by increasing expression of Bcl-2. These results indicate that inflationary CD8 T cells are not just simply effector-like cells, rather they share properties of both effector and memory CD8 T cells and they appear to be long-lived cells compared to the effector cells from acute virus infections.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. 2018, 14 (4):e1006993 PLoS Pathog.
Journal:
PLoS pathogens
Issue Date:
Apr-2018
URI:
http://hdl.handle.net/10033/621370
DOI:
10.1371/journal.ppat.1006993
PubMed ID:
29652930
Type:
Article
Language:
en
ISSN:
1553-7374
Appears in Collections:
publications of the research group immune aging and chronic infections (IMCI)

Full metadata record

DC FieldValue Language
dc.contributor.authorBaumann, Nicolas Sen
dc.contributor.authorTorti, Nicoleen
dc.contributor.authorWelten, Suzanne P Men
dc.contributor.authorBarnstorf, Isabelen
dc.contributor.authorBorsa, Marianaen
dc.contributor.authorPallmer, Katharinaen
dc.contributor.authorOduro, Jennifer Den
dc.contributor.authorCicin-Sain, Lukaen
dc.contributor.authorIkuta, Koichien
dc.contributor.authorLudewig, Burkharden
dc.contributor.authorOxenius, Annetteen
dc.date.accessioned2018-05-14T13:34:51Z-
dc.date.available2018-05-14T13:34:51Z-
dc.date.issued2018-04-
dc.identifier.citationTissue maintenance of CMV-specific inflationary memory T cells by IL-15. 2018, 14 (4):e1006993 PLoS Pathog.en
dc.identifier.issn1553-7374-
dc.identifier.pmid29652930-
dc.identifier.doi10.1371/journal.ppat.1006993-
dc.identifier.urihttp://hdl.handle.net/10033/621370-
dc.description.abstractCytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this population depends on recurrent antigen encounter, the requirements for prolonged survival in peripheral tissues remain unknown. Here, we reveal that murine CMV-specific inflationary CD8 T cells are maintained in an antigen-independent manner and have a half-life of 12 weeks in the lung tissue. This half-life is drastically longer than the one of phenotypically comparable inflationary effector cells. IL-15 alone, and none of other common γ-cytokines, was crucial for survival of inflationary cells in peripheral organs. IL-15, mainly produced by non-hematopoietic cells in lung tissue and being trans-presented, promoted inflationary T cell survival by increasing expression of Bcl-2. These results indicate that inflationary CD8 T cells are not just simply effector-like cells, rather they share properties of both effector and memory CD8 T cells and they appear to be long-lived cells compared to the effector cells from acute virus infections.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleTissue maintenance of CMV-specific inflationary memory T cells by IL-15.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPLoS pathogensen

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