Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621371
Title:
Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.
Authors:
Neumann, Jens; Henneberg, Sophie; von Kenne, Susanne; Nolte, Niklas; Müller, Andreas J; Schraven, Burkhart; Görtler, Michael W; Reymann, Klaus G; Gunzer, Matthias; Riek-Burchardt, Monika
Abstract:
Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo. 2018, 13 (3):e0193970 PLoS ONE
Journal:
PloS one
Issue Date:
2018
URI:
http://hdl.handle.net/10033/621371
DOI:
10.1371/journal.pone.0193970
PubMed ID:
29543836
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the research group intravital microscopy in infection and immunity (INMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorNeumann, Jensen
dc.contributor.authorHenneberg, Sophieen
dc.contributor.authorvon Kenne, Susanneen
dc.contributor.authorNolte, Niklasen
dc.contributor.authorMüller, Andreas Jen
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorGörtler, Michael Wen
dc.contributor.authorReymann, Klaus Gen
dc.contributor.authorGunzer, Matthiasen
dc.contributor.authorRiek-Burchardt, Monikaen
dc.date.accessioned2018-05-14T14:34:02Z-
dc.date.available2018-05-14T14:34:02Z-
dc.date.issued2018-
dc.identifier.citationBeware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo. 2018, 13 (3):e0193970 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid29543836-
dc.identifier.doi10.1371/journal.pone.0193970-
dc.identifier.urihttp://hdl.handle.net/10033/621371-
dc.description.abstractInflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.en
dc.language.isoenen
dc.titleBeware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPloS oneen

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