2.50
HDL Handle:
http://hdl.handle.net/10033/70553
Title:
Host genetic background strongly influences the response to influenza a virus infections.
Authors:
Srivastava, Barkha; Błazejewska, Paulina; Hessmann, Manuela; Bruder, Dunja; Geffers, Robert; Mauel, Susanne; Gruber, Achim D; Schughart, Klaus
Abstract:
The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influence of the genetic background to influenza A H1N1 (PR8) and H7N7 (SC35M) viruses. The seven inbred laboratory strains of mice analyzed exhibited different weight loss kinetics and survival rates after infection with PR8. Two strains in particular, DBA/2J and A/J, showed very high susceptibility to viral infections compared to all other strains. The LD(50) to the influenza virus PR8 in DBA/2J mice was more than 1000-fold lower than in C57BL/6J mice. High susceptibility in DBA/2J mice was also observed after infection with influenza strain SC35M. In addition, infected DBA/2J mice showed a higher viral load in their lungs, elevated expression of cytokines and chemokines, and a more severe and extended lung pathology compared to infected C57BL/6J mice. These findings indicate a major contribution of the genetic background of the host to influenza A virus infections. The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses.
Affiliation:
Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany.
Citation:
Host genetic background strongly influences the response to influenza a virus infections. 2009, 4 (3):e4857 PLoS ONE
Journal:
PloS one
Issue Date:
2009
URI:
http://hdl.handle.net/10033/70553
DOI:
10.1371/journal.pone.0004857
PubMed ID:
19293935
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of Dept. of Experimental Mouse Genetics (EMG)

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSrivastava, Barkha-
dc.contributor.authorBłazejewska, Paulina-
dc.contributor.authorHessmann, Manuela-
dc.contributor.authorBruder, Dunja-
dc.contributor.authorGeffers, Robert-
dc.contributor.authorMauel, Susanne-
dc.contributor.authorGruber, Achim D-
dc.contributor.authorSchughart, Klaus-
dc.date.accessioned2009-06-16T11:45:54Z-
dc.date.available2009-06-16T11:45:54Z-
dc.date.issued2009-
dc.identifier.citationHost genetic background strongly influences the response to influenza a virus infections. 2009, 4 (3):e4857 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid19293935-
dc.identifier.doi10.1371/journal.pone.0004857-
dc.identifier.urihttp://hdl.handle.net/10033/70553-
dc.description.abstractThe genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influence of the genetic background to influenza A H1N1 (PR8) and H7N7 (SC35M) viruses. The seven inbred laboratory strains of mice analyzed exhibited different weight loss kinetics and survival rates after infection with PR8. Two strains in particular, DBA/2J and A/J, showed very high susceptibility to viral infections compared to all other strains. The LD(50) to the influenza virus PR8 in DBA/2J mice was more than 1000-fold lower than in C57BL/6J mice. High susceptibility in DBA/2J mice was also observed after infection with influenza strain SC35M. In addition, infected DBA/2J mice showed a higher viral load in their lungs, elevated expression of cytokines and chemokines, and a more severe and extended lung pathology compared to infected C57BL/6J mice. These findings indicate a major contribution of the genetic background of the host to influenza A virus infections. The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses.en
dc.language.isoenen
dc.titleHost genetic background strongly influences the response to influenza a virus infections.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Mouse Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany.en
dc.identifier.journalPloS oneen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.