Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways

2.50
Hdl Handle:
http://hdl.handle.net/10033/8675
Title:
Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways
Authors:
Sun, Jibin; Daniel, Rolf; Wagner-Döbler, Irene; Zeng, An-Ping ( 0000-0001-9768-7096 )
Abstract:
Background Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extracellular signaling molecules called autoinducers. Recently, it has been proposed that autoinducer-2 (AI-2), a furanosyl borate diester derived from the recycling of S-adenosyl-homocysteine (SAH) to homocysteine, serves as a universal signal for interspecies communication. Results In this study, 138 completed genomes were examined for the genes involved in the synthesis and detection of AI-2. Except for some symbionts and parasites, all organisms have a pathway to recycle SAH, either using a two-step enzymatic conversion by the Pfs and LuxS enzymes or a one-step conversion using SAH-hydrolase (SahH). 51 organisms including most Gamma-, Beta-, and Epsilonproteobacteria, and Firmicutes possess the Pfs-LuxS pathway, while Archaea, Eukarya, Alphaproteobacteria, Actinobacteria and Cyanobacteria prefer the SahH pathway. In all 138 organisms, only the three Vibrio strains had strong, bidirectional matches to the periplasmic AI-2 binding protein LuxP and the central signal relay protein LuxU. The initial two-component sensor kinase protein LuxQ, and the terminal response regulator luxO are found in most Proteobacteria, as well as in some Firmicutes, often in several copies. Conclusions The genomic analysis indicates that the LuxS enzyme required for AI-2 synthesis is widespread in bacteria, while the periplasmic binding protein LuxP is only present in Vibrio strains. Thus, other organisms may either use components different from the AI-2 signal transduction system of Vibrio strains to sense the signal of AI-2, or they do not have such a quorum sensing system at all.
Citation:
BMC Evolutionary Biology 2004 4:36
Publisher:
BioMed Central
Issue Date:
29-Sep-2004
URI:
http://hdl.handle.net/10033/8675
DOI:
10.1186/1471-2148-4-36
PubMed ID:
15456522
PubMed Central ID:
524169
Additional Links:
http://www.biomedcentral.com/1471-2148/4/36; http://creativecommons.org/licenses/by/2.0
Language:
en_US
ISSN:
1471-2148
Appears in Collections:
Publications of Dept. Genome Analysis (GNA)

Full metadata record

DC FieldValue Language
dc.contributor.authorSun, Jibinen_US
dc.contributor.authorDaniel, Rolfen_US
dc.contributor.authorWagner-Döbler, Ireneen_US
dc.contributor.authorZeng, An-Pingen_US
dc.date.accessioned2007-02-20T14:46:07Z-
dc.date.available2004-09-29en_US
dc.date.available2007-02-20T14:46:07Z-
dc.date.issued2004-09-29en_US
dc.identifier.citationBMC Evolutionary Biology 2004 4:36en_US
dc.identifier.issn1471-2148en_US
dc.identifier.pmid15456522en_US
dc.identifier.doi10.1186/1471-2148-4-36en_US
dc.identifier.urihttp://hdl.handle.net/10033/8675-
dc.description.abstractBackground Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extracellular signaling molecules called autoinducers. Recently, it has been proposed that autoinducer-2 (AI-2), a furanosyl borate diester derived from the recycling of S-adenosyl-homocysteine (SAH) to homocysteine, serves as a universal signal for interspecies communication. Results In this study, 138 completed genomes were examined for the genes involved in the synthesis and detection of AI-2. Except for some symbionts and parasites, all organisms have a pathway to recycle SAH, either using a two-step enzymatic conversion by the Pfs and LuxS enzymes or a one-step conversion using SAH-hydrolase (SahH). 51 organisms including most Gamma-, Beta-, and Epsilonproteobacteria, and Firmicutes possess the Pfs-LuxS pathway, while Archaea, Eukarya, Alphaproteobacteria, Actinobacteria and Cyanobacteria prefer the SahH pathway. In all 138 organisms, only the three Vibrio strains had strong, bidirectional matches to the periplasmic AI-2 binding protein LuxP and the central signal relay protein LuxU. The initial two-component sensor kinase protein LuxQ, and the terminal response regulator luxO are found in most Proteobacteria, as well as in some Firmicutes, often in several copies. Conclusions The genomic analysis indicates that the LuxS enzyme required for AI-2 synthesis is widespread in bacteria, while the periplasmic binding protein LuxP is only present in Vibrio strains. Thus, other organisms may either use components different from the AI-2 signal transduction system of Vibrio strains to sense the signal of AI-2, or they do not have such a quorum sensing system at all.en_US
dc.language.isoen_US-
dc.publisherBioMed Centralen_US
dc.relation.urlhttp://www.biomedcentral.com/1471-2148/4/36en_US
dc.relation.urlhttp://creativecommons.org/licenses/by/2.0en_US
dc.rightsCopyright © 2004 Sun et al; licensee BioMed Central Ltd.en_US
dc.titleIs autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathwaysen_US
dc.identifier.pmcid524169en_US
dc.format.digYES-

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