2024-03-29T07:05:51Zhttp://repository.helmholtz-hzi.de/oai/requestoai:repository.helmholtz-hzi.de:10033/6215362019-08-30T11:29:40Zcom_10033_620968col_10033_621277
Smyth, Redmond P
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Negroni, Matteo
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Lever, Andrew M
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Mak, Johnson
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Kenyon, Julia C
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HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.
2018-11-05T14:31:57Z
2018-11-05T14:31:57Z
2018-01-01
1664-3224
30283444
10.3389/fimmu.2018.02097
http://hdl.handle.net/10033/621536
The central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances in next generation sequencing technology, bioinformatics, and non-coding RNA biology have highlighted the many important roles of RNA in virtually every biological process. Our understanding of RNA biology has been further enriched by a number of significant advances in probing RNA structures. It is now appreciated that many cellular and viral biological processes are highly dependent on specific RNA structures and/or sequences, and such reliance will undoubtedly impact on the evolution of both hosts and viruses. As a contribution to this special issue on host immunity and virus evolution, it is timely to consider how RNA sequences and structures could directly influence the co-evolution between hosts and viruses. In this manuscript, we begin by stating some of the basic principles of RNA structures, followed by describing some of the critical RNA structures in both viruses and hosts. More importantly, we highlight a number of available new tools to predict and to evaluate novel RNA structures, pointing out some of the limitations readers should be aware of in their own analyses.
Attribution-NonCommercial-ShareAlike 3.0 United States
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
RNA structure
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immune evasion
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secondary structure
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viral RNA
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viral evolution
39d5b9fb-f3f9-4e4a-9d92-13c587acfbea
RNA Structure-A Neglected Puppet Master for the Evolution of Virus and Host Immunity.
Article
Frontiers in immunology
2018-11-05T14:31:57Z
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oai:repository.helmholtz-hzi.de:10033/6230812021-10-28T03:21:54Zcom_10033_620968col_10033_621277
Ye, Liqing
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Ambi, Uddhav B
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Olguin-Nava, Marco
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Gribling-Burrer, Anne-Sophie
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Ahmad, Shazeb
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Bohn, Patrick
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Weber, Melanie M
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Smyth, Redmond P
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HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.
2021-10-27T12:31:59Z
2021-10-27T12:31:59Z
2021-09-08
Viruses. 2021 Sep 8;13(9):1788. doi: 10.3390/v13091788.
34578369
10.3390/v13091788
http://hdl.handle.net/10033/623081
1999-4915
Viruses
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.
en
MDPI
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
RNA
RNA structure
RNA virus
evolution
genome packaging
viral assembly
RNA Structures and Their Role in Selective Genome Packaging.
Article
13
9
Viruses
Switzerland
2021-10-27T12:32:00Z
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