2024-03-29T05:52:14Zhttp://repository.helmholtz-hzi.de/oai/requestoai:repository.helmholtz-hzi.de:10033/2114102019-08-30T11:33:05Zcom_10033_211390col_10033_211409
Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma.
von Jagwitz, Marie
Pessler, Frank
Akmatov, Manas
Li, Jialiang
Range, Ursula
Vogelberg, Christian
Division of Pediatric Pulmonology and Allergology, University Children's Hospital, Dresden, Germany.
Asthma
Breath Tests
Child, Preschool
Exhalation
Female
Humans
Hydrogen-Ion Concentration
Hypersensitivity, Immediate
Infant
Male
ROC Curve
Respiratory Sounds
Risk Factors
Sensitivity and Specificity
Early noninvasive detection of increased risk of asthma with exhaled breath condensate (EBC) pH measurement has not been applied to preschool children.
2012-02-20T10:43:37Z
2012-02-20T10:43:37Z
2011-07
Article
Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma. 2011, 128 (1):50-5 J. Allergy Clin. Immunol.
1097-6825
21458041
10.1016/j.jaci.2011.03.005
http://hdl.handle.net/10033/211410
The Journal of allergy and clinical immunology
en
oai:repository.helmholtz-hzi.de:10033/2145922019-08-30T11:25:11Zcom_10033_211390col_10033_211409
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.
Kukita, Akiko
Kukita, Toshio
Nagata, Kengo
Teramachi, Junpei
Li, Yin-Ji
Yoshida, Hiroki
Miyamoto, Hiroshi
Gay, Steffen
Pessler, Frank
Shobuike, Takeo
Department of Microbiology, Faculty of Medicine, Saga University, Saga, Japan. kukita@cc.saga-u.ac.jp
Animals
Arthritis, Experimental
Arthritis, Rheumatoid
Bone Density
Bone and Bones
Cell Differentiation
DNA-Binding Proteins
Female
Humans
Macrophages
Male
Mice
Mice, Transgenic
Osteoblasts
Osteoclasts
RANK Ligand
Rats
Transcription Factors
Since transcription factors expressed in osteoclasts are possible targets for regulation of bone destruction in bone disorders, we investigated the expression of the transcription factor FBI-1/OCZF/LRF (in humans, factor that binds to inducer of short transcripts of human immunodeficiency virus type 1; in rats, osteoclast-derived zinc finger; in mice, leukemia/lymphoma-related factor) in patients with rheumatoid arthritis (RA), and assessed its role in osteoclastogenesis in vivo.
2012-03-07T10:39:20Z
2012-03-07T10:39:20Z
2011-09
Article
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. 2011, 63 (9):2744-54 Arthritis Rheum.
1529-0131
21590684
10.1002/art.30455
http://hdl.handle.net/10033/214592
Arthritis and rheumatism
en
oai:repository.helmholtz-hzi.de:10033/2676342019-08-30T11:25:43Zcom_10033_267632com_10033_211390col_10033_267633
Health-related locus of control and health behaviour among university students in North Rhine Westphalia, Germany.
Helmer, Stefanie M
Krämer, Alexander
Mikolajczyk, Rafael
Bremen Institute for Epidemiology and Prevention Research, University of Bremen, Bremen, Germany. rafael.mikolajczyk@helmholtz-hzi.de.
ABSTRACT:
2013-01-30T09:07:27Z
2013-01-30T09:07:27Z
2012
Article
Health-related locus of control and health behaviour among university students in North Rhine Westphalia, Germany. 2012, 5:703 BMC Res Notes
1756-0500
23273039
10.1186/1756-0500-5-703
http://hdl.handle.net/10033/267634
BMC research notes
en
Archived with thanks to BMC research notes
oai:repository.helmholtz-hzi.de:10033/2723322019-08-30T11:28:22Zcom_10033_211390col_10033_211409
Availability of indicators of migration in the surveillance of HIV, tuberculosis and hepatitis B in the European Union – a short note
Akmatov, Manas K
Mikolajczyk, Rafael
Krumkamp, Ralf
Wörmann, Tanja
Chu, Janet JunQing
Paetzelt, Gunnar
Reintjes, Ralf
Pessler, Frank
Krämer, Alexander
Department of Public Health Medicine, School of Public Health, University of Bielefeld, Bielefeld, Germany
2013-03-14T10:26:47Z
2013-03-14T10:26:47Z
2012-10
2011-07-18
Article
Availability of indicators of migration in the surveillance of HIV, tuberculosis and hepatitis B in the European Union – a short note 2012, 20 (5):483 Journal of Public Health
0943-1853
1613-2238
10.1007/s10389-011-0488-1
http://hdl.handle.net/10033/272332
Journal of Public Health
http://www.springerlink.com/index/10.1007/s10389-011-0488-1
Archived with thanks to Journal of Public Health
Springer
oai:repository.helmholtz-hzi.de:10033/2885952019-08-30T11:32:41Zcom_10033_267632com_10033_211390col_10033_267633
Comorbidities in ADHD children treated with methylphenidate: a database study.
Kraut, Angela A
Langner, Ingo
Lindemann, Christina
Banaschewski, Tobias
Petermann, Ulrike
Petermann, Franz
Mikolajczyk, Rafael
Garbe, Edeltraut
Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Methylphenidate (MPH) is the most common drug treatment of attention deficit / hyperactivity disorder (ADHD) in children. Treatment with MPH is contraindicated in the presence of certain psychiatric, cerebro- and cardiovascular conditions. We assessed MPH treatment prevalence and incidence and the frequency of comorbid conditions related to these contraindications in new MPH users compared to a control group without ADHD and ADHD medication.
2013-05-07T12:45:54Z
2013-05-07T12:45:54Z
2013
Article
Comorbidities in ADHD children treated with methylphenidate: a database study. 2013, 13:11 BMC Psychiatry
1471-244X
23294623
10.1186/1471-244X-13-11
http://hdl.handle.net/10033/288595
BMC psychiatry
en
Archived with thanks to BMC psychiatry
oai:repository.helmholtz-hzi.de:10033/2935832019-08-30T11:33:29Zcom_10033_267632com_10033_211390col_10033_267633
Regional variation in caesarean deliveries in Germany and its causes.
Mikolajczyk, Rafael
Schmedt, Niklas
Zhang, Jun
Lindemann, Christina
Langner, Ingo
Garbe, Edeltraut
Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany. Rafael.mikolajczyk@helmholtz-hzi.de.
Determinants of regional variation in caesarean sections can contribute explanations for the observed overall increasing trend of caesarean sections. We assessed which mechanism explains the higher rate of caesarean sections in the former West than East Germany: a more liberal use of caesarean sections in the case of relative indications or more common caesarean sections without indications.
2013-06-07T12:41:50Z
2013-06-07T12:41:50Z
2013
Article
Regional variation in caesarean deliveries in Germany and its causes. 2013, 13:99 BMC Pregnancy Childbirth
1471-2393
23634820
10.1186/1471-2393-13-99
http://hdl.handle.net/10033/293583
BMC pregnancy and childbirth
en
Archived with thanks to BMC pregnancy and childbirth
oai:repository.helmholtz-hzi.de:10033/3014302019-08-30T11:35:39Zcom_10033_267632com_10033_211390col_10033_267633
Evaluation of pregnancy outcome records in the German Pharmacoepidemiological Research Database (GePaRD).
Mikolajczyk, Rafael
Kraut, Aa
Garbe, E
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; Helmholtz Centre for Infection Research, Braunschweig, Germany; Medical School Hannover, Hannover, Germany.
Routine health care data are a valuable source for the assessment of risks of drugs during pregnancy. Therefore, the aim of the current analysis was the evaluation of pregnancy outcome records in German health insurance data.
2013-09-11T09:51:27Z
2013-09-11T09:51:27Z
2013-08
Article
Evaluation of pregnancy outcome records in the German Pharmacoepidemiological Research Database (GePaRD). 2013, 22 (8):873-80 Pharmacoepidemiol Drug Saf
1099-1557
23733705
10.1002/pds.3467
http://hdl.handle.net/10033/301430
Pharmacoepidemiology and drug safety
en
Archived with thanks to Pharmacoepidemiology and drug safety
oai:repository.helmholtz-hzi.de:10033/3021982019-08-30T11:37:00Zcom_10033_211390col_10033_211409
Serological Evidence of Asymptomatic Infections during Escherichia coli O104:H4 Outbreak in Germany in 2011.
Balabanova, Yanina
Klar, Stefanie
Deleré, Yvonne
Wilking, Hendrik
Faber, Mirko S
Lassen, Sofie Gillesberg
Gilsdorf, Andreas
Dupke, Susann
Nitschke, Martin
Sayk, Friedhelm
Grunow, Roland
Krause, Gerard
Robert Koch Institute, Berlin, Germany.
The largest known outbreak caused by a rare hybrid strain of Shiga toxin-producing E.coli (STEC) and enteroaggregative E. coli (EAEC) (E.coli O104:H4) of serotype O104:H4 occurred in Germany in 2011. Fenugreek sprouts acted as a transmission vehicle and were widely consumed in the outbreak area at the time of the epidemic. In total 3,842 people developed a clinical illness caused by this strain; however the rates of asymptomatic infections remain unclear. We aimed to develop a serological assay for detection of E.coli O104 LPS specific antibodies and to establish the post-outbreak levels of seropositivity among people with documented exposure to contaminated sprouts.
2013-09-24T13:28:54Z
2013-09-24T13:28:54Z
2013
Article
Serological Evidence of Asymptomatic Infections during Escherichia coli O104:H4 Outbreak in Germany in 2011. 2013, 8 (9):e73052 PLoS ONE
1932-6203
24039858
10.1371/journal.pone.0073052
http://hdl.handle.net/10033/302198
PloS one
en
Archived with thanks to PloS one
oai:repository.helmholtz-hzi.de:10033/3045712019-08-30T11:37:00Zcom_10033_267632com_10033_211390col_10033_267633col_10033_267633
Twin and sibling studies using health insurance data: the example of attention deficit/hyperactivity disorder (ADHD).
Langner, Ingo
Garbe, Edeltraut
Banaschewski, Tobias
Mikolajczyk, Rafael
Department of Clinical Epidemiology, Leibniz-Institute for Prevention Research and Epidemiology, BIPS GmbH, Bremen, Germany.
Twin studies are used to assess the contribution of genetic factors to the aetiology of diseases. To show the feasibility of such research on the basis of health insurance data, we analysed twin and sibling data on the attention deficit/hyperactivity disorder (ADHD) in the German Pharmacoepidemiological Research Database (GePaRD).
2013-10-24T11:04:05Z
2013-10-24T11:04:05Z
2013
Article
Twin and sibling studies using health insurance data: the example of attention deficit/hyperactivity disorder (ADHD). 2013, 8 (4):e62177 PLoS ONE
1932-6203
23637997
10.1371/journal.pone.0062177
http://hdl.handle.net/10033/304571
PloS one
en
Archived with thanks to PloS one
oai:repository.helmholtz-hzi.de:10033/3056812019-08-30T11:37:00Zcom_10033_267632com_10033_211390col_10033_267633
Incidence, prevalence, and antithrombotic management of atrial fibrillation in elderly Germans.
Ohlmeier, Christoph
Mikolajczyk, Rafael T
Haverkamp, Wilhelm
Garbe, Edeltraut
Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstraße 30, D - 28359 Bremen, Germany.
Data on the epidemiology of atrial fibrillation (AF) and its antithrombotic management in elderly populations are scarce. The aims of this study were to estimate the incidence and prevalence of AF in the elderly in Germany and to describe antithrombotic management of AF cases.
2013-11-22T12:09:00Z
2013-11-22T12:09:00Z
2013-10
Article
Incidence, prevalence, and antithrombotic management of atrial fibrillation in elderly Germans. 2013, 15 (10):1436-44 Europace
1532-2092
23487542
10.1093/europace/eut048
http://hdl.handle.net/10033/305681
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
en
Archived with thanks to Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
oai:repository.helmholtz-hzi.de:10033/3060852019-08-30T11:27:16Zcom_10033_267632com_10033_211390col_10033_267633
Changes in incidence of anogenital warts diagnoses after the introduction of human papillomavirus vaccination in Germany-an ecologic study.
Mikolajczyk, Rafael
Kraut, Angela A
Horn, Johannes
Schulze-Rath, Renate
Garbe, Edeltraut
BIPS-Institute for Epidemiology and Prevention Research, Bremen, Germany. miko@bips.uni-bremen.de
Adolescent
Adult
Age Distribution
Aged
Alphapapillomavirus
Child
Cohort Studies
Condylomata Acuminata
Databases, Factual
Female
Germany
Humans
Incidence
Male
Middle Aged
Papillomavirus Vaccines
Poisson Distribution
Sex Distribution
Time Factors
Vaccination
Young Adult
In a large health insurance database in Germany, incidence of anogenital warts among 15- to 19-year-old females decreased from 316/100,000 person-years in 2007 to 242 in 2008 (23% reduction, P = 0.0001). The decrease started between the first and second quarter of 2007 (human papillomavirus vaccination was introduced in March 2007).
2013-12-02T12:07:50Z
2013-12-02T12:07:50Z
2013-01
Article
Changes in incidence of anogenital warts diagnoses after the introduction of human papillomavirus vaccination in Germany-an ecologic study. 2013, 40 (1):28-31 Sex Transm Dis
1537-4521
23250300
10.1097/OLQ.0b013e3182756efd
http://hdl.handle.net/10033/306085
Sexually transmitted diseases
en
Archived with thanks to Sexually transmitted diseases
oai:repository.helmholtz-hzi.de:10033/3116172019-08-30T11:25:11Zcom_10033_211390col_10033_211409
Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia.
Karch, André
Manthey, Henrike
Ponto, Claudia
Hermann, Peter
Heinemann, Uta
Schmidt, Christian
Zerr, Inga
Since more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio (QAlb) in a large cohort of patients with different types of dementia.
2014-01-21T13:24:20Z
2014-01-21T13:24:20Z
2013
Article
Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia. 2013, 8 (12):e84405 PLoS ONE
1932-6203
24386372
10.1371/journal.pone.0084405
http://hdl.handle.net/10033/311617
PloS one
en
Archived with thanks to PloS one
oai:repository.helmholtz-hzi.de:10033/3213072019-08-30T11:30:58Zcom_10033_211390col_10033_211409
Epidemiology and cost of herpes zoster and postherpetic neuralgia in Germany.
Ultsch, Bernhard
Köster, Ingrid
Reinhold, Thomas
Siedler, Anette
Krause, Gerard
Icks, Andrea
Schubert, Ingrid
Wichmann, Ole
Epidemiology, Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
After acquiring a varicella virus infection, the virus can reactivate and cause herpes zoster (HZ)--a painful skin rash. A complication of HZ is long-term persistence of pain after the rash has resolved (so-called postherpetic neuralgia, PHN). We aimed to describe the epidemiology of HZ/PHN and to estimate HZ/PHN-related costs in the German statutory health insurance (SHI) system (~85% of the total population). Treatment data of one large SHI was utilized, containing data on approximately 240,000 insured and their utilisation of services in 2004-2009. Identification of HZ- and PHN-cases was performed based on 'International Statistical Classification of Diseases' and specific medications using a control-group design. Incidences per 1,000 person-years (PY) and cost-of-illness for 1 year following HZ-onset considering the payer and societal perspective were calculated. All amounts were inflated to 2010 Euros. Population-figures were standardised and extrapolated to the total SHI-population in Germany in 2010. A mean annual incidence of 5.79 HZ-cases per 1,000 PY was observed, translating into an estimated 403,625 HZ-cases per year in the total SHI-population. Approximately 5% of HZ-cases developed PHN. One HZ-case caused on average euro 210 and euro 376 of costs from the payer and societal perspective, respectively. The development of PHN generated additional costs of euro 1,123 (euro 1,645 societal perspective). Total annual HZ/PHN-related costs were estimated at euro 182 million (euro 105 million) to society (payer). HZ and PHN place a considerable burden on the German SHI-system. Since HZ-vaccines will soon be available, a health-economic evaluation of these vaccines should be conducted.
2014-06-12T14:54:07Z
2014-06-12T14:54:07Z
2013-12
Article
Epidemiology and cost of herpes zoster and postherpetic neuralgia in Germany. 2013, 14 (6):1015-26 Eur J Health Econ
1618-7601
23271349
10.1007/s10198-012-0452-1
http://hdl.handle.net/10033/321307
The European journal of health economics : HEPAC : health economics in prevention and care
en
Archived with thanks to The European journal of health economics : HEPAC : health economics in prevention and care
oai:repository.helmholtz-hzi.de:10033/3220692019-08-30T11:30:52Zcom_10033_267632com_10033_211390col_10033_267633
Autoimmune thyroiditis as a risk factor for stroke: A historical cohort study
Karch, André
Thomas, S. L.
Research group epidemiological and statistical methods, Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany
2014-06-20T13:39:33Z
2014-06-20T13:39:33Z
2014-06-20
Article
Autoimmune thyroiditis as a risk factor for stroke: A historical cohort study 2014, 82 (18):1643 Neurology
0028-3878
1526-632X
10.1212/WNL.0000000000000377
http://hdl.handle.net/10033/322069
Neurology
http://www.neurology.org/cgi/doi/10.1212/WNL.0000000000000377
Archived with thanks to Neurology
oai:repository.helmholtz-hzi.de:10033/3254092019-08-30T11:36:05Zcom_10033_211390col_10033_211409
Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools.
Harder, Thomas
Takla, Anja
Rehfuess, Eva
Sánchez-Vivar, Alex
Matysiak-Klose, Dorothea
Eckmanns, Tim
Krause, Gerard
de Carvalho Gomes, Helena
Jansen, Andreas
Ellis, Simon
Forland, Frode
James, Roberta
Meerpohl, Joerg J
Morgan, Antony
Schünemann, Holger
Zuiderent-Jerak, Teun
Wichmann, Ole
The Project on a Framework for Rating Evidence in Public Health (PRECEPT) was initiated and is being funded by the European Centre for Disease Prevention and Control (ECDC) to define a methodology for evaluating and grading evidence and strength of recommendations in the field of public health, with emphasis on infectious disease epidemiology, prevention and control. One of the first steps was to review existing quality appraisal tools (QATs) for individual research studies of various designs relevant to this area, using a question-based approach.
2014-08-27T11:40:38Z
2014-08-27T11:40:38Z
2014
Article
Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools. 2014, 14:69 BMC Med Res Methodol
1471-2288
24886571
10.1186/1471-2288-14-69
http://hdl.handle.net/10033/325409
BMC medical research methodology
en
Archived with thanks to BMC medical research methodology
oai:repository.helmholtz-hzi.de:10033/3363332019-08-30T11:36:33Zcom_10033_267632com_10033_211390col_10033_267633
Diagnostic profiles of patients with late-onset Creutzfeldt-Jakob disease differ from those of younger Creutzfeldt-Jakob patients: a historical cohort study using data from the German National Reference Center.
Karch, André
Raddatz, Lena Maria
Ponto, Claudia
Hermann, Peter
Summers, David
Zerr, Inga
Department of Neurology, National Reference Center for TSE, Clinical Dementia Center, University Medical School Göttingen, Göttingen, Germany, andre.karch@helmholtz-hzi.de.
In contrast to other neurodegenerative diseases, sporadic Creutzfeldt-Jakob disease (sCJD) is rarely diagnosed in patients older than 75 years. Data describing the characteristics of sCJD in the very old are rare and inconclusive. Therefore, a historical cohort study was designed to evaluate clinical, cerebrospinal fluid (CSF), electroencephalography (EEG), and magnetic resonance imaging (MRI) features of this group. Patients older than 75 years identified via the German surveillance program from 2001 to 2012 (n = 73) were compared to a random subsample of sCJD patients younger than 75 (n = 73) from the same time period using an historical cohort design. Older patients showed a faster disease progression represented by an earlier point of diagnosis and a shorter survival time (p < 0.001). In the early stages of disease, older patients presented slightly more often with dementia (p = 0.127) or dysarthria (p = 0.238), whereas disorders of the extrapyramidal (p = 0.056) and visual system (p = 0.015) were more common in the younger group. Atypical MRI profiles such as MRI lesions restricted to one hemisphere (p < 0.001) or cortical lesions only (p = 0.258) were found more frequently in patients older than 75 years, whereas typical cortical and basal ganglia hyperintensities were more common in the younger group (p = 0.001). We demonstrated for the first time that patients with late-onset sCJD differ from younger sCJD patients with respect to MRI profiles and initial clinical presentation, but not among CSF markers. Misclassification of Creutzfeldt-Jakob disease cases in patients older than 75 years seems likely due to atypical clinical and radiological presentation. This might contribute to lower sCJD incidence rates in this age group.
2014-11-28T15:56:24Z
2014-11-28T15:56:24Z
2014-05
Article
Diagnostic profiles of patients with late-onset Creutzfeldt-Jakob disease differ from those of younger Creutzfeldt-Jakob patients: a historical cohort study using data from the German National Reference Center. 2014, 261 (5):877-83 J. Neurol.
1432-1459
24570280
10.1007/s00415-014-7283-1
http://hdl.handle.net/10033/336333
Journal of neurology
en
oai:repository.helmholtz-hzi.de:10033/3386222019-08-30T11:36:05Zcom_10033_211390col_10033_211409
Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany.
Mehraj, Jaishri
Akmatov, Manas K
Strömpl, Julia
Gatzemeier, Anja
Layer, Franziska
Werner, Guido
Pieper, Dietmar H
Medina, Eva
Witte, Wolfgang
Pessler, Frank
Krause, Gerard
The findings from truly randomized community-based studies on Staphylococcus aureus nasal colonization are scarce. Therefore we have examined point prevalence and risk factors of S. aureus nasal carriage in a non-hospitalized population of Braunschweig, northern Germany.
2015-01-22T12:12:41Z
2015-01-22T12:12:41Z
2014
Article
Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany. 2014, 9 (9):e107937 PLoS ONE
1932-6203
25251407
10.1371/journal.pone.0107937
http://hdl.handle.net/10033/338622
PloS one
en
oai:repository.helmholtz-hzi.de:10033/3387252019-08-30T11:36:05Zcom_10033_267632com_10033_211390col_10033_267633
Evaluating methods for intersectoral comparison of quality of care. A routine data analysis of elective percutaneous coronary interventions.
Ohlmeier, C
Linder, R
Enders, D
Mikolajczyk, Rafael
Haverkamp, W
Horenkamp-Sonntag, D
Garbe, E
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstraße 30, 28359 Bremen, Germany.
To compare the quality of care regarding the use of elective percutaneous coronary interventions (PCIs) in the inpatient and outpatient setting and to evaluate different methods of confounder control in this context.
2015-01-23T13:56:55Z
2015-01-23T13:56:55Z
2014
Article
Evaluating methods for intersectoral comparison of quality of care. A routine data analysis of elective percutaneous coronary interventions. 2014, 53 (4):269-77 Methods Inf Med
0026-1270
25077437
10.3414/ME13-01-0132
http://hdl.handle.net/10033/338725
Methods of information in medicine
en
oai:repository.helmholtz-hzi.de:10033/3440442019-08-30T11:36:05Zcom_10033_267632com_10033_211390col_10033_267633
Trajectories of injecting behavior in the Amsterdam Cohort Study among drug users.
Mikolajczyk, Rafael
Horn, Johannes
Prins, Maria
Wiessing, Lucas
Kretzschmar, Mirjam
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Injecting frequency among people who inject drugs (IDU) can change along distinct trajectories, which can reflect on incidence of HIV and HCV infections. We aimed at assessing these patterns of longitudinal changes, their predictors and their association with the incidence of HIV and HCV.
2015-02-02T15:37:46Z
2015-02-02T15:37:46Z
2014-11-01
Article
Trajectories of injecting behavior in the Amsterdam Cohort Study among drug users. 2014, 144:141-7 Drug Alcohol Depend
1879-0046
25248472
10.1016/j.drugalcdep.2014.08.020
http://hdl.handle.net/10033/344044
Drug and alcohol dependence
en
oai:repository.helmholtz-hzi.de:10033/3440822019-08-30T11:31:20Zcom_10033_267632com_10033_211390col_10033_267633
Standardized surveillance of prion diseases in resource-poor settings is crucial for individual patient-care as well as for decision-making of healthcare authorities.
Karch, André
2015-02-03T13:54:04Z
2015-02-03T13:54:04Z
2015-01
Article
Standardized surveillance of prion diseases in resource-poor settings is crucial for individual patient-care as well as for decision-making of healthcare authorities. 2015, 6 (1):4-5 J Neurosci Rural Pract
0976-3147
25552842
10.4103/0976-3147.143164
http://hdl.handle.net/10033/344082
Journal of neurosciences in rural practice
en
oai:repository.helmholtz-hzi.de:10033/3468732019-08-30T11:36:32Zcom_10033_267632com_10033_211390col_10033_267633
Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study.
Maier, Ilko L
Karch, André
Mikolajczyk, Rafael
Bähr, Mathias
Liman, Jan
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Infections are a frequent cause for prolonged hospitalization and increased mortality after stroke. Recent studies revealed a stroke-induced depression of the peripheral immune system associated with an increased susceptibility for infections. In a mice model for stroke, this immunosuppressive effect was reversible after beta-blocker administration. The aim of our study was to investigate the effect of beta-blocker therapy on the risk of infections and death after stroke in humans.
2015-03-19T13:02:11Z
2015-03-19T13:02:11Z
2015
Article
Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study. 2015, 10 (2):e0116836 PLoS ONE
1932-6203
25643360
10.1371/journal.pone.0116836
http://hdl.handle.net/10033/346873
PloS one
en
oai:repository.helmholtz-hzi.de:10033/5569452019-08-30T11:26:42Zcom_10033_267632com_10033_211390col_10033_267633
Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries.
Damm, Oliver
Ultsch, Bernhard
Horn, Johannes
Mikolajczyk, Rafael
Greiner, Wolfgang
Wichmann, Ole
A systematic review was conducted to assess the cost-effectiveness of routine varicella and herpes zoster (HZ) vaccination in high-income countries estimated by modelling studies.
2015-06-15T14:44:32Z
2015-06-15T14:44:32Z
2015
Article
Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries. 2015, 15:533 BMC Public Health
1471-2458
26041469
10.1186/s12889-015-1861-8
http://hdl.handle.net/10033/556945
BMC public health
en
oai:repository.helmholtz-hzi.de:10033/5584812019-08-30T11:28:51Zcom_10033_211390col_10033_211409
Towards a framework for evaluating and grading evidence in public health.
Harder, Thomas
Abu Sin, Muna
Bosch-Capblanch, Xavier
Bruno Coignard
de Carvalho Gomes, Helena
Duclos, Phillippe
Eckmanns, Tim
Elder, Randy
Ellis, Simon
Forland, Frode
Garner, Paul
James, Roberta
Jansen, Andreas
Krause, Gerard
Lévy-Bruhl, Daniel
Morgan, Antony
Meerpohl, Joerg J
Norris, Susan
Rehfuess, Eva
Sánchez-Vivar, Alex
Schünemann, Holger
Takla, Anja
Wichmann, Ole
Zingg, Walter
Zuiderent-Jerak, Teun
Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
The Project on a Framework for Rating Evidence in Public Health (PRECEPT) is an international collaboration of public health institutes and universities which has been funded by the European Centre for Disease Prevention and Control (ECDC) since 2012. Main objective is to define a framework for evaluating and grading evidence in the field of public health, with particular focus on infectious disease prevention and control. As part of the peer review process, an international expert meeting was held on 13-14 June 2013 in Berlin. Participants were members of the PRECEPT team and selected experts from national public health institutes, World Health Organization (WHO), and academic institutions. The aim of the meeting was to discuss the draft framework and its application to two examples from infectious disease prevention and control. This article introduces the draft PRECEPT framework and reports on the meeting, its structure, most relevant discussions and major conclusions.
2015-06-24T10:47:09Z
2015-06-24T10:47:09Z
2015-06
Article
Towards a framework for evaluating and grading evidence in public health. 2015, 119 (6):732-6 Health Policy
1872-6054
25863647
10.1016/j.healthpol.2015.02.010
http://hdl.handle.net/10033/558481
Health policy (Amsterdam, Netherlands)
en
oai:repository.helmholtz-hzi.de:10033/5604942019-08-30T11:28:23Zcom_10033_267632com_10033_211390col_10033_267633
An adjustable fetal weight standard for twins: a statistical modeling study.
Zhang, Jun
Mikolajczyk, Rafael
Lei, Xiaoping
Sun, Luming
Yu, Hongping
Cheng, Weiwei
Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors.
2015-07-15T14:24:02Z
2015-07-15T14:24:02Z
2015
Article
An adjustable fetal weight standard for twins: a statistical modeling study. 2015, 13:159 BMC Med
1741-7015
26141190
10.1186/s12916-015-0401-9
http://hdl.handle.net/10033/560494
BMC medicine
en
oai:repository.helmholtz-hzi.de:10033/5763072019-08-30T11:28:23Zcom_10033_267632com_10033_211390col_10033_267633
Mortality in the German Pharmacoepidemiological Research Database (GePaRD) compared to national data in Germany: results from a validation study.
Ohlmeier, Christoph
Langner, Ingo
Hillebrand, Kathrin
Schmedt, Niklas
Riedel, Oliver
Garbe, Edeltraut
Electronic healthcare databases are of increasing importance in health research and mortality is one of the most relevant outcomes. However, data in these databases need to be validated, since they are often generated for reimbursement purposes. The aims of this study were to compare mortality figures from the German Pharmacoepidemiological Research Database (GePaRD) on an aggregated level with external data from the Federal Statistical Office of Germany (FSOG) and to assess consistency of records of death from core data and hospital data within GePaRD.
2015-09-02T13:29:58Z
2015-09-02T13:29:58Z
2015
Article
Mortality in the German Pharmacoepidemiological Research Database (GePaRD) compared to national data in Germany: results from a validation study. 2015, 15:570 BMC Public Health
1471-2458
26087768
10.1186/s12889-015-1943-7
http://hdl.handle.net/10033/576307
BMC public health
en
oai:repository.helmholtz-hzi.de:10033/6211462019-08-30T11:31:23Zcom_10033_267632com_10033_211390col_10033_267633
A feasibility trial to examine the social norms approach for the prevention and reduction of licit and illicit drug use in European University and college students
Pischke, Claudia R
Zeeb, Hajo
van Hal, Guido
Vriesacker, Bart
McAlaney, John
Bewick, Bridgette M
Akvardar, Yildiz
Guillén-Grima, Francisco
Orosova, Olga
Salonna, Ferdinand
Kalina, Ondrej
Stock, Christiane
Helmer, Stefanie M
Mikolajczyk, Rafael T
Abstract Background Incorrect perceptions of high rates of peer alcohol and tobacco use are predictive of increased personal use in student populations. Correcting misperceptions by providing feedback has been shown to be an effective intervention for reducing licit drug use. It is currently unknown if social norms interventions are effective in preventing and reducing illicit drug use in European students. The purpose of this paper is to describe the design of a multi-site cluster controlled trial of a web-based social norms intervention aimed at reducing licit and preventing illicit drug use in European university students. Methods/Design An online questionnaire to assess rates of drug use will be developed and translated based on existing social norms surveys. Students from sixteen universities in seven participating European countries will be invited to complete the questionnaire. Both intervention and control sites will be chosen by convenience. In each country, the intervention site will be the university that the local principal investigator is affiliated with. We aim to recruit 1000 students per site (baseline assessment). All participants will complete the online questionnaire at baseline. Baseline data will be used to develop social norms messages that will be included in a web-based intervention. The intervention group will receive individualized social norms feedback. The website will remain online during the following 5 months. After five months, a second survey will be conducted and effects of the intervention on social norms and drug use will be measured in comparison to the control site. Discussion This project is the first cross-national European collaboration to investigate the feasibility of a social norms intervention to reduce licit and prevent illicit drug use among European university students. Final trial registration number DRKS00004375 on the ‘German Clinical Trials Register’.
2017-10-25T09:52:19Z
2017-10-25T09:52:19Z
2012-10-18
2015-09-04T08:22:17Z
Journal Article
BMC Public Health. 2012 Oct 18;12(1):882
http://dx.doi.org/10.1186/1471-2458-12-882
http://hdl.handle.net/10033/621146
en
Pischke et al.; licensee BioMed Central Ltd.
oai:repository.helmholtz-hzi.de:10033/6208442018-06-12T20:00:01Zcom_10033_211390col_10033_211409
Determinants of HIV, viral hepatitis and STI prevention needs among African migrants in Germany; a cross-sectional survey on knowledge, attitudes, behaviors and practices
Santos-Hövener, Claudia
Marcus, Ulrich
Koschollek, Carmen
Oudini, Hapsatou
Wiebe, Mara
Ouedraogo, Omer I
Thorlie, Adama
Bremer, Viviane
Hamouda, Osamah
Dierks, Marie-Luise
an der Heiden, Matthias
Krause, Gerard
Helmholtz Centre for infection research, Ihoffenstr. 7, 38124 Braunschweig, Germany.
Abstract Background Migrants from sub-Saharan Africa (MisSA) are a relevant sub-group for HIV-transmission in Germany. A total of 10-15 % of all newly diagnosed cases are MisSA, and approximately one third acquired HIV in Germany. There is limited information on knowledge, attitudes, behaviors and practices (KABP) regarding sexual health in African communities residing in Germany. Methods From October-December 2013 we conducted a cross-sectional survey on KABP regarding HIV, viral hepatitis (HEP), and sexually transmitted infections (STI) among MisSA in Hamburg as a community-based participatory research project to identify knowledge gaps, sexual risk behavior regarding HIV/HEP/STI, HIV/STI-testing history and attitudes toward people living with HIV (PLWH). Trained peer researchers recruited participants through outreach. Questionnaires in German, English or French were either administered face-to-face or self-completed. Questions on knowledge about HIV/HEP/STI presented true statements; participants were asked if they knew the information before. To detect differences in sub-groups, unadjusted odds ratios (OR) were calculated, and a multivariate analysis for knowledge on HIV/HEP/STI was performed. Results The final sample included 569 participants of whom 57 % were men. Most participants originated from Western and Central sub-Saharan Africa. Median time living in Germany was 6 years. Overall, 28 % had a university degree and 54 % reported a good level of German language. Over 80 % knew the risks for HIV transmission. A total of 44 % of respondents wrongly assumed that an HIV-diagnosis might lead to deportation and 64 % were not aware of the free and anonymous local HIV/STI-testing service. The proportion of participants with knowledge of presented facts on HEP varied from 40-58 %. The respective proportion on STI was 28-68 % and better among women compared to men (44 % vs. 54 %; OR = 1.45; 95 % CI 1.22-1.74). Men reported more often casual sex partners than women (43 % vs. 23 %; OR = 2.6; 95 % CI 1.7-4.0), and more frequently a previous STI (58 % vs. 39 %; OR = 2.1; 95 % CI 1.1-4.1). Overall, 16 % of women reported a history of sexual violence. The majority of respondents (75 %) reported that they would treat PLWH like any other person. Conclusion Study participants demonstrated good knowledge on HIV-transmission but knowledge gaps regarding HIV/STI-testing services, HEP and STI. This calls for targeted interventions providing more information about these topics in African communities in Hamburg and possibly also elsewhere.
2017-03-06T11:38:59Z
2017-03-06T11:38:59Z
2015-08-06
2015-09-04T08:26:28Z
Article
BMC Public Health. 2015 Aug 06;15(1):753
http://dx.doi.org/10.1186/s12889-015-2098-2
http://hdl.handle.net/10033/620844
en
Santos-Hövener et al.
oai:repository.helmholtz-hzi.de:10033/6207892019-08-30T11:37:44Zcom_10033_267632com_10033_211390col_10033_267633
Health-related locus of control and health behaviour among university students in North Rhine Westphalia, Germany
Helmer, Stefanie M
Krämer, Alexander
Mikolajczyk, Rafael
Abstract Background Health control beliefs were postulated to be associated with health behaviour. However, the results of studies assessing these associations suggest that they might not be universal. Among young adults associations have been reported, but the evidence is limited. The objective of this analysis was to re-examine these associations in a sample of university students in Germany. Findings Data from a multicentre cross-sectional study among university students in North Rhine-Westphalia, Germany was used (N=3,306). The Multidimensional Health Locus of Control Scale with three dimensions (one internal and two external) and six aspects of health behaviour (smoking habits, alcohol use, drug consumption, being over-/ or underweight, physical activity, and importance of healthy nutrition) were evaluated. Students with stronger internal locus of control paid more attention to healthy nutrition and displayed a higher level of physical activity. Individuals with a stronger belief in health professionals were less likely to use drugs and paid more attention to healthy nutrition. Furthermore, higher scores in the second external locus of control dimension (beliefs in luck or chance) were associated with a higher likelihood of current smoking, lower physical activity and less attention to healthy nutrition. Conclusions Students engaged more strongly in unhealthy behaviour if they believed that luck determines health. In contrast, believing in having control over one’s own health was associated with more healthy behaviour. These findings support the need to consider health control beliefs while designing preventive strategies in this specific population.
2017-01-27T11:51:23Z
2017-01-27T11:51:23Z
2012-12-29
2015-09-04T08:25:55Z
BMC Research Notes. 2012 Dec 29;5(1):703
http://dx.doi.org/10.1186/1756-0500-5-703
http://hdl.handle.net/10033/620789
en
Helmer et al.; licensee BioMed Central Ltd.
oai:repository.helmholtz-hzi.de:10033/6207532018-06-13T07:23:02Zcom_10033_267632com_10033_211390col_10033_267633
Mortality in the German Pharmacoepidemiological Research Database (GePaRD) compared to national data in Germany: results from a validation study
Ohlmeier, Christoph
Langner, Ingo
Hillebrand, Kathrin
Schmedt, Niklas
Mikolajczyk, Rafael
Riedel, Oliver
Garbe, Edeltraut
Abstract Background Electronic healthcare databases are of increasing importance in health research and mortality is one of the most relevant outcomes. However, data in these databases need to be validated, since they are often generated for reimbursement purposes. The aims of this study were to compare mortality figures from the German Pharmacoepidemiological Research Database (GePaRD) on an aggregated level with external data from the Federal Statistical Office of Germany (FSOG) and to assess consistency of records of death from core data and hospital data within GePaRD. Methods The study population comprised insurants of four statutory health insurances providing data for GePaRD with either continuous insurance coverage from January 1st to December 31st 2006 or until death. The sex-specific mortality rate, stratified and standardized by age, and the percentage of hospital deaths among all deaths was compared with data from the FSOG. Furthermore, the agreement between the dates of death according to hospital data and core data was assessed within GePaRD. Results The study population comprised 12,033,622 insurants. Compared to FSOG data, the age-standardised mortality rate in GePaRD was 21 % and 29 % lower in women and men, respectively. Regional analyses also indicated lower mortality rates in all federal states except for Bremen, where the age-standardised mortality rate was similar to FSOG data for both sexes. The percentage of hospital deaths among all deaths corresponded well with external data. The proportion of inpatient deaths also recorded in the health insurance core data was 98.5 %. Furthermore, 94 % of dates of death documented in hospital agreed with the dates of death according to the health insurance core data. Conclusions The lower mortality rates in almost all federal states might result from the higher socioeconomic status of the GePaRD study population compared to the overall population in Germany. In the federal state of Bremen, where socioeconomic representativeness is higher due to additional inclusion of two local health insurances, the mortality rates were in good accordance with external data. Agreement of the percentage of hospital deaths among all deaths between GePaRD and national statistics suggested completeness of outpatient mortality information.
2017-01-27T08:28:09Z
2017-01-27T08:28:09Z
2015-06-20
2015-09-04T08:29:23Z
Journal Article
BMC Public Health. 2015 Jun 20;15(1):570
http://dx.doi.org/10.1186/s12889-015-1943-7
http://hdl.handle.net/10033/620753
en
Ohlmeier et al.
oai:repository.helmholtz-hzi.de:10033/6207192019-08-30T11:36:05Zcom_10033_267632com_10033_211390col_10033_267633
What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies
Betran, Ana P
Torloni, Maria R
Zhang, Jun
Ye, Jiangfeng
Mikolajczyk, Rafael
Deneux-Tharaux, Catherine
Oladapo, Olufemi T
Souza, João P
Tunçalp, Özge
Vogel, Joshua P
Gülmezoglu, Ahmet M
Abstract In 1985, WHO stated that there was no justification for caesarean section (CS) rates higher than 10–15 % at population-level. While the CS rates worldwide have continued to increase in an unprecedented manner over the subsequent three decades, concern has been raised about the validity of the 1985 landmark statement. We conducted a systematic review to identify, critically appraise and synthesize the analyses of the ecologic association between CS rates and maternal, neonatal and infant outcomes. Four electronic databases were searched for ecologic studies published between 2000 and 2014 that analysed the possible association between CS rates and maternal, neonatal or infant mortality or morbidity. Two reviewers performed study selection, data extraction and quality assessment independently. We identified 11,832 unique citations and eight studies were included in the review. Seven studies correlated CS rates with maternal mortality, five with neonatal mortality, four with infant mortality, two with LBW and one with stillbirths. Except for one, all studies were cross-sectional in design and five were global analyses of national-level CS rates versus mortality outcomes. Although the overall quality of the studies was acceptable; only two studies controlled for socio-economic factors and none controlled for clinical or demographic characteristics of the population. In unadjusted analyses, authors found a strong inverse relationship between CS rates and the mortality outcomes so that maternal, neonatal and infant mortality decrease as CS rates increase up to a certain threshold. In the eight studies included in this review, this threshold was at CS rates between 9 and 16 %. However, in the two studies that adjusted for socio-economic factors, this relationship was either weakened or disappeared after controlling for these confounders. CS rates above the threshold of 9–16 % were not associated with decreases in mortality outcomes regardless of adjustments. Our findings could be interpreted to mean that at CS rates below this threshold, socio-economic development may be driving the ecologic association between CS rates and mortality. On the other hand, at rates higher than this threshold, there is no association between CS and mortality outcomes regardless of adjustment. The ecological association between CS rates and relevant morbidity outcomes needs to be evaluated before drawing more definite conclusions at population level.
2017-01-17T10:01:28Z
2017-01-17T10:01:28Z
2015-06-21
2015-09-04T08:29:09Z
Journal Article
Reproductive Health. 2015 Jun 21;12(1):57
http://dx.doi.org/10.1186/s12978-015-0043-6
http://hdl.handle.net/10033/620719
en
Betran et al.
oai:repository.helmholtz-hzi.de:10033/6207002019-08-30T11:32:16Zcom_10033_267632com_10033_211390col_10033_267633
An adjustable fetal weight standard for twins: a statistical modeling study
Zhang, Jun
Mikolajczyk, Rafael
Lei, Xiaoping
Sun, Luming
Yu, Hongping
Cheng, Weiwei
Abstract Background It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors. Methods Over half a million twin births of low risk pregnancies in the US, from 1995 to 2004, were used to construct a fetal weight standard. We used the Hadlock’s fetal growth standard and the proportionality principle to make the standard adjustable for other factors such as race/ethnicity. We validated the standard in different race/ethnicities in the US and against previously published curves from around the world. Results The adjustable fetal weight standard has an excellent match with the observed birthweight data in non-Hispanic White, non-Hispanic Black, Hispanics, and Asian from 24 to 38 weeks gestation. It also had a very good fit with cross-sectional data from Australia and Norway, and a longitudinal standard from Brazil. However, our model-based 10th and 90th percentiles differed substantially from studies in Japan and US that used the last menstrual period for estimate of gestational age. Conclusion The adjustable fetal weight standard for twins is a flexible tool and can be used in different populations.
2017-01-13T09:52:44Z
2017-01-13T09:52:44Z
2015-07-03
2015-09-04T08:31:04Z
Journal Article
BMC Medicine. 2015 Jul 03;13(1):159
http://dx.doi.org/10.1186/s12916-015-0401-9
http://hdl.handle.net/10033/620700
en
Zhang et al.
oai:repository.helmholtz-hzi.de:10033/6206952019-08-30T11:31:49Zcom_10033_211390col_10033_211409
Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools
Harder, Thomas
Takla, Anja
Rehfuess, Eva
Sánchez-Vivar, Alex
Matysiak-Klose, Dorothea
Eckmanns, Tim
Krause, Gérard
de Carvalho Gomes, Helena
Jansen, Andreas
Ellis, Simon
Forland, Frode
James, Roberta
Meerpohl, Joerg J
Morgan, Antony
Schünemann, Holger
Zuiderent-Jerak, Teun
Wichmann, Ole
Abstract Background The Project on a Framework for Rating Evidence in Public Health (PRECEPT) was initiated and is being funded by the European Centre for Disease Prevention and Control (ECDC) to define a methodology for evaluating and grading evidence and strength of recommendations in the field of public health, with emphasis on infectious disease epidemiology, prevention and control. One of the first steps was to review existing quality appraisal tools (QATs) for individual research studies of various designs relevant to this area, using a question-based approach. Methods Through team discussions and expert consultations, we identified 20 relevant types of public health questions, which were grouped into six domains, i.e. characteristics of the pathogen, burden of disease, diagnosis, risk factors, intervention, and implementation of intervention. Previously published systematic reviews were used and supplemented by expert consultation to identify suitable QATs. Finally, a matrix was constructed for matching questions to study designs suitable to address them and respective QATs. Key features of each of the included QATs were then analyzed, in particular in respect to its intended use, types of questions and answers, presence/absence of a quality score, and if a validation was performed. Results In total we identified 21 QATs and 26 study designs, and matched them. Four QATs were suitable for experimental quantitative study designs, eleven for observational quantitative studies, two for qualitative studies, three for economic studies, one for diagnostic test accuracy studies, and one for animal studies. Included QATs consisted of six to 28 items. Six of the QATs had a summary quality score. Fourteen QATs had undergone at least one validation procedure. Conclusions The results of this methodological study can be used as an inventory of potentially relevant questions, appropriate study designs and QATs for researchers and authorities engaged with evidence-based decision-making in infectious disease epidemiology, prevention and control.
2017-01-13T09:49:01Z
2017-01-13T09:49:01Z
2014-05-21
2015-09-04T08:31:18Z
Journal Article
BMC Medical Research Methodology. 2014 May 21;14(1):69
http://dx.doi.org/10.1186/1471-2288-14-69
http://hdl.handle.net/10033/620695
en
Harder et al.; licensee BioMed Central Ltd.
oai:repository.helmholtz-hzi.de:10033/5769412019-08-30T11:28:23Zcom_10033_211390col_10033_211409
The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort.
Schweitzer, Aparna
Akmatov, Manas K
Kindler, Florentina
Kemmling, Yvonne
Kreienbrock, Lothar
Krause, Gerard
Pessler, Frank
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany
In this pilot study within the Pretest 2 phase of the German National Cohort, we aimed to (1) test the hypothesis that distance and duration of travel to a study centre may affect participation rates and participants' satisfaction and (2) to obtain data that would help to select recruitment areas around the study centre Hannover with the greatest projected participation rate for the main study.
2015-09-08T13:39:24Z
2015-09-08T13:39:24Z
2015
Article
The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort. 2015, 5 (8):e007461 BMJ Open
2044-6055
26297358
10.1136/bmjopen-2014-007461
http://hdl.handle.net/10033/576941
BMJ open
en
oai:repository.helmholtz-hzi.de:10033/5772422019-08-30T11:34:48Zcom_10033_267632com_10033_211390col_10033_267633
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease.
Karch, André
Hermann, Peter
Ponto, Claudia
Schmitz, Matthias
Arora, Amandeep
Zafar, Saima
Llorens, Franc
Müller-Heine, Annika
Zerr, Inga
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic marker for patient survival. However, subtype determination is not possible during lifetime. Because the rate of disease progression is associated with the molecular subtype, this study aimed at investigating if total tau, a marker of neuronal death, allows premortem diagnosis of molecular subtype when codon 129 genotype is known. Two hundred ninety-six sCJD patients were tested for their cerebrospinal fluid total tau level at the time of diagnosis and were investigated for their sCJD subtype postmortem. There was a significant association between tau levels and the prion protein type in patients with codon 129 MM (p < 0.001), MV (p = 0.004), and VV (p = 0.001) genotype. Receiver operating characteristic analyses showed values of area under the curve of 0.76-0.80 for the different genotypes indicating a good diagnostic validity of the test. Total tau can be used as a diagnostic test for the assessment of prion protein type when codon 129 genotype is known. It provides valuable information for physicians and next of kin about the further course of disease.
2015-09-14T13:58:08Z
2015-09-14T13:58:08Z
2015-05
Article
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease. 2015, 36 (5):1964-8 Neurobiol. Aging
1558-1497
25749129
10.1016/j.neurobiolaging.2015.01.021
http://hdl.handle.net/10033/577242
Neurobiology of aging
en
oai:repository.helmholtz-hzi.de:10033/5794712019-08-30T11:30:58Zcom_10033_267632com_10033_211390col_10033_267633
Clustering of developmental delays in Bavarian preschool children - a repeated cross-sectional survey over a period of 12 years.
Stich, Heribert L
Krämer, Alexander
Mikolajczyk, Rafael
Child, Preschool
Cluster Analysis
Cross-Sectional Studies
Developmental Disabilities
Female
Germany
Humans
Male
Time Factors
While most children display a normal development, some children experience developmental delays compared to age specific development milestones assessed during school entry examination. Data exist on prevalence of delays in single areas, but there is lack of knowledge regarding the clustering patterns of developmental delays and their determinants.
2015-10-08T10:00:10Z
2015-10-08T10:00:10Z
2014
Article
Clustering of developmental delays in Bavarian preschool children - a repeated cross-sectional survey over a period of 12 years. 2014, 14:18 BMC Pediatr
1471-2431
24450504
10.1186/1471-2431-14-18
http://hdl.handle.net/10033/579471
BMC pediatrics
en
oai:repository.helmholtz-hzi.de:10033/5801102019-08-30T11:31:23Zcom_10033_211390col_10033_211409
Determinants of HIV, viral hepatitis and STI prevention needs among African migrants in Germany; a cross-sectional survey on knowledge, attitudes, behaviors and practices.
Santos-Hövener, Claudia
Marcus, Ulrich
Koschollek, Carmen
Oudini, Hapsatou
Wiebe, Mara
Ouedraogo, Omer Idrissa
Thorlie, Adama
Bremer, Viviane
Hamouda, Osamah
Dierks, Marie-Luise
An der Heiden, Matthias
Krause, Gerard
Migrants from sub-Saharan Africa (MisSA) are a relevant sub-group for HIV-transmission in Germany. A total of 10-15 % of all newly diagnosed cases are MisSA, and approximately one third acquired HIV in Germany. There is limited information on knowledge, attitudes, behaviors and practices (KABP) regarding sexual health in African communities residing in Germany.
2015-10-22T08:27:02Z
2015-10-22T08:27:02Z
2015
Article
Determinants of HIV, viral hepatitis and STI prevention needs among African migrants in Germany; a cross-sectional survey on knowledge, attitudes, behaviors and practices. 2015, 15:753 BMC Public Health
1471-2458
26246382
10.1186/s12889-015-2098-2
http://hdl.handle.net/10033/580110
BMC public health
en
oai:repository.helmholtz-hzi.de:10033/5800102019-08-30T11:31:22Zcom_10033_211390col_10033_211409
Regulatory principles governing Salmonella and Yersinia virulence.
Erhardt, Marc
Dersch, Petra
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Enteric pathogens such as Salmonella and Yersinia evolved numerous strategies to survive and proliferate in different environmental reservoirs and mammalian hosts. Deciphering common and pathogen-specific principles for how these bacteria adjust and coordinate spatiotemporal expression of virulence determinants, stress adaptation, and metabolic functions is fundamental to understand microbial pathogenesis. In order to manage sudden environmental changes, attacks by the host immune systems and microbial competition, the pathogens employ a plethora of transcriptional and post-transcriptional control elements, including transcription factors, sensory and regulatory RNAs, RNAses, and proteases, to fine-tune and control complex gene regulatory networks. Many of the contributing global regulators and the molecular mechanisms of regulation are frequently conserved between Yersinia and Salmonella. However, the interplay, arrangement, and composition of the control elements vary between these closely related enteric pathogens, which generate phenotypic differences leading to distinct pathogenic properties. In this overview we present common and different regulatory networks used by Salmonella and Yersinia to coordinate the expression of crucial motility, cell adhesion and invasion determinants, immune defense strategies, and metabolic adaptation processes. We highlight evolutionary changes of the gene regulatory circuits that result in different properties of the regulatory elements and how this influences the overall outcome of the infection process.
2015-10-21T13:23:33Z
2015-10-21T13:23:33Z
2015
Article
Regulatory principles governing Salmonella and Yersinia virulence. 2015, 6:949 Front Microbiol
1664-302X
26441883
10.3389/fmicb.2015.00949
http://hdl.handle.net/10033/580010
Frontiers in microbiology
en
info:eu-repo/grantAgreement/EC/FP7/334030
openAccess
oai:repository.helmholtz-hzi.de:10033/5801112019-08-30T11:35:14Zcom_10033_211390com_10033_620601col_10033_211409col_10033_620603
Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan.
Schweitzer, A
Krause, Gerard
Pessler, F
Akmatov, M K
Timing of childhood vaccinations has received close attention in many countries. Little is known about the trends in correctly timed vaccination in former Soviet countries. We examined trends in vaccination coverage and correct timing of vaccination in two post-Soviet countries, Armenia and Kyrgyzstan, and analyzed factors associated with delayed vaccinations.
2015-10-22T08:39:41Z
2015-10-22T08:39:41Z
2015
Article
Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan. 2015, 15 (1):798 BMC Public Health
1471-2458
26285702
10.1186/s12889-015-2091-9
http://hdl.handle.net/10033/580111
BMC public health
en
oai:repository.helmholtz-hzi.de:10033/5814552019-08-30T11:33:57Zcom_10033_211390col_10033_211409
Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany.
Akmatov, Manas K
Mehraj, Jaishri
Gatzemeier, Anja
Strömpl, Julia
Witte, Wolfgang
Krause, Gerard
Pessler, Frank
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Adult
Carrier State
Female
Germany
Humans
Male
Middle Aged
Nasal Mucosa
Patient Compliance
Population Surveillance
Prospective Studies
Questionnaires
Risk Factors
Staphylococcal Infections
Staphylococcus aureus
Participant-collected serial nasal swabs would be a cost-efficient feature of prospective population-based microbiological studies. We examined the feasibility of serial anterior nasal self-swabbing for Staphylococcus aureus detection in a prospective population-based study in Braunschweig, Germany, and assessed the impact of three interventions on participation and compliance.
2015-10-30T15:05:47Z
2015-10-30T15:05:47Z
2014-08
Article
Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany. 2014, 25:4-10 Int. J. Infect. Dis.
1878-3511
24813875
10.1016/j.ijid.2014.01.021
http://hdl.handle.net/10033/581455
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
en
oai:repository.helmholtz-hzi.de:10033/5815912019-08-30T11:31:49Zcom_10033_211390col_10033_211409
A survey of outpatient antibiotic prescribing for cystitis.
Velasco, Edward
Noll, Ines
Espelage, Werner
Ziegelmann, Antina
Krause, Gerard
Eckmanns, Tim
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Ambulatory Care
Anti-Bacterial Agents
Cystitis
Germany
Guideline Adherence
Health Care Surveys
Humans
Inappropriate Prescribing
Prescriptions
Prevalence
Risk Assessment
Risk Factors
In view of the currently increasing rates of antibiotic resistance, we studied the factors that affect the prescribing of specific antibiotics for uncomplicated cystitis in outpatient care.
2015-11-03T09:56:12Z
2015-11-03T09:56:12Z
2012-12
Article
A survey of outpatient antibiotic prescribing for cystitis. 2012, 109 (50):878-84 Dtsch Arztebl Int
1866-0452
23293677
10.3238/arztebl.2012.0878
http://hdl.handle.net/10033/581591
Deutsches Ärzteblatt international
en
oai:repository.helmholtz-hzi.de:10033/5818992019-08-30T11:31:49Zcom_10033_211390col_10033_211409
[Epidemiology and clinical symptomatology of Creutzfeldt-Jakob disease].
Mollenhauer, B
Zerr, I
Ruge, D
Krause, Gerard
Mehnert, W H
Kretzschmar, H A
Poser, S
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Adult
Aged
Aged, 80 and over
Autopsy
Creutzfeldt-Jakob Syndrome
Diagnosis, Differential
Female
Germany
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk Factors
Analogous to prospective studies in other countries, prevalance and symptoms of sporadic Creutzfeldt-Jakob disease (CJD) were recorded in order to assess irregularities in the incidence of the disease in Germany since the onset of bovine spongioform encephalopathy (BSE).
2015-11-06T14:17:38Z
2015-11-06T14:17:38Z
2002-02-15
Article
[Epidemiology and clinical symptomatology of Creutzfeldt-Jakob disease]. 2002, 127 (7):312-7 Dtsch. Med. Wochenschr.
0012-0472
11845386
10.1055/s-2002-20150
http://hdl.handle.net/10033/581899
Deutsche medizinische Wochenschrift (1946)
ger
oai:repository.helmholtz-hzi.de:10033/5827822019-08-30T11:33:05Zcom_10033_211390col_10033_211409
Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study.
Sievers, Claudia
Akmatov, Manas K
Kreienbrock, Lothar
Hille, Katja
Ahrens, Wolfgang
Günther, Kathrin
Flesch-Janys, Dieter
Obi, Nadia
Michels, Karin B
Fricke, Julia
Greiser, Karin H
Kaaks, Rudolf
Peter, Hans-Hartmut
Pessler, Frank
Nieters, Alexandra
Krause, Gerard
Adult
Aged
Cohort Studies
Communicable Diseases
Feasibility Studies
Germany
Humans
Immunocompromised Host
Male
Middle Aged
Population Surveillance
Prevalence
Questionnaires
Reproducibility of Results
Risk Assessment
Sensitivity and Specificity
Young Adult
The risk to die from an infectious disease in Germany has been continuously decreasing over the last century. Since infections are, however, not only causes of death but risk factors for diseases like cardiovascular diseases, it is essential to monitor and analyze their prevalence and frequency, especially in consideration of the increased life expectancy. To gain more knowledge about infectious diseases as risk factors and their implications on the condition and change of the immune status, the German National Cohort (GNC), a population-based prospective cohort study, will recruit 200,000 subjects between 2014 and 2017. In Pretest 1, a feasibility study for the GNC, we evaluated a self-administered and self-report questionnaire on infectious diseases and on the use of health care facilities (hereinafter called "ID Screen") for feasibility and validity.
2015-11-27T10:47:24Z
2015-11-27T10:47:24Z
2014-11
Article
Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study. 2014, 57 (11):1283-91 Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
1437-1588
25300826
10.1007/s00103-014-2052-y
http://hdl.handle.net/10033/582782
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
en
oai:repository.helmholtz-hzi.de:10033/5819952019-08-30T11:33:03Zcom_10033_211390col_10033_211409
Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011.
Askar, M
Faber, M S
Frank, C
Bernard, H
Gilsdorf, A
Fruth, A
Prager, R
Hohle, M
Suess, T
Wadl, M
Krause, Gerard
Stark, K
Werber, D
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Disease Notification
Disease Outbreaks
Escherichia coli Infections
Female
Food Contamination
Food Microbiology
Germany
Hemolytic-Uremic Syndrome
Humans
Incidence
Infant
Male
Middle Aged
Serotyping
Shiga Toxin
Shiga-Toxigenic Escherichia coli
Travel
Vegetables
Young Adult
2015-11-10T15:07:32Z
2015-11-10T15:07:32Z
2011
Article
Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011. 2011, 16 (22): Euro Surveill.
1560-7917
21663710
http://hdl.handle.net/10033/581995
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
en
oai:repository.helmholtz-hzi.de:10033/5820652019-08-30T11:31:49Zcom_10033_267632com_10033_211390col_10033_267633
Ebola risk perception in Germany, 2014.
Rübsamen, Nicole
Castell, Stefanie
Horn, Johannes
Karch, André
Ott, Jördis J
Raupach-Rosin, Heike
Zoch, Beate
Krause, Gerard
Mikolajczyk, Rafael T
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Ebola virus disease (EVD) outbreaks have occurred during the past 5 decades, but none has affected European countries like the 2014 epidemic in West Africa. We used an online questionnaire to investigate risk perceptions in Germany during this epidemic peak. Our questionnaire covered risk perceptions, knowledge about transmission routes, media use, reactions to the outbreak, attitudes toward measures to prevent the spread of EVD and vaccination against EVD, and willingness to volunteer for aid missions. Of 974 participants, 29% indicated that they worried about EVD, 4% correctly stated virus transmission routes, and 75% incorrectly rated airborne transmission and transmission by asymptomatic patients as possible. Many indicated that if a patient were flown to Germany for treatment in a nearby hospital, they would adapt preventive behavior. Although most participants were not worried about EVD at the current stage of the epidemic, misperceptions regarding transmission were common and could trigger inappropriate behavior changes.
2015-11-11T14:34:16Z
2015-11-11T14:34:16Z
2015-06
Article
Ebola risk perception in Germany, 2014. 2015, 21 (6):1012-8 Emerging Infect. Dis.
1080-6059
25989020
10.3201/eid2106.150013
http://hdl.handle.net/10033/582065
Emerging infectious diseases
en
oai:repository.helmholtz-hzi.de:10033/5822222019-08-30T11:33:57Zcom_10033_211390col_10033_211409
Eliciting views on antibiotic prescribing and resistance among hospital and outpatient care physicians in Berlin, Germany: results of a qualitative study.
Velasco, Edward
Ziegelmann, Antina
Eckmanns, Tim
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
To better understand physicians' views on factors of influence for the prescribing of antibiotics and on antibiotic resistance in the Berlin region, Germany.
2015-11-16T14:03:49Z
2015-11-16T14:03:49Z
2012
Article
Eliciting views on antibiotic prescribing and resistance among hospital and outpatient care physicians in Berlin, Germany: results of a qualitative study. 2012, 2 (1):e000398 BMJ Open
2044-6055
22307097
10.1136/bmjopen-2011-000398
http://hdl.handle.net/10033/582222
BMJ open
en
oai:repository.helmholtz-hzi.de:10033/5822802019-08-30T11:34:22Zcom_10033_211390col_10033_211409
Herpes zoster in Germany: quantifying the burden of disease.
Ultsch, Bernhard
Siedler, Anette
Rieck, Thorsten
Reinhold, Thomas
Krause, Gerard
Wichmann, Ole
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Aged
Aged, 80 and over
Cost of Illness
Cost-Benefit Analysis
Female
Germany
Herpes Zoster
Herpes Zoster Vaccine
Hospitalization
Humans
Incidence
Male
Middle Aged
Outpatients
Poisson Distribution
Herpes zoster (HZ) is caused by a reactivation of the varicella-zoster-virus (VZV) and mainly affects individuals aged≥50 years. Vaccines have been licensed or are under development that can protect against HZ and its main complication postherpetic neuralgia (PHN). In Germany, the burden of disease caused by HZ is not well known. To support the decision making process related to a potential vaccination recommendation, we estimated annual HZ disease burden in people aged≥50 years in Germany by utilizing various data sources.
2015-11-17T09:49:47Z
2015-11-17T09:49:47Z
2011
Article
Herpes zoster in Germany: quantifying the burden of disease. 2011, 11:173 BMC Infect. Dis.
1471-2334
21679419
10.1186/1471-2334-11-173
http://hdl.handle.net/10033/582280
BMC infectious diseases
en
oai:repository.helmholtz-hzi.de:10033/5823332019-08-30T11:34:48Zcom_10033_267632com_10033_211390col_10033_267633
Feasibility of a birth cohort study dedicated to assessing acute infections using symptom diaries and parental collection of biomaterials.
Zoch, Beate
Karch, André
Dreesman, Johannes
Monazahian, Masyar
Baillot, Armin
Mikolajczyk, Rafael
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
A birth cohort dedicated to studying infections in early childhood may be assisted by parental recording of symptoms on a daily basis and a collection of biomaterials. We aimed at testing the feasibility of this approach for use in a long-term study focusing on infections in children in Germany.
2015-11-18T09:13:25Z
2015-11-18T09:13:25Z
2015
Article
Feasibility of a birth cohort study dedicated to assessing acute infections using symptom diaries and parental collection of biomaterials. 2015, 15:436 BMC Infect. Dis.
1471-2334
26493700
10.1186/s12879-015-1189-0
http://hdl.handle.net/10033/582333
BMC infectious diseases
en
oai:repository.helmholtz-hzi.de:10033/5826832019-08-30T11:35:39Zcom_10033_211390col_10033_211409
High level of gastrointestinal nosocomial infections in the german surveillance system, 2002-2008.
Spackova, Michaela
Altmann, Doris
Eckmanns, Tim
Koch, Judith
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Adolescent
Adult
Age Distribution
Aged
Campylobacter
Campylobacter Infections
Child
Child, Preschool
Cross Infection
Female
Gastroenteritis
Geography
Germany
Hospitals
Humans
Infant
Infant, Newborn
Male
Middle Aged
Multivariate Analysis
Norovirus
Risk Factors
Rotavirus
Rotavirus Infections
Salmonella
Salmonella Infections
Sentinel Surveillance
Young Adult
Surveillance of nosocomial infections (NIs) is well established in many countries but often does not include gastrointestinal infections. We sought to determine the proportion of NIs among all hospitalized cases for the 4 most prevalent types of gastrointestinal infections in Germany.
2015-11-25T12:57:19Z
2015-11-25T12:57:19Z
2010-12
Article
High level of gastrointestinal nosocomial infections in the german surveillance system, 2002-2008. 2010, 31 (12):1273-8 Infect Control Hosp Epidemiol
1559-6834
21047180
10.1086/657133
http://hdl.handle.net/10033/582683
Infection control and hospital epidemiology
en
oai:repository.helmholtz-hzi.de:10033/5827282019-08-30T11:35:39Zcom_10033_211390col_10033_211409
Development of a risk assessment tool for contact tracing people after contact with infectious patients while travelling by bus or other public ground transport: a Delphi consensus approach.
Mohr, Oliver
Hermes, Julia
Schink, Susanne B
Askar, Mona
Menucci, Daniel
Swaan, Corien
Goetsch, Udo
Monk, Philip
Eckmanns, Tim
Poggensee, Gabriele
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Tracing persons who have been in contact with an infectious patient may be very effective in preventing the spread of communicable diseases. However, criteria to decide when to conduct contact tracing are not well established. We have investigated the available evidence for contact tracing with a focus on public ground transport aiming to give guidance in what situations contact tracing should be considered.
2015-11-25T15:17:54Z
2015-11-25T15:17:54Z
2013
Article
Development of a risk assessment tool for contact tracing people after contact with infectious patients while travelling by bus or other public ground transport: a Delphi consensus approach. 2013, 3 (10):e002939 BMJ Open
2044-6055
24157815
10.1136/bmjopen-2013-002939
http://hdl.handle.net/10033/582728
BMJ open
en
oai:repository.helmholtz-hzi.de:10033/5827362019-08-30T11:35:39Zcom_10033_211390col_10033_211409
Health economic evaluation of vaccination strategies for the prevention of herpes zoster and postherpetic neuralgia in Germany.
Ultsch, Bernhard
Weidemann, Felix
Reinhold, Thomas
Siedler, Anette
Krause, Gerard
Wichmann, Ole
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Aged
Aged, 80 and over
Cost-Benefit Analysis
Female
Germany
Health Care Costs
Herpes Zoster
Herpes Zoster Vaccine
Humans
Male
Markov Chains
Middle Aged
Models, Economic
Neuralgia, Postherpetic
Quality-Adjusted Life Years
Herpes zoster (HZ) is a self-limiting painful skin rash affecting mostly individuals from 50 years of age. The main complication is postherpetic neuralgia (PHN), a long-lasting pain after rash has resolved. A HZ-vaccine has recently been licensed in Europe for individuals older than 50 years. To support an informed decision-making for a potential vaccination recommendation, we conducted a health economic evaluation to identify the most cost-effective vaccination strategy.
2015-11-25T15:53:39Z
2015-11-25T15:53:39Z
2013
Article
Health economic evaluation of vaccination strategies for the prevention of herpes zoster and postherpetic neuralgia in Germany. 2013, 13:359 BMC Health Serv Res
1472-6963
24070414
10.1186/1472-6963-13-359
http://hdl.handle.net/10033/582736
BMC health services research
en
oai:repository.helmholtz-hzi.de:10033/5829722019-08-30T11:32:16Zcom_10033_211390col_10033_211409
Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009-2010.
Heideking, M
Lander, F
Hufnagel, M
Pfeifer, Y
Wicker, E
Krause, Gerard
Berner, R
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Anti-Bacterial Agents
Drug Resistance, Bacterial
Epidemiological Monitoring
Escherichia coli
Escherichia coli Infections
Germany
Humans
Infant, Newborn
Microbial Sensitivity Tests
A nationwide 2-year surveillance study on invasive neonatal Escherichia coli infections in Germany was conducted. A total of 158 isolates were tested for antibiotic susceptibility. The empirical treatment regimen of ampicillin plus gentamicin for neonatal sepsis appears to remain effective, but emerging resistance needs to be closely monitored.
2015-11-30T15:34:58Z
2015-11-30T15:34:58Z
2013-09
Article
Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009-2010. 2013, 32 (9):1221-3 Eur. J. Clin. Microbiol. Infect. Dis.
1435-4373
23558366
10.1007/s10096-013-1871-3
http://hdl.handle.net/10033/582972
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
en
oai:repository.helmholtz-hzi.de:10033/5928272019-08-30T11:36:04Zcom_10033_267632com_10033_211390col_10033_267633
Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data.
Ye, J
Zhang, J
Mikolajczyk, Rafael
Torloni, M R
Gülmezoglu, A M
Betran, A P
Helmholtz Centre for Infectoion Research; Inhoffenstr.7 38124 Braunschweig; Germany.
Caesarean section was initially performed to save the lives of the mother and/or her baby. Caesarean section rates have risen substantially worldwide over the past decades. In this study, we set out to compile all available caesarean section rates worldwide at the country level, and to identify the appropriate caesarean section rate at the population level associated with the minimal maternal and neonatal mortality.
2016-01-05T12:14:51Z
2016-01-05T12:14:51Z
2015-08-24
Article
Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. 2015: BJOG
1471-0528
26331389
10.1111/1471-0528.13592
http://hdl.handle.net/10033/592827
BJOG : an international journal of obstetrics and gynaecology
ENG
oai:repository.helmholtz-hzi.de:10033/5931002019-08-30T11:36:32Zcom_10033_267632com_10033_211390col_10033_267633
Individual development of preschool children-prevalences and determinants of delays in Germany: a cross-sectional study in Southern Bavaria.
Stich, Heribert L
Baune, Bernhard Th
Caniato, Riccardo N
Mikolajczyk, Rafael
Krämer, Alexander
Age Factors
Child
Child, Preschool
Cross-Sectional Studies
Developmental Disabilities
Emigrants and Immigrants
Female
Germany
Humans
Logistic Models
Male
Multivariate Analysis
Prevalence
Psychological Tests
Risk Factors
Sex Factors
Even minor abnormalities of early child development may have dramatic long term consequences. Accurate prevalence rates for a range of developmental impairments have been difficult to establish. Since related studies have used different methodological approaches, direct comparisons of the prevalence of developmental delays are difficult. The understanding of the key factors affecting child development, especially in preschool aged children remains limited. We used data from school entry examinations in Bavaria to measure the prevalence of developmental impairments in pre-school children beginning primary school in 1997-2009.
2016-01-08T15:10:17Z
2016-01-08T15:10:17Z
2012
Article
Individual development of preschool children-prevalences and determinants of delays in Germany: a cross-sectional study in Southern Bavaria. 2012, 12:188 BMC Pediatr
1471-2431
23216820
10.1186/1471-2431-12-188
http://hdl.handle.net/10033/593100
BMC pediatrics
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/5954362019-08-30T11:36:32Zcom_10033_267632com_10033_211390col_10033_267633
A feasibility trial to examine the social norms approach for the prevention and reduction of licit and illicit drug use in European University and college students.
Pischke, Claudia R
Zeeb, Hajo
van Hal, Guido
Vriesacker, Bart
McAlaney, John
Bewick, Bridgette M
Akvardar, Yildiz
Guillén-Grima, Francisco
Orosova, Olga
Salonna, Ferdinand
Kalina, Ondrej
Stock, Christiane
Helmer, Stefanie M
Mikolajczyk, Rafael T
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Adolescent
Adult
Feasibility Studies
Female
Germany
Health Knowledge, Attitudes, Practice
Health Promotion
Humans
Male
Social Environment
Street Drugs
Students
Substance-Related Disorders
Surveys and Questionnaires
Treatment Outcome
Universities
Young Adult
Incorrect perceptions of high rates of peer alcohol and tobacco use are predictive of increased personal use in student populations. Correcting misperceptions by providing feedback has been shown to be an effective intervention for reducing licit drug use. It is currently unknown if social norms interventions are effective in preventing and reducing illicit drug use in European students. The purpose of this paper is to describe the design of a multi-site cluster controlled trial of a web-based social norms intervention aimed at reducing licit and preventing illicit drug use in European university students.
2016-02-02T12:50:48Z
2016-02-02T12:50:48Z
2012
Article
A feasibility trial to examine the social norms approach for the prevention and reduction of licit and illicit drug use in European University and college students. 2012, 12:882 BMC Public Health
1471-2458
23075043
10.1186/1471-2458-12-882
http://hdl.handle.net/10033/595436
BMC public health
en
oai:repository.helmholtz-hzi.de:10033/5966882019-08-30T11:26:42Zcom_10033_211390col_10033_211409
Labour duration and timing of interventions in women planning vaginal birth after caesarean section.
Grylka-Baeschlin, Susanne
Petersen, Antje
Karch, André
Gross, Mechthild M
understanding the labour characteristics of women attempting vaginal birth after caesarean (VBAC) may suggest how to improve intrapartum management and may enhance success rates. Promoting VBAC is a relevant factor in decreasing overall caesarean section (c-section) rates. However, the labour processes of women attempting VBAC are not well investigated. The aim of this paper is to compare multiparae planning a first VBAC (pVBAC) with primiparae and with multiparae planning a second vaginal birth, all starting to give birth vaginally, with regard to (a) perinatal characteristics, (b) the timing of intrapartal spontaneous rupture of membranes (SROM) and of interventions, and (c) labour duration, with respect to the first and second stages.
2016-02-19T08:57:04Z
2016-02-19T08:57:04Z
2015-11-10
Article
Labour duration and timing of interventions in women planning vaginal birth after caesarean section. 2015: Midwifery
1532-3099
26681573
10.1016/j.midw.2015.11.004
http://hdl.handle.net/10033/596688
Midwifery
ENG
oai:repository.helmholtz-hzi.de:10033/5971962019-08-30T11:37:23Zcom_10033_211390col_10033_211409
Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa.
Fähnrich, C
Denecke, K
Adeoye, O O
Benzler, J
Claus, H
Kirchner, G
Mall, S
Richter, R
Schapranow, M P
Schwarz, N
Tom-Aba, D
Uflacker, M
Poggensee, G
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Africa, Western
Contact Tracing
Disease Outbreaks
Health Information Systems
Hemorrhagic Fever, Ebola
Humans
Population Surveillance
In the context of controlling the current outbreak of Ebola virus disease (EVD), the World Health Organization claimed that 'critical determinant of epidemic size appears to be the speed of implementation of rigorous control measures', i.e. immediate follow-up of contact persons during 21 days after exposure, isolation and treatment of cases, decontamination, and safe burials. We developed the Surveillance and Outbreak Response Management System (SORMAS) to improve efficiency and timeliness of these measures. We used the Design Thinking methodology to systematically analyse experiences from field workers and the Ebola Emergency Operations Centre (EOC) after successful control of the EVD outbreak in Nigeria. We developed a process model with seven personas representing the procedures of EVD outbreak control. The SORMAS system architecture combines latest In-Memory Database (IMDB) technology via SAP HANA (in-memory, relational database management system), enabling interactive data analyses, and established SAP cloud tools, such as SAP Afaria (a mobile device management software). The user interface consists of specific front-ends for smartphones and tablet devices, which are independent from physical configurations. SORMAS allows real-time, bidirectional information exchange between field workers and the EOC, ensures supervision of contact follow-up, automated status reports, and GPS tracking. SORMAS may become a platform for outbreak management and improved routine surveillance of any infectious disease. Furthermore, the SORMAS process model may serve as framework for EVD outbreak modeling.
2016-02-25T10:50:04Z
2016-02-25T10:50:04Z
2015
Article
Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa. 2015, 20 (12): Euro Surveill.
1560-7917
25846493
http://hdl.handle.net/10033/597196
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
en
oai:repository.helmholtz-hzi.de:10033/6008472019-08-30T11:26:13Zcom_10033_267632com_10033_211390col_10033_267633
Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units.
Karch, André
Castell, Stefanie
Schwab, Frank
Geffers, Christine
Bongartz, Hannah
Brunkhorst, Frank M
Gastmeier, Petra
Mikolajczyk, Rafael
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Blood
Critical Care
Epidemiological Monitoring
Humans
Intensive Care Units
Microbiological Techniques
Sepsis
Specimen Handling
Early and appropriate blood culture sampling is recommended as a standard of care for patients with suspected bloodstream infections (BSI) but is rarely taken into account when quality indicators for BSI are evaluated. To date, sampling of about 100 to 200 blood culture sets per 1,000 patient-days is recommended as the target range for blood culture rates. However, the empirical basis of this recommendation is not clear. The aim of the current study was to analyze the association between blood culture rates and observed BSI rates and to derive a reference threshold for blood culture rates in intensive care units (ICUs). This study is based on data from 223 ICUs taking part in the German hospital infection surveillance system. We applied locally weighted regression and segmented Poisson regression to assess the association between blood culture rates and BSI rates. Below 80 to 90 blood culture sets per 1,000 patient-days, observed BSI rates increased with increasing blood culture rates, while there was no further increase above this threshold. Segmented Poisson regression located the threshold at 87 (95% confidence interval, 54 to 120) blood culture sets per 1,000 patient-days. Only one-third of the investigated ICUs displayed blood culture rates above this threshold. We provided empirical justification for a blood culture target threshold in ICUs. In the majority of the studied ICUs, blood culture sampling rates were below this threshold. This suggests that a substantial fraction of BSI cases might remain undetected; reporting observed BSI rates as a quality indicator without sufficiently high blood culture rates might be misleading.
2016-03-08T10:07:42Z
2016-03-08T10:07:42Z
2015-02
Article
Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units. 2015, 53 (2):648-52 J. Clin. Microbiol.
1098-660X
25520442
10.1128/JCM.02944-14
http://hdl.handle.net/10033/600847
Journal of clinical microbiology
en
oai:repository.helmholtz-hzi.de:10033/6050142019-08-30T11:30:58Zcom_10033_267632com_10033_211390col_10033_267633
Bloodstream infections, antibiotic resistance and the practice of blood culture sampling in Germany: study design of a Thuringia-wide prospective population-based study (AlertsNet).
Karch, André
Schmitz, Roland P
Rißner, Florian
Castell, Stefanie
Töpel, Sandra
Jakob, Matthias
Brunkhorst, Frank M
Mikolajczyk, Rafael
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Bloodstream infections are a major cause of death worldwide; blood culture (BC) sampling remains the most important tool for their diagnosis. Current data suggest that BC rates in German hospitals are considerably lower than recommended; this points to shortfalls in the application of microbiological analyses. Since early and appropriate BC diagnostics are associated with reduced case fatality rates and a shorter duration of antimicrobial therapy, a multicomponent study for the improvement of BC diagnostics was developed.
2016-04-11T12:00:00Z
2016-04-11T12:00:00Z
2015
Article
Bloodstream infections, antibiotic resistance and the practice of blood culture sampling in Germany: study design of a Thuringia-wide prospective population-based study (AlertsNet). 2015, 5 (12):e009095 BMJ Open
2044-6055
26671957
10.1136/bmjopen-2015-009095
http://hdl.handle.net/10033/605014
BMJ open
en
oai:repository.helmholtz-hzi.de:10033/6060482019-08-30T11:32:16Zcom_10033_267632com_10033_211390col_10033_267633
Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons.
Ohlmeier, Christoph
Mikolajczyk, Rafael T
Frick, Johann
Prütz, Franziska
Haverkamp, Wilhelm
Garbe, Edeltraut
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Heart failure (HF) continues to be a leading cause of morbidity and mortality in industrialized countries. Data on the epidemiology of HF are largely lacking for Germany. The aims of this study were to estimate the incidence and prevalence of HF in Germany, to estimate 1-year all-cause mortality in patients who received their first diagnosis of HF in hospital and to assess related risk factors.
2016-04-20T11:35:15Z
2016-04-20T11:35:15Z
2015-08
Article
Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons. 2015, 104 (8):688-96 Clin Res Cardiol
1861-0692
25777937
10.1007/s00392-015-0841-4
http://hdl.handle.net/10033/606048
Clinical research in cardiology : official journal of the German Cardiac Society
en
oai:repository.helmholtz-hzi.de:10033/6077312019-08-30T11:24:31Zcom_10033_267632com_10033_211390col_10033_267633
Predictors of the patient-centered outcomes of surgical carpal tunnel release - a prospective cohort study.
Conzen, Catharina
Conzen, Michael
Rübsamen, Nicole
Mikolajczyk, Rafael
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Carpal tunnel syndrome (CTS) causes a substantial burden of disease in society. While CTS can be resolved by surgical carpal tunnel release, it still remains unclear as to what degree outcomes depend on patients' characteristics. This study assesses patient-centered outcomes after surgical carpal tunnel release in a large outpatient clinic in Germany.
2016-05-03T08:59:29Z
2016-05-03T08:59:29Z
2016
Article
Predictors of the patient-centered outcomes of surgical carpal tunnel release - a prospective cohort study. 2016, 17 (1):190 BMC Musculoskelet Disord
1471-2474
27121725
10.1186/s12891-016-1046-3
http://hdl.handle.net/10033/607731
BMC musculoskeletal disorders
en
oai:repository.helmholtz-hzi.de:10033/6077382019-08-30T11:28:23Zcom_10033_267632com_10033_211390col_10033_267633
Care for MRSA carriers in the outpatient sector: a survey among MRSA carriers and physicians in two regions in Germany.
Raupach-Rosin, Heike
Rübsamen, Nicole
Szkopek, Sebastian
Schmalz, Oliver
Karch, André
Mikolajczyk, Rafael T
Castell, Stefanie
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Little is known about the management of methicillin-resistant Staphylococcus aureus (MRSA) carriers in the German outpatient sector and about the impact of MRSA on their daily life. Reimbursement for MRSA related costs in the German outpatient sector is available since 2012, but its impact has not been studied yet. The aim of the study was to analyze the outpatient management of MRSA carriers from both, physicians' and MRSA carriers' perspective.
2016-05-03T13:32:03Z
2016-05-03T13:32:03Z
2016
Article
Care for MRSA carriers in the outpatient sector: a survey among MRSA carriers and physicians in two regions in Germany. 2016, 16 (1):184 BMC Infect. Dis.
1471-2334
27112442
10.1186/s12879-016-1503-5
http://hdl.handle.net/10033/607738
BMC infectious diseases
en
oai:repository.helmholtz-hzi.de:10033/6117732019-08-30T11:30:58Zcom_10033_211390col_10033_211409
Impact of HIV infection on treatment outcome of tuberculosis in Europe.
Karo, Basel
Krause, Gerard
Hollo, Vahur
van der Werf, Marieke J
Castell, Stefanie
Hamouda, Osamah
Haas, Walter
1Department for Infectious Disease Epidemiology, Robert Koch Institute (RKI), Berlin, Germany.
The effect of HIV on tuberculosis (TB) treatment outcomes has not been well established. We aimed to assess the impact of HIV infection on TB treatment outcomes by using data from notifiable disease surveillance in Europe.
2016-06-06T08:27:02Z
2016-06-06T08:27:02Z
2016-04-24
Article
Impact of HIV infection on treatment outcome of tuberculosis in Europe. 2016, 30 (7):1089-98 AIDS
1473-5571
26752278
10.1097/QAD.0000000000001016
http://hdl.handle.net/10033/611773
AIDS (London, England)
en
oai:repository.helmholtz-hzi.de:10033/6144442019-08-30T11:31:23Zcom_10033_267632com_10033_211390col_10033_267633
What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies.
Betran, Ana Pilar
Torloni, Maria Regina
Zhang, Jun
Ye, Jiangfeng
Mikolajczyk, Rafael T
Deneux-Tharaux, Catherine
Oladapo, Olufemi Taiwo
Souza, João Paulo
Tunçalp, Özge
Vogel, Joshua Peter
Gülmezoglu, Ahmet Metin
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Cesarean Section
Cross-Sectional Studies
Female
Humans
Infant
Infant Mortality
Infant, Newborn
Maternal Mortality
Morbidity
Pregnancy
Pregnancy Outcome
Socioeconomic Factors
World Health Organization
In 1985, WHO stated that there was no justification for caesarean section (CS) rates higher than 10-15% at population-level. While the CS rates worldwide have continued to increase in an unprecedented manner over the subsequent three decades, concern has been raised about the validity of the 1985 landmark statement. We conducted a systematic review to identify, critically appraise and synthesize the analyses of the ecologic association between CS rates and maternal, neonatal and infant outcomes. Four electronic databases were searched for ecologic studies published between 2000 and 2014 that analysed the possible association between CS rates and maternal, neonatal or infant mortality or morbidity. Two reviewers performed study selection, data extraction and quality assessment independently. We identified 11,832 unique citations and eight studies were included in the review. Seven studies correlated CS rates with maternal mortality, five with neonatal mortality, four with infant mortality, two with LBW and one with stillbirths. Except for one, all studies were cross-sectional in design and five were global analyses of national-level CS rates versus mortality outcomes. Although the overall quality of the studies was acceptable; only two studies controlled for socio-economic factors and none controlled for clinical or demographic characteristics of the population. In unadjusted analyses, authors found a strong inverse relationship between CS rates and the mortality outcomes so that maternal, neonatal and infant mortality decrease as CS rates increase up to a certain threshold. In the eight studies included in this review, this threshold was at CS rates between 9 and 16%. However, in the two studies that adjusted for socio-economic factors, this relationship was either weakened or disappeared after controlling for these confounders. CS rates above the threshold of 9-16% were not associated with decreases in mortality outcomes regardless of adjustments. Our findings could be interpreted to mean that at CS rates below this threshold, socio-economic development may be driving the ecologic association between CS rates and mortality. On the other hand, at rates higher than this threshold, there is no association between CS and mortality outcomes regardless of adjustment. The ecological association between CS rates and relevant morbidity outcomes needs to be evaluated before drawing more definite conclusions at population level.
2016-06-23T13:35:01Z
2016-06-23T13:35:01Z
2015
Article
What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies. 2015, 12:57 Reprod Health
1742-4755
26093498
10.1186/s12978-015-0043-6
http://hdl.handle.net/10033/614444
Reproductive health
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6184202019-08-30T11:24:31Zcom_10033_211390col_10033_211409
Advising vaccinations for the elderly: a cross-sectional survey on differences between general practitioners and physician assistants in Germany.
Klett-Tammen, Carolina Judith
Krause, Gerard
von Lengerke, Thomas
Castell, Stefanie
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
In Germany, the coverage of officially recommended vaccinations for the elderly is below a desirable level. It is known that advice provided by General Practitioners and Physician Assistants influences the uptake in patients ≥60 years. Therefore, the predictors of advice-giving behavior by these professions should be investigated to develop recommendations for possible actions for improvement.
2016-08-16T08:17:08Z
2016-08-16T08:17:08Z
2016
Article
Advising vaccinations for the elderly: a cross-sectional survey on differences between general practitioners and physician assistants in Germany. 2016, 17:98 BMC Fam Pract
1471-2296
27473612
10.1186/s12875-016-0502-3
http://hdl.handle.net/10033/618420
BMC family practice
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6184342019-08-30T11:24:31Zcom_10033_211390col_10033_211409
Contact diaries versus wearable proximity sensors in measuring contact patterns at a conference: method comparison and participants' attitudes.
Smieszek, Timo
Castell, Stefanie
Barrat, Alain
Cattuto, Ciro
White, Peter J
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Studies measuring contact networks have helped to improve our understanding of infectious disease transmission. However, several methodological issues are still unresolved, such as which method of contact measurement is the most valid. Further, complete network analysis requires data from most, ideally all, members of a network and, to achieve this, acceptance of the measurement method. We aimed at investigating measurement error by comparing two methods of contact measurement - paper diaries vs. wearable proximity sensors - that were applied concurrently to the same population, and we measured acceptability.
2016-08-16T08:37:06Z
2016-08-16T08:37:06Z
2016
Article
Contact diaries versus wearable proximity sensors in measuring contact patterns at a conference: method comparison and participants' attitudes. 2016, 16:341 BMC Infect. Dis.
1471-2334
27449511
10.1186/s12879-016-1676-y
http://hdl.handle.net/10033/618434
BMC infectious diseases
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6205632019-08-30T11:30:58Zcom_10033_267632com_10033_211390col_10033_267633
Top 25 Global Causes of Disability-Adjusted Life-Years (DALYs) in Children Younger Than 5 Years, Both Sexes, 1990 and 2013
The Global Burden of Disease Pediatrics Collaboration
Karch, André
et al.
Institute for Health Metrics and Evaluation, University of Washington, 2301 Fifth Ave, Ste 600, Seattle, WA 98121
mportance The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Evidence Review Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. Findings Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. Conclusions and Relevance Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.
2016-10-25T14:32:57Z
2016-10-25T14:32:57Z
2016-10-25
Article
Global Burden of Disease Pediatrics Collaboration. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study. JAMA Pediatr. 2016;170(3):267-287. doi:10.1001/jamapediatrics.2015.4276
2168-6211
26810619
10.1001/jamapediatrics.2015.4276
http://hdl.handle.net/10033/620563
JAMA Pediadrics
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
JAMA Network
oai:repository.helmholtz-hzi.de:10033/6205422019-08-30T11:27:16Zcom_10033_267632com_10033_211390col_10033_267633
Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate?
Zapf, Antonia
Castell, Stefanie
Morawietz, Lars
Karch, André
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Reliability of measurements is a prerequisite of medical research. For nominal data, Fleiss' kappa (in the following labelled as Fleiss' K) and Krippendorff's alpha provide the highest flexibility of the available reliability measures with respect to number of raters and categories. Our aim was to investigate which measures and which confidence intervals provide the best statistical properties for the assessment of inter-rater reliability in different situations.
2016-10-07T10:52:37Z
2016-10-07T10:52:37Z
2016
Article
Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate? 2016, 16:93 BMC Med Res Methodol
1471-2288
27495131
10.1186/s12874-016-0200-9
http://hdl.handle.net/10033/620542
BMC medical research methodology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6205542019-08-30T11:33:57Zcom_10033_267632com_10033_211390col_10033_267633
Alcohol Drinking in University Students Matters for Their Self-Rated Health Status: A Cross-sectional Study in Three European Countries.
Mikolajczyk, Rafael T
Sebena, Rene
Warich, Julia
Naydenova, Vihra
Dudziak, Urszula
Orosova, Olga
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Alcohol drinking was linked to self-rated health in different populations, but the observed association was inconsistent. We studied the association among university students across three European countries with different patterns of drinking.
2016-10-18T13:23:00Z
2016-10-18T13:23:00Z
2016
Article
Alcohol Drinking in University Students Matters for Their Self-Rated Health Status: A Cross-sectional Study in Three European Countries. 2016, 4:210 Front Public Health
27730122
10.3389/fpubh.2016.00210
http://hdl.handle.net/10033/620554
Frontiers in public health
ENG
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6206482019-08-30T11:27:46Zcom_10033_267632com_10033_211390col_10033_267633
Infection prevention at preschool age - What is reasonable? [Infektionsprävention im Kindergartenalter -Was ist sinnvoll?]
Schlinkmann, K.M.
Raupach-Rosin, H.
Hübner, J.,
Akute respiratorische und gastrointestinale Infektionen stellen die am weitesten verbreiteten Infektionserkrankungen im Kindesalter dar und generieren hohe Kosten. Bezüglich des Immunsystems ist neben der Infektionsabwehr auch die Immuntoleranz zu beachten. Daraus ergibt sich die Frage nach einer Ausgestaltung der Infektionsprävention, bei der negative Effekte auf die Immuntoleranz vermieden werden. Eine Handreichung dazu bieten die Hygienehypothese und die „old friends“ Theorie, die die Unterschiede in der Rolle der Pathogene für die Entwicklung des Immunsystems mit der gemeinsamen Evolution erklärt. Daraus lassen sich Implikationen für die Infektionsprävention ableiten: Bezüglich der Mikroorganismen, die für die Ausbildung der Toleranz verantwortlich sind (sog. old friends, z.B. Mikroorganismen, die das Mikrobiom bilden), können sich übertriebene Hygienemaßnahmen negativ auswirken. Pathogene, die eine dauerhafte Immunität auslösen oder tödlich verlaufen können (sog. crowd infections, z.B. Masern) haben diese Rolle nicht – angesichts der Risiken sollte hier eine spezifische Prävention mittels Impfung erfolgen. Die meisten akuten respiratorischen und gastrointestinalen Infektionen fallen in eine weitere Gruppe ohne bleibende Immunantwort (z.B. Rhinovirusinfektionen), deren Rolle für die Immuntoleranz bisher unklar ist. Für diese Infektionen können unspezifische Präventionsmaßnahmen eingesetzt werden. Gesicherte Evidenz liegt für die Effektivität von Handhygiene sowie von Barriere- und Isolationsmaßnahmen zur Verhinderung der Infektionsübertragung vor. Hingegen gibt es für Maßnahmen zur Stärkung der Immunität keine oder bestenfalls kontroverse Evidenz. Der traditionelle Zusammenhang zwischen Kälte und Erkältung erscheint fraglich und daher auch die Bedeutsamkeit der entsprechenden Präventionsmaßnahmen. Unklar ist, in welchem Umfang einzelne Maßnahmen von Eltern eingesetzt werden, und ob die Exposition gegenüber den leichten akuten Infektionen doch immunologisch eine Rolle spielt. 2
2016-12-08T11:34:46Z
2016-12-08T11:34:46Z
2016-01
2016-12-08
Article
http://hdl.handle.net/10033/620648
de
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6206922019-08-30T11:35:13Zcom_10033_267632com_10033_211390com_10033_620659com_10033_311308col_10033_267633col_10033_620661col_10033_620721
Analysis of Practical Identifiability of a Viral Infection Model.
Nguyen, Van Kinh
Klawonn, Frank
Mikolajczyk, Rafael
Hernandez-Vargas, Esteban Abelardo
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Mathematical modelling approaches have granted a significant contribution to life sciences and beyond to understand experimental results. However, incomplete and inadequate assessments in parameter estimation practices hamper the parameter reliability, and consequently the insights that ultimately could arise from a mathematical model. To keep the diligent works in modelling biological systems from being mistrusted, potential sources of error must be acknowledged. Employing a popular mathematical model in viral infection research, existing means and practices in parameter estimation are exemplified. Numerical results show that poor experimental data is a main source that can lead to erroneous parameter estimates despite the use of innovative parameter estimation algorithms. Arbitrary choices of initial conditions as well as data asynchrony distort the parameter estimates but are often overlooked in modelling studies. This work stresses the existence of several sources of error buried in reports of modelling biological systems, voicing the need for assessing the sources of error, consolidating efforts in solving the immediate difficulties, and possibly reconsidering the use of mathematical modelling to quantify experimental data.
2017-01-11T09:39:52Z
2017-01-11T09:39:52Z
2016
Article
Analysis of Practical Identifiability of a Viral Infection Model. 2016, 11 (12):e0167568 PLoS ONE
1932-6203
28036339
10.1371/journal.pone.0167568
http://hdl.handle.net/10033/620692
PloS one
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6208842019-08-30T11:29:47Zcom_10033_267632com_10033_211390col_10033_267633
Deficits in knowledge, attitude, and practice towards blood culture sampling: results of a nationwide mixed-methods study among inpatient care physicians in Germany.
Raupach-Rosin, Heike
Duddeck, Arne
Gehrlich, Maike
Helmke, Charlotte
Huebner, Johannes
Pletz, Mathias W
Mikolajczyk, Rafael T
Karch, André
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Blood culture (BC) sampling rates in Germany are considerably lower than recommended. Aim of our study was to assess knowledge, attitudes, and practice of physicians in Germany regarding BC diagnostics.
2017-04-04T13:41:40Z
2017-04-04T13:41:40Z
2017-02-15
Article
Deficits in knowledge, attitude, and practice towards blood culture sampling: results of a nationwide mixed-methods study among inpatient care physicians in Germany. 2017 Infection
1439-0973
28205159
10.1007/s15010-017-0990-7
http://hdl.handle.net/10033/620884
Infection
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6208922019-08-30T11:29:47Zcom_10033_267632com_10033_211390com_10033_620601col_10033_267633col_10033_211409col_10033_620603
Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design.
Rübsamen, Nicole
Akmatov, Manas K
Castell, Stefanie
Karch, André
Mikolajczyk, Rafael T
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Increasing availability of the Internet allows using only online data collection for more epidemiological studies. We compare response patterns in a population-based health survey using two survey designs: mixed-mode (choice between paper-and-pencil and online questionnaires) and online-only design (without choice).
2017-04-07T10:09:11Z
2017-04-07T10:09:11Z
2017
Article
Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design. 2017, 14:4 Emerg Themes Epidemiol
28344629
10.1186/s12982-017-0058-2
http://hdl.handle.net/10033/620892
Emerging themes in epidemiology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209122019-08-30T11:31:49Zcom_10033_267632com_10033_211390col_10033_267633
Current and future effects of varicella and herpes zoster vaccination in Germany - Insights from a mathematical model in a country with universal varicella vaccination.
Horn, Johannes
Karch, André
Damm, Oliver
Kretzschmar, Mirjam E
Siedler, Anette
Ultsch, Bernhard
Weidemann, Felix
Wichmann, Ole
Hengel, Hartmut
Greiner, Wolfgang
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Varicella zoster virus (VZV) is primarily known for causing varicella in childhood, but can reactivate again as herpes zoster (HZ) after a period of latency, mainly in persons older than 50 years. Universal varicella vaccination was introduced in Germany in 2004, while HZ vaccination has not been recommended yet. We aimed to quantify the potential long-term effects of universal childhood varicella vaccination and HZ vaccination of the elderly on varicella and HZ incidence in Germany over a time horizon of 100 years, using a transmission model calibrated to pre-vaccination data and validated against early post-vaccination data. Using current vaccination coverage rates of 87% (64%) with one (two) varicella vaccine dose(s), the model predicts a decrease in varicella cases by 89% for the year 2015. In the long run, the incidence reduction will stabilize at about 70%. Under the assumption of the boosting hypothesis of improved HZ protection caused by exposure to VZV, the model predicts a temporary increase in HZ incidence of up to 20% for around 50 years. HZ vaccination of the elderly with an assumed coverage of 20% has only limited effects in counteracting this temporary increase in HZ incidence. However, HZ incidence is shown to decrease in the long-term by 58% as vaccinated individuals get older and finally reach age-classes with originally high HZ incidence. Despite substantial uncertainties around several key variables, the model's results provide valuable insights that support decision-making regarding national VZV vaccination strategies.
2017-05-08T13:19:47Z
2017-05-08T13:19:47Z
2016-07-02
Article
Current and future effects of varicella and herpes zoster vaccination in Germany - Insights from a mathematical model in a country with universal varicella vaccination. 2016, 12 (7):1766-76 Hum Vaccin Immunother
2164-554X
26835890
10.1080/21645515.2015.1135279
http://hdl.handle.net/10033/620912
Human vaccines & immunotherapeutics
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209202019-08-30T11:29:47Zcom_10033_267632com_10033_211390col_10033_267633
Incidence and comparison of retrospective and prospective data on respiratory and gastrointestinal infections in German households.
Schlinkmann, Kristin Maria
Bakuli, Abhishek
Mikolajczyk, Rafael T
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Acute respiratory infections (ARI) and acute gastrointestinal infections (AGI) are the most common childhood infections, and corresponding data can either be collected prospectively or retrospectively. The aim of this study was to estimate the incidence of respiratory and gastrointestinal episodes in German households with children attending day care and to compare results of prospective and retrospective data collection.
2017-05-17T09:39:00Z
2017-05-17T09:39:00Z
2017-05-11
Article
Incidence and comparison of retrospective and prospective data on respiratory and gastrointestinal infections in German households. 2017, 17 (1):336 BMC Infect. Dis.
1471-2334
28490316
10.1186/s12879-017-2434-5
http://hdl.handle.net/10033/620920
BMC infectious diseases
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209232019-08-30T11:29:47Zcom_10033_267632com_10033_211390col_10033_267633
Transcranial doppler sonography is not a valid diagnostic tool for detection of basilar artery stenosis or in-stent restenosis: a retrospective diagnostic study.
Koh, Woori
Kallenberg, Kai
Karch, André
Frank, Tobias
Knauth, Michael
Bähr, Mathias
Liman, Jan
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
There are contradictory reports concerning the validity of transcranial sonography (TCD and TCCS) for examinations of the basilar artery. Here we investigated sensitivity and specificity of transcranial sonography for the detection of basilar artery stenosis and in-stent-restenosis compared to cerebral angiography.
2017-05-17T13:43:28Z
2017-05-17T13:43:28Z
2017-05-11
Article
Transcranial doppler sonography is not a valid diagnostic tool for detection of basilar artery stenosis or in-stent restenosis: a retrospective diagnostic study. 2017, 17 (1):89 BMC Neurol
1471-2377
28490351
10.1186/s12883-017-0872-8
http://hdl.handle.net/10033/620923
BMC neurology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209252019-08-30T11:31:23Zcom_10033_267632com_10033_211390col_10033_267633
Deciding on the mode of birth after a previous caesarean section - An online survey investigating women's preferences in Western Switzerland.
Bonzon, Magali
Gross, Mechthild M
Karch, André
Grylka-Baeschlin, Susanne
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
promoting vaginal births after caesarean section (VBAC) for eligible women and increasing rates of successful VBACs are the best strategies to reduce the number of repeat caesarean sections (CS). Knowledge of factors that are associated with women's decision-making around mode of birth after CS is important when developing strategies to promote VBAC. This study assessed which factors are associated with women's preferences for VBAC versus elective repeat caesarean section (ERCS) in a new pregnancy after one previous caesarean in Switzerland.
2017-05-22T10:59:58Z
2017-05-22T10:59:58Z
2017-04-21
Article
Deciding on the mode of birth after a previous caesarean section - An online survey investigating women's preferences in Western Switzerland. 2017, 50:219-227 Midwifery
1532-3099
28478374
10.1016/j.midw.2017.04.005
http://hdl.handle.net/10033/620925
Midwifery
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209332019-08-30T11:29:47Zcom_10033_267632com_10033_211390col_10033_267633
Early versus Late Admission to Labor Affects Labor Progression and Risk of Cesarean Section in Nulliparous Women.
Mikolajczyk, Rafael T
Zhang, Jun
Grewal, Jagteshwar
Chan, Linda C
Petersen, Antje
Gross, Mechthild M
Helmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Rates of cesarean section increase worldwide, and the components of this increase are partially unknown. A strong role is prescribed to dystocia, and at the same time, the diagnosis of dystocia is highly subjective. Previous studies indicated that risk of cesarean is higher when women are admitted to the hospital early in the labor.
2017-06-06T10:50:32Z
2017-06-06T10:50:32Z
2016
Article
Early versus Late Admission to Labor Affects Labor Progression and Risk of Cesarean Section in Nulliparous Women. 2016, 3:26 Front Med (Lausanne)
27446924
10.3389/fmed.2016.00026
http://hdl.handle.net/10033/620933
Frontiers in medicine
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6209542019-08-30T11:26:13Zcom_10033_267632com_10033_211390com_10033_620644col_10033_267633col_10033_620647
Sociodemographic determinants of spatial disparities in early childhood caries: An ecological analysis in Braunschweig, Germany.
Meyer, Frederic
Karch, André
Schlinkmann, Kristin Maria
Dreesman, Johannes
Horn, Johannes
Rübsamen, Nicole
Sudradjat, Henny
Schubert, Rainer
Mikolajczyk, Rafael T
Helmholtz Centre for infection research, Inhoffenstr.7, 38124 Braunschweig, Germany.
To identify spatial disparities in dental caries experience (measured by dmft (decayed missing filled teeth) index) of children in the city of Braunschweig and to evaluate whether these disparities can be explained by sociodemographic characteristics.
2017-06-15T12:59:58Z
2017-06-15T12:59:58Z
2017-05-26
Article
Sociodemographic determinants of spatial disparities in early childhood caries: An ecological analysis in Braunschweig, Germany. 2017 Community Dent Oral Epidemiol
1600-0528
28547864
10.1111/cdoe.12308
http://hdl.handle.net/10033/620954
Community dentistry and oral epidemiology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210132019-08-30T11:26:13Zcom_10033_211390com_10033_620601com_10033_620652col_10033_620666col_10033_211409col_10033_620603
Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study.
Akmatov, Manas K
Röber, Nadja
Ahrens, Wolfgang
Flesch-Janys, Dieter
Fricke, Julia
Greiser, Halina
Günther, Kathrin
Kaaks, Rudolf
Kemmling, Yvonne
Krone, Bastian
Linseisen, Jakob
Meisinger, Christa
Moebus, Susanne
Obi, Nadia
Guzman, Carlos A
Conrad, Karsten
Pessler, Frank
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders.
2017-07-14T13:15:38Z
2017-07-14T13:15:38Z
2017-06-06
Article
Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders-findings of a multicenter population-based study. 2017, 19 (1):127 Arthritis Res. Ther.
1478-6362
28587625
10.1186/s13075-017-1338-5
http://hdl.handle.net/10033/621013
Arthritis research & therapy
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210162019-08-30T11:33:30Zcom_10033_267632com_10033_211390col_10033_267633
Structure of the Escherichia coli ProQ RNA-binding protein.
Gonzalez, Grecia M
Hardwick, Steven W
Maslen, Sarah L
Skehel, J Mark
Holmqvist, Erik
Vogel, Jörg
Bateman, Alex
Luisi, Ben F
Broadhurst, R William
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
3' Untranslated Regions
Binding Sites
Escherichia coli Proteins
Host Factor 1 Protein
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Protein Domains
RNA-Binding Proteins
The protein ProQ has recently been identified as a global small noncoding RNA-binding protein in Salmonella, and a similar role is anticipated for its numerous homologs in divergent bacterial species. We report the solution structure of Escherichia coli ProQ, revealing an N-terminal FinO-like domain, a C-terminal domain that unexpectedly has a Tudor domain fold commonly found in eukaryotes, and an elongated bridging intradomain linker that is flexible but nonetheless incompressible. Structure-based sequence analysis suggests that the Tudor domain was acquired through horizontal gene transfer and gene fusion to the ancestral FinO-like domain. Through a combination of biochemical and biophysical approaches, we have mapped putative RNA-binding surfaces on all three domains of ProQ and modeled the protein's conformation in the apo and RNA-bound forms. Taken together, these data suggest how the FinO, Tudor, and linker domains of ProQ cooperate to recognize complex RNA structures and serve to promote RNA-mediated regulation.
2017-07-21T08:29:01Z
2017-07-21T08:29:01Z
2017-05
Article
Structure of the Escherichia coli ProQ RNA-binding protein. 2017, 23 (5):696-711 RNA
1469-9001
28193673
10.1261/rna.060343.116
http://hdl.handle.net/10033/621016
RNA (New York, N.Y.)
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210212019-08-22T12:38:22Zcom_10033_267632com_10033_211390col_10033_267633
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Child Mortality
Communicable Diseases
Global Health
Humans
Infant
Infant Mortality
Malaria
Stillbirth
Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time.
2017-07-26T14:14:57Z
2017-07-26T14:14:57Z
2016-10-08
Article
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. 2016, 388 (10053):1725-1774 Lancet
1474-547X
27733285
10.1016/S0140-6736(16)31575-6
http://hdl.handle.net/10033/621021
Lancet (London, England)
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210222019-08-30T11:34:22Zcom_10033_267632com_10033_211390col_10033_267633
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
GBD 2015 Child Mortality Collaborators
Karch, A.
Bayes Theorem
Cost of Illness
Disabled Persons
Global Health
Humans
Incidence
Prevalence
Quality-Adjusted Life Years
Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
2017-07-28T09:45:06Z
2017-07-28T09:45:06Z
2016
Article
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. 2016, 388 (10053):1545-1602 Lancet
1474-547X
27733282
10.1016/S0140-6736(16)31678-6
http://hdl.handle.net/10033/621022
Lancet (London, England)
en
oai:repository.helmholtz-hzi.de:10033/6210402019-08-30T11:25:11Zcom_10033_211390col_10033_211409
Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy.
Karo, Basel
Krause, Gerard
Castell, Stefanie
Kollan, Christian
Hamouda, Osamah
Haas, Walter
Understanding the immune response to combination antiretroviral therapy (cART) is essential for a clear approach to tuberculosis (TB) preventive therapy. We investigated the immunological recovery in cART-treated HIV-infected patients developing TB compared to those who remained free of TB.
2017-08-03T14:32:51Z
2017-08-03T14:32:51Z
2017-07-25
Article
Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy. 2017, 17 (1):517 BMC Infect. Dis.
1471-2334
28743248
10.1186/s12879-017-2627-y
http://hdl.handle.net/10033/621040
BMC infectious diseases
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210552019-08-30T11:35:39Zcom_10033_211390col_10033_211409
The German National Cohort: aims, study design and organization.
German National Cohort consortium
Krause, Gerard
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Adult
Aged
Chronic Disease
Cohort Studies
Disease
Female
Germany
Humans
Male
Middle Aged
Population Surveillance
Research Design
Young Adult
The German National Cohort (GNC) is a joint interdisciplinary endeavour of scientists from the Helmholtz and the Leibniz Association, universities, and other research institutes. Its aim is to investigate the causes for the development of major chronic diseases, i.e. cardiovascular diseases, cancer, diabetes, neurodegenerative/-psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases, and their pre-clinical stages or functional health impairments. Across Germany, a random sample of the general population will be drawn by 18 regional study centres, including a total of 100,000 women and 100,000 men aged 20-69 years. The baseline assessments include an extensive interview and self-completion questionnaires, a wide range of medical examinations and the collection of various biomaterials. In a random subgroup of 20 % of the participants (n = 40,000) an intensified examination ("Level 2") programme will be performed. In addition, in five of the 18 study centres a total of 30,000 study participants will take part in a magnetic resonance imaging examination programme, and all of these participants will also be offered the intensified Level 2 examinations. After 4-5 years, all participants will be invited for a re-assessment. Information about chronic disease endpoints will be collected through a combination of active follow-up (including questionnaires every 2-3 years) and record linkages. The GNC is planned for an overall duration of 25-30 years. It will provide a major, central resource for population-based epidemiology in Germany, and will help to identify new and tailored strategies for early detection, prediction, and primary prevention of major diseases.
2017-08-16T07:55:14Z
2017-08-16T07:55:14Z
2014-05
Article
The German National Cohort: aims, study design and organization. 2014, 29 (5):371-82 Eur. J. Epidemiol.
1573-7284
24840228
10.1007/s10654-014-9890-7
http://hdl.handle.net/10033/621055
European journal of epidemiology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210562019-08-30T11:34:48Zcom_10033_267632com_10033_211390col_10033_267633
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
GBD 2015 Mortality and Causes of Death Collaborators
Karch, André
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Cause of Death
Communicable Diseases
Global Health
Humans
Life Expectancy
Mortality
Mortality, Premature
Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.
2017-08-16T08:56:57Z
2017-08-16T08:56:57Z
2016-10-08
Article
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. 2016, 388 (10053):1459-1544 Lancet
1474-547X
27733281
10.1016/S0140-6736(16)31012-1
http://hdl.handle.net/10033/621056
Lancet (London, England)
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6210792019-08-30T11:31:49Zcom_10033_267632com_10033_211390col_10033_267633
Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial.
Maier, Ilko L
Schregel, Katharina
Karch, André
Weber-Krueger, Mark
Mikolajczyk, Rafael T
Stahrenberg, Raoul
Gröschel, Klaus
Bähr, Mathias
Knauth, Michael
Psychogios, Marios-Nikos
Wachter, Rolf
Liman, Jan
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. The aim of our study was to evaluate the association between embolic stroke patterns, ESUS, and the new diagnosis of AF. Methods. Stroke etiology and imaging characteristics from patients included in the Find-AF study were obtained. Embolic stroke patterns in CT- or MR-imaging were correlated with the diagnosis of ESUS as well as the short- (on baseline ECG and during 7-day Holter) and long-term (12-month follow-up) diagnosis of AF. Results. From 281 patients included in the Find-AF study, 127 (45.2%) patients with ischemic lesions detected in CT or MRI were included. 26 (20.5%) of these patients had ESUS. At least one embolic stroke pattern was detected in 67 (52.7%) patients. Embolic stroke patterns were not associated with ESUS (OR 1.57, 0.65-3.79, p = 0.317), the short-term (OR 0.64, 0.26-1.58, p = 0.327) or long-term diagnosis of AF (OR 0.72, 0.31-1.68, p = 0.448). Conclusions. This secondary data analysis of the Find-AF study could not provide evidence for an association between embolic stroke patterns, ESUS, and the new diagnosis of AF.
2017-08-29T12:08:37Z
2017-08-29T12:08:37Z
2017
Article
Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial. 2017, 2017:1391843 Stroke Res Treat
2090-8105
28536667
10.1155/2017/1391843
http://hdl.handle.net/10033/621079
Stroke research and treatment
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211012019-08-30T11:30:32Zcom_10033_267632com_10033_211390col_10033_267633
Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine-an interrupted time series analysis from 2005 to 2010 using health insurance data.
Thöne, Kathrin
Horn, Johannes
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital warts (AGWs) were observed, but it was not clear at what level the incidence would stabilize and to what extent herd immunity would be present. Given the relatively low HPV vaccination coverage in Germany, we aimed to assess potential vaccination herd immunity effects in the German setting.
2017-09-11T11:46:45Z
2017-09-11T11:46:45Z
2017-08-14
Article
Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine-an interrupted time series analysis from 2005 to 2010 using health insurance data. 2017, 17 (1):564 BMC Infect. Dis.
1471-2334
28806926
10.1186/s12879-017-2663-7
http://hdl.handle.net/10033/621101
BMC infectious diseases
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211152019-08-30T11:37:24Zcom_10033_267632com_10033_211390col_10033_267633col_10033_211409
Factors associated with attrition in a longitudinal online study: results from the HaBIDS panel.
Rübsamen, Nicole
Akmatov, Manas K
Castell, Stefanie
Karch, André
Mikolajczyk, Rafael T
Hemholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Knowing about predictors of attrition in a panel is important to initiate early measures against loss of participants. We investigated attrition in both early and late phase of an online panel with special focus on preferences regarding mode of participation.
2017-09-22T08:45:58Z
2017-09-22T08:45:58Z
2017-08-31
Article
Factors associated with attrition in a longitudinal online study: results from the HaBIDS panel. 2017, 17 (1):132 BMC Med Res Methodol
1471-2288
28859617
10.1186/s12874-017-0408-3
http://hdl.handle.net/10033/621115
BMC medical research methodology
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211172019-08-30T11:37:24Zcom_10033_267632com_10033_211390col_10033_267633
Cost-effectiveness of human papillomavirus vaccination in Germany.
Damm, Oliver
Horn, Johannes
Mikolajczyk, Rafael T
Kretzschmar, Mirjam E E
Kaufmann, Andreas M
Deleré, Yvonne
Ultsch, Bernhard
Wichmann, Ole
Krämer, Alexander
Greiner, Wolfgang
Hemholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model.
2017-09-22T09:49:34Z
2017-09-22T09:49:34Z
2017
Article
Cost-effectiveness of human papillomavirus vaccination in Germany. 2017, 15:18 Cost Eff Resour Alloc
1478-7547
28878573
10.1186/s12962-017-0080-9
http://hdl.handle.net/10033/621117
Cost effectiveness and resource allocation : C/E
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211332019-08-30T11:25:43Zcom_10033_211390col_10033_211409
Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology.
Bohm, Katrin
Filomena, Angela
Schneiderhan-Marra, Nicole
Krause, Gerard
Sievers, Claudia
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Worldwide about 1.5 million clinical cases of hepatitis A virus (HAV) infections occur every year and increasingly countries are introducing HAV vaccination into the childhood immunization schedule with a single dose instead of the originally licenced two dose regimen. Diagnosis of acute HAV infection is determined serologically by anti-HAV-IgM detection using ELISA. Additionally anti-HAV-IgG can become positive during the early phase of symptoms, but remains detectable after infection and also after vaccination against HAV. Currently no serological marker allows the differentiation of HAV vaccinated individuals and those with a past infection with HAV. Such differentiation would greatly improve evaluation of vaccination campaigns and risk assessment of HAV outbreaks. Here we tested the HAV non-structural protein 2A, important for the capsid assembly, as a biomarker for the differentiation of the immune status in previously infected and vaccinated individuals.
2017-10-10T13:58:49Z
2017-10-10T13:58:49Z
2017-10-13
Article
Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology. 2017, 35 (43):5883-5889 Vaccine
1873-2518
28919226
10.1016/j.vaccine.2017.08.089
http://hdl.handle.net/10033/621133
Vaccine
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211772019-08-30T11:28:23Zcom_10033_267632com_10033_211390col_10033_267633
Effect of Disease Definition on Perceived Burden of Acute Respiratory Infections in Children: A Prospective Cohort Study Based on Symptom Diaries.
Zoch, Beate
Günther, Annette
Karch, André
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsfrschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Acute Disease
Child, Preschool
Humans
Infant
Medical Records
Prospective Studies
Respiratory Tract Infections
Acute respiratory infections (ARIs) are among the most frequent childhood diseases in Western countries. Assessment of ARI episodes for research purposes is usually based on parent-administered retrospective questionnaires or prospective symptom diaries. The aim of our analysis was to compare the effect of ARI definitions on the corresponding disease burden in a prospective cohort study using symptom diaries.
2017-11-16T14:23:51Z
2017-11-16T14:23:51Z
2017-10
Article
Effect of Disease Definition on Perceived Burden of Acute Respiratory Infections in Children: A Prospective Cohort Study Based on Symptom Diaries. 2017, 36 (10):956-961 Pediatr. Infect. Dis. J.
1532-0987
28399058
10.1097/INF.0000000000001604
http://hdl.handle.net/10033/621177
The Pediatric infectious disease journal
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6211882019-08-30T11:33:57Zcom_10033_267632com_10033_211390col_10033_267633
The Risk of Hospitalizations with Injury Diagnoses in a Matched Cohort of Children and Adolescents with and without Attention Deficit/Hyperactivity Disorder in Germany: A Database Study.
Lindemann, Christina
Langner, Ingo
Banaschewski, Tobias
Garbe, Edeltraut
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.
Attention deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder in children and adolescents worldwide, and children with ADHD have elevated risk of injuries. Our aim was to assess the risk of hospitalizations with injury diagnoses and their various subtypes in children and adolescents with newly diagnosed ADHD compared to those without ADHD, as well as to study sex effects on this risk in the setting of the German health care system.
2017-11-29T15:31:56Z
2017-11-29T15:31:56Z
2017
Article
The Risk of Hospitalizations with Injury Diagnoses in a Matched Cohort of Children and Adolescents with and without Attention Deficit/Hyperactivity Disorder in Germany: A Database Study. 2017, 5:220 Front Pediatr
2296-2360
29114538
10.3389/fped.2017.00220
http://hdl.handle.net/10033/621188
Frontiers in pediatrics
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212132019-01-03T07:58:16Zcom_10033_211390com_10033_620601col_10033_211409col_10033_620603
Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori
Filomena, Angela
Pessler, Frank
Akmatov, Manas K
Krause, Gérard
Duffy, Darragh
Gärtner, Barbara
Gerhard, Markus
Albert, Matthew
Joos, Thomas
Schneiderhan-Marra, Nicole
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.
2017-12-20T14:12:08Z
2017-12-20T14:12:08Z
2017-10-30
Article
Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori 2017, 6 (4):14 High-Throughput
2571-5135
29855458
10.3390/ht6040014
http://hdl.handle.net/10033/621213
High-Throughput
http://www.mdpi.com/2571-5135/6/4/14
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212202019-08-30T11:25:11Zcom_10033_211390com_10033_620601col_10033_211409col_10033_620603
Hepatitis B vaccination timing: results from demographic health surveys in 47 countries.
Schweitzer, Aparna
Akmatov, Manas K
Krause, Gerard
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.
Age Factors
Developing Countries
Global Health
Hepatitis B Vaccines
Humans
Immunization Schedule
Socioeconomic Factors
To examine the impact of hepatitis B vaccination schedules and types of vaccines on hepatitis B vaccination timing.
2018-01-03T08:52:06Z
2018-01-03T08:52:06Z
2017-03-01
Article
Hepatitis B vaccination timing: results from demographic health surveys in 47 countries. 2017, 95 (3):199-209G Bull. World Health Organ.
1564-0604
28250533
10.2471/BLT.16.178822
http://hdl.handle.net/10033/621220
Bulletin of the World Health Organization
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212392019-08-30T11:35:39Zcom_10033_211390com_10033_620533col_10033_621891col_10033_211409
Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data.
Vital, Marius
Karch, André
Pieper, Dietmar H.
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.
Given the key role of butyrate for host health, understanding the ecology of intestinal butyrate-producing communities is a top priority for gut microbiota research. To this end, we performed a pooled analysis on 2,387 metagenomic/transcriptomic samples from 15 publicly available data sets that originated from three continents and encompassed eight diseases as well as specific interventions. For analyses, a gene catalogue was constructed from gene-targeted assemblies of all genes from butyrate synthesis pathways of all samples and from an updated reference database derived from genome screenings. We demonstrate that butyrate producers establish themselves within the first year of life and display high abundances (>20% of total bacterial community) in adults regardless of origin. Various bacteria form this functional group, exhibiting a biochemical diversity including different pathways and terminal enzymes, where one carbohydrate-fueled pathway was dominant with butyryl coenzyme A (CoA):acetate CoA transferase as the main terminal enzyme. Subjects displayed a high richness of butyrate producers, and 17 taxa, primarily members of the Lachnospiraceae and Ruminococcaceae along with some Bacteroidetes, were detected in >70% of individuals, encompassing ~85% of the total butyrate-producing potential. Most of these key taxa were also found to express genes for butyrate formation, indicating that butyrate producers occupy various niches in the gut ecosystem, concurrently synthesizing that compound. Furthermore, results from longitudinal analyses propose that diversity supports functional stability during ordinary life disturbances and during interventions such as antibiotic treatment. A reduction of the butyrate-producing potential along with community alterations was detected in various diseases, where patients suffering from cardiometabolic disorders were particularly affected. IMPORTANCE Studies focusing on taxonomic compositions of the gut microbiota are plentiful, whereas its functional capabilities are still poorly understood. Specific key functions deserve detailed investigations, as they regulate microbiota-host interactions and promote host health and disease. The production of butyrate is among the top targets since depletion of this microbe-derived metabolite is linked to several emerging noncommunicable diseases and was shown to facilitate establishment of enteric pathogens by disrupting colonization resistance. In this study, we established a workflow to investigate in detail the composition of the polyphyletic butyrate-producing community from omics data extracting its biochemical and taxonomic diversity. By combining information from various publicly available data sets, we identified universal ecological key features of this functional group and shed light on its role in health and disease. Our results will assist the development of precision medicine to combat functional dysbiosis.
2018-01-18T14:04:22Z
2018-01-18T14:04:22Z
2018-01-18
Article
Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data., 2 (6) mSystems
2379-5077
29238752
10.1128/mSystems.00130-17
http://hdl.handle.net/10033/621239
mSystems
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212552019-08-30T11:28:51Zcom_10033_267632com_10033_211390com_10033_311308col_10033_267633col_10033_211409col_10033_620721
Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity - a simulation study.
Bakuli, Abhishek
Klawonn, Frank
Karch, André
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsforschung, GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Increased computational resources have made individual based models popular for modelling epidemics. They have the advantage of incorporating heterogeneous features, including realistic population structures (like e.g. households). Existing stochastic simulation studies of epidemics, however, have been developed mainly for incorporating single pathogen scenarios although the effect of different pathogens might directly or indirectly (e.g. via contact reductions) effect the spread of each pathogen. The goal of this work was to simulate a stochastic agent based system incorporating the effect of multiple pathogens, accounting for the household based transmission process and the dependency among pathogens.
2018-01-24T15:11:28Z
2018-01-24T15:11:28Z
2017-12-13
Article
Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity - a simulation study. 2017, 14 (1):26 Theor Biol Med Model
1742-4682
29237462
10.1186/s12976-017-0072-7
http://hdl.handle.net/10033/621255
Theoretical biology & medical modelling
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212562019-08-30T11:33:57Zcom_10033_267632com_10033_211390col_10033_267633
Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models.
Brisson, Marc
Bénard, Élodie
Drolet, Mélanie
Bogaards, Johannes A
Baussano, Iacopo
Vänskä, Simopekka
Jit, Mark
Boily, Marie-Claude
Smith, Megan A
Berkhof, Johannes
Canfell, Karen
Chesson, Harrell W
Burger, Emily A
Choi, Yoon H
De Blasio, Birgitte Freiesleben
De Vlas, Sake J
Guzzetta, Giorgio
Hontelez, Jan A C
Horn, Johannes
Jepsen, Martin R
Kim, Jane J
Lazzarato, Fulvio
Matthijsse, Suzette M
Mikolajczyk, Rafael T
Pavelyev, Andrew
Pillsbury, Matthew
Shafer, Leigh Anne
Tully, Stephen P
Turner, Hugo C
Usher, Cara
Walsh, Cathal
Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Modelling studies have been widely used to inform human papillomavirus (HPV) vaccination policy decisions; however, many models exist and it is not known whether they produce consistent predictions of population-level effectiveness and herd effects. We did a systematic review and meta-analysis of model predictions of the long-term population-level effectiveness of vaccination against HPV 16, 18, 6, and 11 infection in women and men, to examine the variability in predicted herd effects, incremental benefit of vaccinating boys, and potential for HPV-vaccine-type elimination.
2018-01-29T13:52:41Z
2018-01-29T13:52:41Z
2016-11
Article
Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models. 2016, 1 (1):e8-e17 Lancet Public Health
2468-2667
29253379
10.1016/S2468-2667(16)30001-9
http://hdl.handle.net/10033/621256
The Lancet. Public health
en
'info:eu-repo/grantAgreement/EC/FP7/ 603019
openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212632019-08-30T11:36:30Zcom_10033_211390col_10033_211409
Changing infection patterns - New evidence on the prevalence of nosocomial infections and antibiotic resistance in hospitals in Germany
Krause, Gerard
Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.
Editorial to accompany the articles: „The Prevalence of Nosocomial Infection and Antibiotic Use in German Hospitals“ by Michael Behnke et al. and „Surveillance of Antibiotic Use and Resistance in Intensive Care Units (SARI)—A 15-year Cohort Study“ by Cornelius Remschmidt et al. in this issue of Deutsches Ärzteblatt International
2018-02-06T14:11:12Z
2018-02-06T14:11:12Z
2018-02-06
2018-02-06
Other
http://hdl.handle.net/10033/621263
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
Deutscher Arzte-Verlag GmbH
oai:repository.helmholtz-hzi.de:10033/6212652019-08-30T11:37:24Zcom_10033_211390col_10033_211409
Public Health Research Resulting from One of the World's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review.
Köckerling, Elena
Karrasch, Laura
Schweitzer, Aparna
Razum, Oliver
Krause, Gerard
Helmhotz Zentrum füt Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
In 2011, Germany experienced one of the largest outbreaks of entero-hemorrhagic Escherichia coli (EHEC) ever reported. Four years thereafter, we systematically searched for scientific publications in PubMed and MEDPILOT relating to this outbreak in order to assess the pattern of respective research activities and to assess the main findings and recommendations in the field of public health. Following PRISMA guidelines, we selected 133 publications, half of which were published within 17 months after outbreak onset. Clinical medicine was covered by 71, microbiology by 60, epidemiology by 46, outbreak reporting by 11, and food safety by 9 papers. Those on the last three topics drew conclusions on methods in surveillance, diagnosis, and outbreak investigation, on resources in public health, as well as on inter-agency collaboration, and public communication. Although the outbreak primarily affected Germany, most publications were conducted by multinational cooperations. Our findings document how soon and in which fields research was conducted with respect to this outbreak.
2018-02-07T09:13:12Z
2018-02-07T09:13:12Z
2017
Article
Public Health Research Resulting from One of the World's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. 2017, 5:332 Front Public Health
2296-2565
29312915
10.3389/fpubh.2017.00332
http://hdl.handle.net/10033/621265
Frontiers in public health
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai:repository.helmholtz-hzi.de:10033/6212862019-08-30T11:31:23Zcom_10033_267632com_10033_211390col_10033_267633col_10033_211409
["I cannot kiss my wife"- An Analysis of Daily Experiences of MRSA-carriers].
Raupach-Rosin, H
Klett-Tammen, C J
Schmalz, O
Karch, A
Castell, S
Mikolajczyk, Rafael T
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Activities of Daily Living
Adult
Carrier State
Female
Focus Groups
Germany
Health Services Accessibility
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Social Isolation
Staphylococcal Infections
Stereotyping
Objectives: There are no data available on the quality of care after discharge from hospital and only limited data are available on the psychosocial effects of being an MRSA carrier within the German health system.Methods:Patients who tested positive for MRSA in the previous year were invited to take part in focus groups.Results:2 focus groups with a total of 9 MRSA-carriers were conducted. The level of knowledge about MRSA differed between participants. In some cases, lack of information led to uncertainty and inappropriate measures to counteract MRSA. Some participants restricted their social contacts, especially to children, in order to prevent transmission. Patients experienced stigmatization in the health care system more often in inpatient care than in the outpatient sector. Only in a few cases both eradication therapy and swabs for control purposes were carried out.Conclusions:Information about the appropriate treatment and management of MRSA should be made available to patients more easily; in particular, patients need to be informed that MRSA is no threat to healthy individuals. Despite the desire of MRSA-carriers to become MRSA negative, treatment and control of MRSA seem to have low priority in the ambulant health care sector in Germany.
2018-02-19T15:14:45Z
2018-02-19T15:14:45Z
2016-12
Article
["I cannot kiss my wife"- An Analysis of Daily Experiences of MRSA-carriers]. 2016, 78 (12):822-827 Gesundheitswesen
1439-4421
26551853
10.1055/s-0035-1559710
http://hdl.handle.net/10033/621286
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))
ger
en
http://creativecommons.org/licenses/by-nc-sa/4.0/
oai_dc///com_10033_211390/100