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dc.contributor.authorToker, Aras
dc.contributor.authorHuehn, Jochen
dc.date.accessioned2011-04-14T09:34:46Z
dc.date.available2011-04-14T09:34:46Z
dc.date.issued2011
dc.identifier.citationTo be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. 2011, 4 (158):pe4 Sci Signalen
dc.identifier.issn1937-9145
dc.identifier.pmid21285410
dc.identifier.doi10.1126/scisignal.2001783
dc.identifier.urihttp://hdl.handle.net/10033/128113
dc.description.abstractRegulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.
dc.language.isoenen
dc.titleTo be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms.en
dc.typeArticleen
dc.contributor.departmentExperimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.en
dc.identifier.journalScience signalingen
refterms.dateFOA2018-06-13T09:18:41Z
html.description.abstractRegulatory T (T(reg)) cells are a unique CD4(+) T cell lineage that plays a crucial role in the maintenance of immunological tolerance. The Forkhead box transcription factor Foxp3 is critically involved in T(reg) cell development and responsible for determining the suppressive function of these cells. The majority of Foxp3(+) T(reg) cells are generated during T cell development within the thymus and show features of a stable T cell lineage. New work indicates that both induction and stabilization of Foxp3 expression are under epigenetic control, which suggests that selective interference with the underlying chromatin remodeling mechanisms might enable the development of future therapeutic strategies targeting T(reg) cells.


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