Biological activity of volatiles from marine and terrestrial bacteria.
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Authors
Schulz, StefanDickschat, Jeroen S
Kunze, Brigitte
Wagner-Döbler, Irene
Diestel, Randi
Sasse, Florenz
Issue Date
2010
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Show full item recordAbstract
The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.Citation
Biological activity of volatiles from marine and terrestrial bacteria. 2010, 8 (12):2976-87 Mar DrugsAffiliation
Institute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.deJournal
Marine drugsPubMed ID
21339960Type
ArticleLanguage
enISSN
1660-3397ae974a485f413a2113503eed53cd6c53
10.3390/md8122976
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