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dc.contributor.authorTsuda, Yoshimi
dc.contributor.authorCaposio, Patrizia
dc.contributor.authorParkins, Christopher J
dc.contributor.authorBotto, Sara
dc.contributor.authorMessaoudi, Ilhem
dc.contributor.authorCicin-Sain, Luka
dc.contributor.authorFeldmann, Heinz
dc.contributor.authorJarvis, Michael A
dc.date.accessioned2012-03-01T15:40:56Z
dc.date.available2012-03-01T15:40:56Z
dc.date.issued2011-08
dc.identifier.citationA replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Disen
dc.identifier.issn1935-2735
dc.identifier.pmid21858240
dc.identifier.doi10.1371/journal.pntd.0001275
dc.identifier.urihttp://hdl.handle.net/10033/213809
dc.description.abstractHuman outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshDrug Carriersen
dc.subject.meshEbola Vaccinesen
dc.subject.meshEbolavirusen
dc.subject.meshEpitopes, T-Lymphocyteen
dc.subject.meshFemaleen
dc.subject.meshGenetic Vectorsen
dc.subject.meshHemorrhagic Fever, Ebolaen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMuromegalovirusen
dc.subject.meshNucleoproteinsen
dc.subject.meshT-Lymphocytes, Cytotoxicen
dc.subject.meshVaccines, Subuniten
dc.subject.meshVaccines, Syntheticen
dc.titleA replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.en
dc.typeArticleen
dc.contributor.departmentLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.en
dc.identifier.journalPLoS neglected tropical diseasesen
refterms.dateFOA2018-06-13T07:45:15Z
html.description.abstractHuman outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.


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