Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.
dc.contributor.author | Chhatwal, Patrick | |
dc.contributor.author | Bankwitz, Dorothea | |
dc.contributor.author | Gentzsch, Juliane | |
dc.contributor.author | Frentzen, Anne | |
dc.contributor.author | Schult, Philipp | |
dc.contributor.author | Lohmann, Volker | |
dc.contributor.author | Pietschmann, Thomas | |
dc.date.accessioned | 2012-05-10T09:24:05Z | en |
dc.date.available | 2012-05-10T09:24:05Z | en |
dc.date.issued | 2012 | en |
dc.identifier.citation | Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONE | en_GB |
dc.identifier.issn | 1932-6203 | en |
dc.identifier.pmid | 22558311 | en |
dc.identifier.doi | 10.1371/journal.pone.0036029 | en |
dc.identifier.uri | http://hdl.handle.net/10033/222998 | en |
dc.description.abstract | Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to PloS one | en_GB |
dc.title | Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. | en |
dc.type | Article | en |
dc.contributor.department | Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany. | en_GB |
dc.identifier.journal | PloS one | en_GB |
refterms.dateFOA | 2018-06-13T09:15:30Z | |
html.description.abstract | Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication. |