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dc.contributor.authorChhatwal, Patrick
dc.contributor.authorBankwitz, Dorothea
dc.contributor.authorGentzsch, Juliane
dc.contributor.authorFrentzen, Anne
dc.contributor.authorSchult, Philipp
dc.contributor.authorLohmann, Volker
dc.contributor.authorPietschmann, Thomas
dc.date.accessioned2012-05-10T09:24:05Zen
dc.date.available2012-05-10T09:24:05Zen
dc.date.issued2012en
dc.identifier.citationBile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONEen_GB
dc.identifier.issn1932-6203en
dc.identifier.pmid22558311en
dc.identifier.doi10.1371/journal.pone.0036029en
dc.identifier.urihttp://hdl.handle.net/10033/222998en
dc.description.abstractHepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.titleBile Acids Specifically Increase Hepatitis C Virus RNA-Replication.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.en_GB
dc.identifier.journalPloS oneen_GB
refterms.dateFOA2018-06-13T09:15:30Z
html.description.abstractHepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.


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