Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypes.
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Authors
Gobert, Alain PCoste, Alix
Guzman, Carlos A
Vareille, Marjolaine
Hindré, Thomas
de Sablet, Thibaut
Girardeau, Jean-Pierre
Martin, Christine
Issue Date
2008-02
Metadata
Show full item recordAbstract
Infection with Shiga-toxin producing Escherichia coli (STEC) may result in the development of the haemolytic-uremic syndrome (HUS), the main cause of acute renal failure in children. While O157:H7 STEC are associated with large outbreaks of HUS, it is difficult to predict whether a non-O157:H7 isolate can be pathogenic for humans. The mucosal innate immune response plays a central role in the pathogenesis of HUS; therefore, we compared the induction of IL-8 and CCL20 in human colon epithelial cells infected with strains belonging to different serotypes, isolated from cattle or from HUS patients. No correlation was observed between strain virulence and chemokine gene expression. Rather, the genetic background of the strains seems to determine the chemokine gene expression profile. Investigating the contribution of different bacterial factors in this process, we show that the type III secretion system of O157:H7 bacteria, but not the intimate adhesion, is required to stimulate the cells. In addition, H7, H10, and H21 flagellins are potent inducers of chemokine gene expression when synthesized in large amount.Citation
Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypes. 2008, 10 (2):159-65 Microbes Infect.Affiliation
Institut National de la Recherche Agronomique (INRA), UR454 Unité de Microbiologie, Centre de Theix, 63122 Saint-Genès-Champanelle, France.PubMed ID
18248761Type
ArticleLanguage
enISSN
1286-4579ae974a485f413a2113503eed53cd6c53
10.1016/j.micinf.2007.10.018
Scopus Count
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