Show simple item record

dc.contributor.authorHaggar, Axana
dc.contributor.authorNerlich, Andreas
dc.contributor.authorKumar, Rajesh
dc.contributor.authorAbraham, Vinod J
dc.contributor.authorBrahmadathan, Kootallur N
dc.contributor.authorRay, Pallab
dc.contributor.authorDhanda, Vanita
dc.contributor.authorJoshua, John Melbin Jose
dc.contributor.authorMehra, Narinder
dc.contributor.authorBergmann, Rene
dc.contributor.authorChhatwal, G Singh
dc.contributor.authorNorrby-Teglund, Anna
dc.date.accessioned2012-09-17T14:05:47Z
dc.date.available2012-09-17T14:05:47Z
dc.date.issued2012-05
dc.identifier.citationClinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India. 2012, 50 (5):1626-31 J. Clin. Microbiol.en_GB
dc.identifier.issn1098-660X
dc.identifier.pmid22357508
dc.identifier.doi10.1128/JCM.06697-11
dc.identifier.urihttp://hdl.handle.net/10033/244332
dc.description.abstractThe lack of epidemiologic data on invasive Streptococcus pyogenes infections in many developing countries is concerning, as S. pyogenes infections are commonly endemic in these areas. Here we present the results of the first prospective surveillance study of invasive Streptococcus pyogenes infections in India. Fifty-four patients with invasive S. pyogenes infections were prospectively enrolled at two study sites, one in the north and one in the south of India. Sterile-site isolates were collected, and clinical information was documented using a standardized questionnaire. Available acute-phase sera were tested for their ability to inhibit superantigens produced by the patient's own isolate using a cell-based neutralizing assay. The most common clinical presentations were bacteremia without focus (30%), pneumonia (28%), and cellulitis (17%). Only two cases of streptococcal toxic shock syndrome and no cases of necrotizing fasciitis were identified. Characterization of the isolates revealed great heterogeneity, with 32 different emm subtypes and 29 different superantigen gene profiles being represented among the 49 sterile-site isolates. Analyses of acute-phase sera showed that only 20% of the cases in the north cohort had superantigen-neutralizing activity in their sera, whereas 50% of the cases from the south site had neutralizing activity. The results demonstrate that there are important differences in both clinical presentation and strain characteristics between invasive S. pyogenes infections in India and invasive S. pyogenes infections in Western countries. The findings underscore the importance of epidemiologic studies on streptococcal infections in India and have direct implications for current vaccine developments.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of clinical microbiologyen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAntibodies, Bacterialen_GB
dc.subject.meshAntibodies, Neutralizingen_GB
dc.subject.meshChilden_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIndiaen_GB
dc.subject.meshInfanten_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMolecular Epidemiologyen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshSerotypingen_GB
dc.subject.meshStreptococcal Infectionsen_GB
dc.subject.meshStreptococcus pyogenesen_GB
dc.subject.meshSuperantigensen_GB
dc.subject.meshYoung Adulten_GB
dc.titleClinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India.en
dc.typeArticleen
dc.contributor.departmentCenter for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.en_GB
dc.identifier.journalJournal of clinical microbiologyen_GB
refterms.dateFOA2018-06-12T16:43:42Z
html.description.abstractThe lack of epidemiologic data on invasive Streptococcus pyogenes infections in many developing countries is concerning, as S. pyogenes infections are commonly endemic in these areas. Here we present the results of the first prospective surveillance study of invasive Streptococcus pyogenes infections in India. Fifty-four patients with invasive S. pyogenes infections were prospectively enrolled at two study sites, one in the north and one in the south of India. Sterile-site isolates were collected, and clinical information was documented using a standardized questionnaire. Available acute-phase sera were tested for their ability to inhibit superantigens produced by the patient's own isolate using a cell-based neutralizing assay. The most common clinical presentations were bacteremia without focus (30%), pneumonia (28%), and cellulitis (17%). Only two cases of streptococcal toxic shock syndrome and no cases of necrotizing fasciitis were identified. Characterization of the isolates revealed great heterogeneity, with 32 different emm subtypes and 29 different superantigen gene profiles being represented among the 49 sterile-site isolates. Analyses of acute-phase sera showed that only 20% of the cases in the north cohort had superantigen-neutralizing activity in their sera, whereas 50% of the cases from the south site had neutralizing activity. The results demonstrate that there are important differences in both clinical presentation and strain characteristics between invasive S. pyogenes infections in India and invasive S. pyogenes infections in Western countries. The findings underscore the importance of epidemiologic studies on streptococcal infections in India and have direct implications for current vaccine developments.


Files in this item

Thumbnail
Name:
Haggar et al_final.pdf
Size:
270.2Kb
Format:
PDF
Description:
original manuscript
Thumbnail
Name:
figure 1.tif
Size:
475.7Kb
Format:
TIFF image
Description:
figure 1
Thumbnail
Name:
figure 2.tif
Size:
4.001Mb
Format:
TIFF image
Description:
figure 2
Thumbnail
Name:
figure 3.tif
Size:
2.585Mb
Format:
TIFF image
Description:
figure 3
Thumbnail
Name:
Table S1.pdf
Size:
15.96Kb
Format:
PDF
Description:
supplemental table 1

This item appears in the following Collection(s)

Show simple item record