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dc.contributor.authorMueller, Peter P
dc.contributor.authorArnold, Sylvia
dc.contributor.authorBadar, Muhammad
dc.contributor.authorBormann, Dirk
dc.contributor.authorBach, Friedrich-Wilhelm
dc.contributor.authorDrynda, Andreas
dc.contributor.authorMeyer-Lindenberg, Andrea
dc.contributor.authorHauser, Hansjörg
dc.contributor.authorPeuster, Matthias
dc.date.accessioned2013-01-28T15:17:07Z
dc.date.available2013-01-28T15:17:07Z
dc.date.issued2012-11
dc.identifier.citationHistological and molecular evaluation of iron as degradable medical implant material in a murine animal model. 2012, 100 (11):2881-9 J Biomed Mater Res Aen_GB
dc.identifier.issn1552-4965
dc.identifier.pmid22623368
dc.identifier.doi10.1002/jbm.a.34223
dc.identifier.urihttp://hdl.handle.net/10033/267332
dc.description.abstractA small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of biomedical materials research. Part Aen_GB
dc.titleHistological and molecular evaluation of iron as degradable medical implant material in a murine animal model.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection Research, Braunschweig, Germany. pmu@gbf.deen_GB
dc.identifier.journalJournal of biomedical materials research. Part Aen_GB
refterms.dateFOA2013-11-15T00:00:00Z
html.description.abstractA small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body.


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