Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
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Zahid, Muhammad Nauman
Foung, Steven K H
Zeisel, Mirjam B
Baumert, Thomas F
MetadataShow full item record
AbstractThe development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune responses is poorly understood. We used acute infection of liver graft as a model to investigate the molecular mechanisms of viral evasion.
CitationMutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. 2012, 143 (1):223-233.e9 Gastroenterology
AffiliationInserm, U748, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
The following license files are associated with this item:
- Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies.
- Authors: Fauvelle C, Felmlee DJ, Crouchet E, Lee J, Heydmann L, Lefèvre M, Magri A, Hiet MS, Fofana I, Habersetzer F, Foung SK, Milne R, Patel AH, Vercauteren K, Meuleman P, Zeisel MB, Bartenschlager R, Schuster C, Baumert TF
- Issue date: 2016 Jan
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- A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission.
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- Neutralizing antibodies and pathogenesis of hepatitis C virus infection.
- Authors: Fafi-Kremer S, Fauvelle C, Felmlee DJ, Zeisel MB, Lepiller Q, Fofana I, Heydmann L, Stoll-Keller F, Baumert TF
- Issue date: 2012 Oct 9