Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
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Authors
Fofana, IsabelFafi-Kremer, Samira
Carolla, Patric
Fauvelle, Catherine
Zahid, Muhammad Nauman
Turek, Marine
Heydmann, Laura
Cury, Karine
Hayer, Juliette
Combet, Christophe
Cosset, François-Loïc
Pietschmann, Thomas
Hiet, Marie-Sophie
Bartenschlager, Ralf
Habersetzer, François
Doffoël, Michel
Keck, Zhen-Yong
Foung, Steven K H
Zeisel, Mirjam B
Stoll-Keller, Françoise
Baumert, Thomas F
Issue Date
2012-07
Metadata
Show full item recordAbstract
The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune responses is poorly understood. We used acute infection of liver graft as a model to investigate the molecular mechanisms of viral evasion.Citation
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. 2012, 143 (1):223-233.e9 GastroenterologyAffiliation
Inserm, U748, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.Journal
GastroenterologyPubMed ID
22503792Type
ArticleLanguage
enISSN
1528-0012ae974a485f413a2113503eed53cd6c53
10.1053/j.gastro.2012.04.006
Scopus Count
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