Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.
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Authors
Nedelko, TatianaKollmus, Heike
Klawonn, Frank
Spijker, Sabine
Lu, Lu
Heßman, Manuela
Alberts, Rudi
Williams, Robert W
Schughart, Klaus
Issue Date
2012
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Show full item recordAbstract
There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease progression. In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible.Citation
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. 2012, 13:411 BMC GenomicsAffiliation
Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany.Journal
BMC genomicsPubMed ID
22905720Type
ArticleLanguage
enISSN
1471-2164ae974a485f413a2113503eed53cd6c53
10.1186/1471-2164-13-411
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