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dc.contributor.authorHasenberg, Mike
dc.contributor.authorStegemann-Koniszewski, Sabine
dc.contributor.authorGunzer, Matthias
dc.date.accessioned2013-04-15T14:10:55Z
dc.date.available2013-04-15T14:10:55Z
dc.date.issued2013-01
dc.identifier.citationCellular immune reactions in the lung. 2013, 251 (1):189-214 Immunol. Rev.en_GB
dc.identifier.issn1600-065X
dc.identifier.pmid23278750
dc.identifier.doi10.1111/imr.12020
dc.identifier.urihttp://hdl.handle.net/10033/281353
dc.description.abstractThe lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions.
dc.language.isoenen
dc.rightsArchived with thanks to Immunological reviewsen_GB
dc.titleCellular immune reactions in the lung.en
dc.typeArticleen
dc.contributor.departmentInstitute of Experimental Immunology and Imaging, University of Duisburg/Essen, University Hospital, Essen, Germany.en_GB
dc.identifier.journalImmunological reviewsen_GB
refterms.dateFOA2014-01-15T00:00:00Z
html.description.abstractThe lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions.


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