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dc.contributor.authorScopel, Marina
dc.contributor.authorAbraham, Wolf-Rainer
dc.contributor.authorHenriques, Amélia T
dc.contributor.authorMacedo, Alexandre J
dc.date.accessioned2013-06-24T11:31:04Z
dc.date.available2013-06-24T11:31:04Z
dc.date.issued2013-02-01
dc.identifier.citationDipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis. 2013, 23 (3):624-6 Bioorg. Med. Chem. Lett.en_GB
dc.identifier.issn1464-3405
dc.identifier.pmid23290053
dc.identifier.doi10.1016/j.bmcl.2012.12.020
dc.identifier.urihttp://hdl.handle.net/10033/294441
dc.description.abstractInfections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides.
dc.language.isoenen
dc.rightsArchived with thanks to Bioorganic & medicinal chemistry lettersen_GB
dc.titleDipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis.en
dc.typeArticleen
dc.contributor.departmentFaculdade de Farmácia, Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000 Porto Alegre, Brazil.en_GB
dc.identifier.journalBioorganic & medicinal chemistry lettersen_GB
refterms.dateFOA2018-06-12T23:30:15Z
html.description.abstractInfections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides.


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