The formation of an organic coat and the release of corrosion microparticles from metallic magnesium implants.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Rahim, Muhammad Imran
Mueller, Peter P
MetadataShow full item record
AbstractMagnesium alloys have been proposed as prospective degradable implant materials. To elucidate the complex interactions between the corroding implants and the tissue, magnesium implants were analyzed in a mouse model and the response was compared to that induced by Ti and by the resorbable polymer polyglactin, respectively. One month after implantation, distinct traces of corrosion were apparent but the magnesium implants were still intact, whereas resorbable polymeric wound suture implants were already fragmented. Analysis of magnesium implants 2weeks after implantation by energy-dispersive X-ray spectroscopy indicated that magnesium, oxygen, calcium and phosphate were present at the implant surface. One month after implantation, the element composition of the outermost layer of the implant was indicative of tissue without detectable levels of magnesium, indicating a protective barrier function of this organic layer. In agreement with this notion, gene expression patterns in the surrounding tissue were highly similar for all implant materials investigated. However, high-resolution imaging using energy-filtered transmission electron microscopy revealed magnesium-containing microparticles in the tissue in the proximity of the implant. The release of such corrosion particles may contribute to the accumulation of calcium phosphate in the nearby tissue and to bone conductive activities of magnesium implants.
CitationThe formation of an organic coat and the release of corrosion microparticles from metallic magnesium implants. 2013, 9 (7):7580-9 Acta Biomater
AffiliationHelmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- In vivo corrosion of four magnesium alloys and the associated bone response.
- Authors: Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, Windhagen H
- Issue date: 2005 Jun
- In vitro and in vivo corrosion measurements of magnesium alloys.
- Authors: Witte F, Fischer J, Nellesen J, Crostack HA, Kaese V, Pisch A, Beckmann F, Windhagen H
- Issue date: 2006 Mar
- Phosphate conversion coating reduces the degradation rate and suppresses side effects of metallic magnesium implants in an animal model.
- Authors: Rahim MI, Tavares A, Evertz F, Kieke M, Seitz JM, Eifler R, Weizbauer A, Willbold E, Jürgen Maier H, Glasmacher B, Behrens P, Hauser H, Mueller PP
- Issue date: 2017 Aug
- Differential magnesium implant corrosion coat formation and contribution to bone bonding.
- Authors: Rahim MI, Weizbauer A, Evertz F, Hoffmann A, Rohde M, Glasmacher B, Windhagen H, Gross G, Seitz JM, Mueller PP
- Issue date: 2017 Mar
- In vivo corrosion behavior of Mg-Mn-Zn alloy for bone implant application.
- Authors: Xu L, Yu G, Zhang E, Pan F, Yang K
- Issue date: 2007 Dec 1