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dc.contributor.authorAltendorfer, Mario
dc.contributor.authorRaja, Aruna
dc.contributor.authorSasse, Florenz
dc.contributor.authorIrschik, Herbert
dc.contributor.authorMenche, Dirk
dc.date.accessioned2013-10-02T08:38:32Z
dc.date.available2013-10-02T08:38:32Z
dc.date.issued2013-04-07
dc.identifier.citationModular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes. 2013, 11 (13):2116-39 Org. Biomol. Chem.en
dc.identifier.issn1477-0539
dc.identifier.pmid23196931
dc.identifier.doi10.1039/c2ob26906f
dc.identifier.urihttp://hdl.handle.net/10033/302604
dc.description.abstractAn efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.
dc.language.isoenen
dc.rightsArchived with thanks to Organic & biomolecular chemistryen
dc.titleModular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.en
dc.typeArticleen
dc.contributor.departmentUniversity of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany, EU.en
dc.identifier.journalOrganic & biomolecular chemistryen
refterms.dateFOA2014-04-15T00:00:00Z
html.description.abstractAn efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.


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