Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.
dc.contributor.author | Altendorfer, Mario | |
dc.contributor.author | Raja, Aruna | |
dc.contributor.author | Sasse, Florenz | |
dc.contributor.author | Irschik, Herbert | |
dc.contributor.author | Menche, Dirk | |
dc.date.accessioned | 2013-10-02T08:38:32Z | |
dc.date.available | 2013-10-02T08:38:32Z | |
dc.date.issued | 2013-04-07 | |
dc.identifier.citation | Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes. 2013, 11 (13):2116-39 Org. Biomol. Chem. | en |
dc.identifier.issn | 1477-0539 | |
dc.identifier.pmid | 23196931 | |
dc.identifier.doi | 10.1039/c2ob26906f | |
dc.identifier.uri | http://hdl.handle.net/10033/302604 | |
dc.description.abstract | An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Organic & biomolecular chemistry | en |
dc.title | Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes. | en |
dc.type | Article | en |
dc.contributor.department | University of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany, EU. | en |
dc.identifier.journal | Organic & biomolecular chemistry | en |
refterms.dateFOA | 2014-04-15T00:00:00Z | |
html.description.abstract | An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. |