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dc.contributor.authorGrenningloh, R
dc.contributor.authorDarj, A
dc.contributor.authorBauer, H
dc.contributor.authorzur Lage, S
dc.contributor.authorChakraborty, T
dc.contributor.authorJacobs, T
dc.contributor.authorWeiss, S
dc.date.accessioned2008-06-23T13:21:39Z
dc.date.available2008-06-23T13:21:39Z
dc.date.issued2008-06
dc.identifier.citationLiposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol.en
dc.identifier.issn1365-3083
dc.identifier.pmid18433404
dc.identifier.doi10.1111/j.1365-3083.2008.02112.x
dc.identifier.urihttp://hdl.handle.net/10033/30322
dc.description.abstractProtection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.
dc.language.isoenen
dc.titleLiposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.en
dc.typeArticleen
dc.contributor.departmentMolecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalScandinavian journal of immunologyen
refterms.dateFOA2009-06-05T00:00:00Z
html.description.abstractProtection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.


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