Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells.
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Issue Date
2013
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The repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor- and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering.Citation
Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells. 2013, 80 (4):203-10 PathobiologyAffiliation
Department of Molecular Biotechnology, Signalling and Gene Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.PubMed ID
23652284Type
ArticleLanguage
enISSN
1423-0291ae974a485f413a2113503eed53cd6c53
10.1159/000347059
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