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dc.contributor.authorGross, Gerhard
dc.contributor.authorHoffmann, Andrea
dc.date.accessioned2013-10-31T10:36:45Z
dc.date.available2013-10-31T10:36:45Z
dc.date.issued2013
dc.identifier.citationTherapeutic strategies for tendon healing based on novel biomaterials, factors and cells. 2013, 80 (4):203-10 Pathobiologyen
dc.identifier.issn1423-0291
dc.identifier.pmid23652284
dc.identifier.doi10.1159/000347059
dc.identifier.urihttp://hdl.handle.net/10033/304838
dc.description.abstractThe repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor- and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering.
dc.language.isoenen
dc.rightsArchived with thanks to Pathobiology : journal of immunopathology, molecular and cellular biologyen
dc.titleTherapeutic strategies for tendon healing based on novel biomaterials, factors and cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Biotechnology, Signalling and Gene Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalPathobiology : journal of immunopathology, molecular and cellular biologyen
refterms.dateFOA2018-06-12T23:31:26Z
html.description.abstractThe repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor- and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering.


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