Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.
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Authors
Nandakumar, RamyaFinsterbusch, Katja
Lipps, Christoph
Neumann, Berit
Grashoff, Martina
Nair, Sharmila
Hochnadel, Inga
Lienenklaus, Stefan
Wappler, Ilka
Steinmann, Eike
Hauser, Hansjörg
Pietschmann, Thomas
Kröger, Andrea
Issue Date
2013-12
Metadata
Show full item recordAbstract
Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50% of patients control HCV infection after treatment, but the broad range of patients' outcomes and responses to treatment, among all genotypes, indicates a role for host factors. Although the IFN system is important in limiting HCV replication, the virus has evolved mechanisms to circumvent the IFN response. However, direct, IFN-independent antiviral processes also might help control HCV replication. We examined the role of IFN-independent responses against HCV replication.Citation
Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms. 2013, 145 (6):1414-23.e1 GastroenterologyAffiliation
Helmholtz Centre for infection research, D38124 Braunschweig, GermanyJournal
GastroenterologyPubMed ID
23973921Type
ArticleLanguage
enISSN
1528-0012ae974a485f413a2113503eed53cd6c53
10.1053/j.gastro.2013.08.037
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