• Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.

      Vogel, Katrin; Pierau, Mandy; Arra, Aditya; Lampe, Karen; Schlueter, Dirk; Arens, Christoph; Brunner-Weinzierl, Monika C; HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. (Nature publishing group, 2018-11-15)
      The origin of human T-cell responses against fungal pathogens early in life is not clearly understood. Here, we show that antifungal T-cell responses are vigorously initiated within the first years of life against lysates and peptides of Candida albicans or Aspergillus fumigatus, presented by autologous monocytes. The neonatal responding T-cell pool consists of 20 different TCR-V