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dc.contributor.authorJoshi, Rajendra
dc.contributor.authorFeldmann, Verena
dc.contributor.authorKoestner, Wolfgang
dc.contributor.authorDetje, Claudia
dc.contributor.authorGottschalk, Sven
dc.contributor.authorMayer, Hermann A
dc.contributor.authorSauer, Martin G
dc.contributor.authorEngelmann, Jörn
dc.date.accessioned2014-05-13T14:56:54Z
dc.date.available2014-05-13T14:56:54Z
dc.date.issued2013-01
dc.identifier.citationMultifunctional silica nanoparticles for optical and magnetic resonance imaging. 2013, 394 (1):125-35 Biol. Chem.en
dc.identifier.issn1437-4315
dc.identifier.pmid23096570
dc.identifier.doi10.1515/hsz-2012-0251
dc.identifier.urihttp://hdl.handle.net/10033/316742
dc.description.abstractThe surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.
dc.language.isoenen
dc.rightsArchived with thanks to Biological chemistryen
dc.titleMultifunctional silica nanoparticles for optical and magnetic resonance imaging.en
dc.typeArticleen
dc.contributor.departmentInstitute for Experimental Infection Research, TWINCORE , Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Straβe 7, D-30625 Hannover, Germanyen
dc.identifier.journalBiological chemistryen
refterms.dateFOA2018-06-13T03:41:07Z
html.description.abstractThe surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.


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