New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
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Issue Date
2014-07
Metadata
Show full item recordAbstract
CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.Citation
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother.PubMed ID
24820077Type
ArticleLanguage
enISSN
1098-6596ae974a485f413a2113503eed53cd6c53
10.1128/AAC.02600-14
Scopus Count
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