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dc.contributor.authorSommer, Roman
dc.contributor.authorJoachim, Ines
dc.contributor.authorWagner, Stefanie
dc.contributor.authorTitz, Alexander
dc.date.accessioned2014-12-05T09:59:07Z
dc.date.available2014-12-05T09:59:07Z
dc.date.issued2013
dc.identifier.citationNew approaches to control infections: anti-biofilm strategies against gram-negative bacteria. 2013, 67 (4):286-90 Chimia (Aarau)en
dc.identifier.issn0009-4293
dc.identifier.pmid23967708
dc.identifier.urihttp://hdl.handle.net/10033/336700
dc.description.abstractHospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.
dc.language.isoenen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBiofilmsen
dc.subject.meshCross Infectionen
dc.subject.meshGram-Negative Bacteriaen
dc.subject.meshGram-Negative Bacterial Infectionsen
dc.subject.meshHumansen
dc.titleNew approaches to control infections: anti-biofilm strategies against gram-negative bacteria.en
dc.typeArticleen
dc.contributor.departmentUniversity of Konstanz, Department of Chemistry and Zukunftskolleg, Universitätsstrasse 10, D-78457 Konstanz.en
dc.identifier.journalChimiaen
refterms.dateFOA2018-06-13T21:23:47Z
html.description.abstractHospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.


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