Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Mohr, Kathrin I
Brock, Nelson L
Dickschat, Jeroen S
MetadataShow full item record
AbstractA 3-decalinoyltetramic acid, for which the trivial name hymenosetin is proposed, was isolated from crude extracts of a virulent strain of the ash dieback pathogen, Hymenoscyphus pseudoalbidus (="Chalara fraxinea"). This compound was produced only under certain culture conditions in submerged cultures of the fungus. Its planar structure was determined by NMR spectroscopy and by mass spectrometry. The absolute stereochemistry was assigned by CD spectroscopy and HETLOC data. Hymenosetin exhibited broad spectrum antibacterial and antifungal activities (including strong inhibition of MRSA), as well as moderate cytotoxic effects. So far, the metabolite proved inactive in assays for evaluation of phytotoxicity, whereas viridiol, another secondary metabolite known from H. pseudoalbidus, was regarded as phytotoxic principle of the pathogen against its host, Fraxinus excelsior. Further studies will show whether hymenosetin constitutes a defence metabolite that is produced by the pathogenic fungus to combat other microbes and fungi in the natural environment.
CitationHymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus. 2014, 100:86-91 Phytochemistry
AffiliationHelmholtz Centre for ifection research, Innhoffenstr. 7, D38124 Braunschweig, Germany.
The following license files are associated with this item:
- Hymenoscyphus pseudoalbidus, the causal agent of European ash dieback.
- Authors: Gross A, Holdenrieder O, Pautasso M, Queloz V, Sieber TN
- Issue date: 2014 Jan
- Genotypes of Fraxinus excelsior with different susceptibility to the ash dieback pathogen Hymenoscyphus pseudoalbidus and their response to the phytotoxin viridiol - a metabolomic and microscopic study.
- Authors: Cleary MR, Andersson PF, Broberg A, Elfstrand M, Daniel G, Stenlid J
- Issue date: 2014 Jun
- Four new tetramic acid and one new furanone derivatives from the plant endophytic fungus Neopestalotiopsis sp.
- Authors: Zhao S, Chen S, Wang B, Niu S, Wu W, Guo L, Che Y
- Issue date: 2015 Jun
- A volatile lactone of Hymenoscyphus pseudoalbidus, pathogen of European ash dieback, inhibits host germination.
- Authors: Citron CA, Junker C, Schulz B, Dickschat JS
- Issue date: 2014 Apr 22
- Reproductive mode and life cycle of the ash dieback pathogen Hymenoscyphus pseudoalbidus.
- Authors: Gross A, Zaffarano PL, Duo A, Grünig CR
- Issue date: 2012 Dec