Concise review: cell therapies for hereditary metabolic liver diseases-concepts, clinical results, and future developments.
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Issue Date
2015-04
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Show full item recordAbstract
The concept of cell-based therapies for inherited metabolic liver diseases has been introduced for now more than 40 years in animal experiments, but controlled clinical data in humans are still not available. In the era of dynamic developments in stem cell science, the "right" cell for transplantation is considered as an important key for successful treatment. Do we aim to transplant mature hepatocytes or do we consider the liver as a stem/progenitor-driven organ and replenish the diseased liver with genetically normal stem/progenitor cells? Although conflicting results from cell tracing and transplantation experiments have recently emerged about the existence and role of stem/progenitor cells in the liver, their overall contribution to parenchymal cell homeostasis and tissue repair is limited. Accordingly, engraftment and repopulation efficacies of extrahepatic and liver-derived stem/progenitor cell types are considered to be lower compared to mature hepatocytes. On the basis of these results, we will discuss the current clinical cell transplantation programs for inherited metabolic liver diseases and future developments in liver cell therapy. Stem Cells 2015;33:1055-1062.Citation
Concise review: cell therapies for hereditary metabolic liver diseases-concepts, clinical results, and future developments. 2015, 33 (4):1055-62 Stem CellsAffiliation
TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.Journal
Stem cells (Dayton, Ohio)PubMed ID
25524146Type
ArticleLanguage
enISSN
1549-4918ae974a485f413a2113503eed53cd6c53
10.1002/stem.1920
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