Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Bröker, Barbara M
MetadataShow full item record
AbstractAlthough Staphylococcus aureus is a prominent cause of infections, no vaccine is currently available. Active vaccination relies on immune memory, a core competence of the adaptive immune system. To elucidate whether adaptive immunity can provide protection from serious complications of S. aureus infection, a prospective observational study of 44 patients with S. aureus infection complicated by bacteremia was conducted. At diagnosis, serum IgG binding to S. aureus extracellular proteins was quantified on immunoblots and with Luminex-based FLEXMAP 3D™ assays comprising 64 recombinant S. aureus proteins. Results were correlated with the course of the infection with sepsis as the main outcome variable. S. aureus-specific serum IgG levels at diagnosis of S. aureus infection were lower in patients developing sepsis than in patients without sepsis (P<0.05). The pattern of IgG binding to eight selected S. aureus proteins correctly predicted the disease course in 75% of patients. Robust immune memory of S. aureus was associated with protection from serious complications of bacterial invasion. Serum IgG binding to eight conserved S. aureus proteins enabled stratification of patients with high and low risk of sepsis early in the course of S. aureus infections complicated by bacteremia.
CitationSpecific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression. 2015, 128:1-7 J Proteomics
AffiliationHelmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
JournalJournal of proteomics
The following license files are associated with this item:
- Characterization of the humoral immune response during Staphylococcus aureus bacteremia and global gene expression by Staphylococcus aureus in human blood.
- Authors: den Reijer PM, Lemmens-den Toom N, Kant S, Snijders SV, Boelens H, Tavakol M, Verkaik NJ, van Belkum A, Verbrugh HA, van Wamel WJ
- Issue date: 2013
- A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis.
- Authors: Nishitani K, Beck CA, Rosenberg AF, Kates SL, Schwarz EM, Daiss JL
- Issue date: 2015 Sep
- Lower antibody levels to Staphylococcus aureus exotoxins are associated with sepsis in hospitalized adults with invasive S. aureus infections.
- Authors: Adhikari RP, Ajao AO, Aman MJ, Karauzum H, Sarwar J, Lydecker AD, Johnson JK, Nguyen C, Chen WH, Roghmann MC
- Issue date: 2012 Sep 15
- Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection.
- Authors: McNicholas S, Talento AF, O'Gorman J, Hannan MM, Lynch M, Greene CM, Humphreys H, Fitzgerald-Hughes D
- Issue date: 2014 Nov 15
- [Epidemiology, course and prognosis of Staphylococcus aureus bacteremia--Preliminary results from the INSTINCT (INvasive STaphylococcus aureus INfection CohorT) cohort].
- Authors: Seifert H, Wisplinghoff H, Kaasch A, Achilles K, Langhorst A, Peyerl-Hoffmann G, Woehrmann A, Fätkenheuer G, Salzberger B, Kern WV
- Issue date: 2008 Feb