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dc.contributor.authorSchmitz, Ingoen
dc.date.accessioned2015-08-21T08:45:23Zen
dc.date.available2015-08-21T08:45:23Zen
dc.date.issued2013en
dc.identifier.citationGadd45 proteins in immunity. 2013, 793:51-68 Adv. Exp. Med. Biol.en
dc.identifier.issn0065-2598en
dc.identifier.pmid24104473en
dc.identifier.doi10.1007/978-1-4614-8289-5_4en
dc.identifier.urihttp://hdl.handle.net/10033/575418en
dc.description.abstractThe vertebrate immune system protects the host against invading pathogens such as viruses, bacteria and parasites. It consists of an innate branch and an adaptive branch that provide immediate and long-lasting protection, respectively. As the immune system is composed of different cell types and distributed throughout the whole body, immune cells need to communicate with each other. Intercellular communication in the immune system is mediated by cytokines, which bind to specific receptors on the cell surface and activate intracellular signalling networks. Growth arrest and DNA damage-inducible 45 (Gadd45) proteins are important components of these intracellular signalling networks. They are induced by a number of cytokines and by bacterial lipopolysaccharide. Within the innate immune system, Gadd45 proteins are crucial for the differentiation of myeloid cells as well as for the function of granulocytes and macrophages. Moreover, Gadd45β regulates autophagy, a catabolic pathway that also degrades intracellular pathogens. Regarding adaptive immunity, Gadd45 proteins are especially well characterized in T cells. For instance, Gadd45β and Gadd45γ regulate cytokine expression and Th1 differentiation, while Gadd45α inhibits p38 kinase activation downstream of the T cell receptor. Due to their many functions in the immune system, deficiency in Gadd45 proteins causes autoimmune diseases and less efficient tumour immunosurveillance.
dc.language.isoenen
dc.subject.meshAdaptive Immunityen
dc.subject.meshAnimalsen
dc.subject.meshAntigens, Differentiationen
dc.subject.meshAutophagyen
dc.subject.meshCell Communicationen
dc.subject.meshCell Cycle Proteinsen
dc.subject.meshCytokinesen
dc.subject.meshGene Expression Regulationen
dc.subject.meshHumansen
dc.subject.meshImmunity, Innateen
dc.subject.meshIntracellular Signaling Peptides and Proteinsen
dc.subject.meshMacrophagesen
dc.subject.meshMyeloid Cellsen
dc.subject.meshNuclear Proteinsen
dc.subject.meshPolysaccharidesen
dc.subject.meshSignal Transductionen
dc.subject.meshT-Lymphocytesen
dc.titleGadd45 proteins in immunity.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalAdvances in experimental medicine and biologyen
refterms.dateFOA2018-06-13T04:06:20Z
html.description.abstractThe vertebrate immune system protects the host against invading pathogens such as viruses, bacteria and parasites. It consists of an innate branch and an adaptive branch that provide immediate and long-lasting protection, respectively. As the immune system is composed of different cell types and distributed throughout the whole body, immune cells need to communicate with each other. Intercellular communication in the immune system is mediated by cytokines, which bind to specific receptors on the cell surface and activate intracellular signalling networks. Growth arrest and DNA damage-inducible 45 (Gadd45) proteins are important components of these intracellular signalling networks. They are induced by a number of cytokines and by bacterial lipopolysaccharide. Within the innate immune system, Gadd45 proteins are crucial for the differentiation of myeloid cells as well as for the function of granulocytes and macrophages. Moreover, Gadd45β regulates autophagy, a catabolic pathway that also degrades intracellular pathogens. Regarding adaptive immunity, Gadd45 proteins are especially well characterized in T cells. For instance, Gadd45β and Gadd45γ regulate cytokine expression and Th1 differentiation, while Gadd45α inhibits p38 kinase activation downstream of the T cell receptor. Due to their many functions in the immune system, deficiency in Gadd45 proteins causes autoimmune diseases and less efficient tumour immunosurveillance.


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