Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.
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AuthorsMarandu, Thomas F
Oduro, Jennifer D
Uhrlaub, Jennifer L
MetadataShow full item record
AbstractLatent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.
CitationImmune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections. 2015, 89 (22):11715-7 J. Virol.
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
JournalJournal of virology
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