Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Brunkhorst, Frank M
Mikolajczyk, Rafael T
MetadataShow full item record
AbstractEarly and appropriate blood culture sampling is recommended as a standard of care for patients with suspected bloodstream infections (BSI) but is rarely taken into account when quality indicators for BSI are evaluated. To date, sampling of about 100 to 200 blood culture sets per 1,000 patient-days is recommended as the target range for blood culture rates. However, the empirical basis of this recommendation is not clear. The aim of the current study was to analyze the association between blood culture rates and observed BSI rates and to derive a reference threshold for blood culture rates in intensive care units (ICUs). This study is based on data from 223 ICUs taking part in the German hospital infection surveillance system. We applied locally weighted regression and segmented Poisson regression to assess the association between blood culture rates and BSI rates. Below 80 to 90 blood culture sets per 1,000 patient-days, observed BSI rates increased with increasing blood culture rates, while there was no further increase above this threshold. Segmented Poisson regression located the threshold at 87 (95% confidence interval, 54 to 120) blood culture sets per 1,000 patient-days. Only one-third of the investigated ICUs displayed blood culture rates above this threshold. We provided empirical justification for a blood culture target threshold in ICUs. In the majority of the studied ICUs, blood culture sampling rates were below this threshold. This suggests that a substantial fraction of BSI cases might remain undetected; reporting observed BSI rates as a quality indicator without sufficiently high blood culture rates might be misleading.
CitationProposing an empirically justified reference threshold for blood culture sampling rates in intensive care units. 2015, 53 (2):648-52 J. Clin. Microbiol.
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
JournalJournal of clinical microbiology
The following license files are associated with this item:
- [Assessment of diagnostic methods for the catheter-related bloodstream infections in intensive care units].
- Authors: Ataman Hatipoğlu C, Ipekkan K, Oral B, Onde U, Bulut C, Demiröz AP
- Issue date: 2011 Jan
- 'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England.
- Authors: Bion J, Richardson A, Hibbert P, Beer J, Abrusci T, McCutcheon M, Cassidy J, Eddleston J, Gunning K, Bellingan G, Patten M, Harrison D, Matching Michigan Collaboration & Writing Committee.
- Issue date: 2013 Feb
- National influences on catheter-associated bloodstream infection rates: practices among national surveillance networks participating in the European HELICS project.
- Authors: Hansen S, Schwab F, Behnke M, Carsauw H, Heczko P, Klavs I, Lyytikäinen O, Palomar M, Riesenfeld Orn I, Savey A, Szilagyi E, Valinteliene R, Fabry J, Gastmeier P
- Issue date: 2009 Jan
- [The effect of an intervention on rates of central vascular catheter-related bloodstream infection in intensive care units at the Hadassah Medical Center].
- Authors: Gross I, Block C, Benenson S, Cohen MJ, Brezis M
- Issue date: 2013 Jan
- Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: a reappraisal.
- Authors: Garrouste-Orgeas M, Timsit JF, Tafflet M, Misset B, Zahar JR, Soufir L, Lazard T, Jamali S, Mourvillier B, Cohen Y, De Lassence A, Azoulay E, Cheval C, Descorps-Declere A, Adrie C, Costa de Beauregard MA, Carlet J, OUTCOMEREA Study Group.
- Issue date: 2006 Apr 15