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dc.contributor.authorAxenov-Gibanov, Denis V
dc.contributor.authorVoytsekhovskaya, Irina V
dc.contributor.authorTokovenko, Bogdan T
dc.contributor.authorProtasov, Eugeniy S
dc.contributor.authorGamaiunov, Stanislav V
dc.contributor.authorRebets, Yuriy V
dc.contributor.authorLuzhetskyy, Andriy N
dc.contributor.authorTimofeyev, Maxim A
dc.date.accessioned2016-03-08T13:24:21Zen
dc.date.available2016-03-08T13:24:21Zen
dc.date.issued2016en
dc.identifier.citationActinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. 2016, 11 (2):e0149216 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid26901168en
dc.identifier.doi10.1371/journal.pone.0149216en
dc.identifier.urihttp://hdl.handle.net/10033/600890en
dc.description.abstractActinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
dc.language.isoenen
dc.titleActinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany, 3 Universität des Saarlandes–Pharmazeutische Biotechnologie, Saarbrucken, Germany.en
dc.identifier.journalPloS oneen
refterms.dateFOA2018-06-13T03:44:44Z
html.description.abstractActinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.


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