The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.
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AuthorsVázquez, Cristina L
Guzman, Carlos A
Wilson, Mark S
Gutierrez, Maximiliano G
MetadataShow full item record
AbstractSorting of luminal and membrane proteins into phagosomes is critical for the immune function of this organelle. However, little is known about the mechanisms that contribute to the spatiotemporal regulation of this process. Here, we investigated the role of the proneurotrophin receptor sortilin during phagosome maturation and mycobacterial killing. We show that this receptor is acquired by mycobacteria-containing phagosomes via interactions with the adaptor proteins AP-1 and GGAs. Interestingly, the phagosomal association of sortilin is critical for the delivery of acid sphingomyelinase (ASMase) and required for efficient phagosome maturation. Macrophages from Sort1(-/-) mice are less efficient in restricting the growth of Mycobacterium bovis BCG and M. tuberculosis. In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutrophils in their lungs and higher bacterial burden after infection with M. tuberculosis. Altogether, sortilin defines a pathway required for optimal intracellular mycobacteria control and lung inflammation in vivo.
CitationThe proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages. 2016, 6:29332 Sci Rep
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.
- Authors: Wähe A, Kasmapour B, Schmaderer C, Liebl D, Sandhoff K, Nykjaer A, Griffiths G, Gutierrez MG
- Issue date: 2010 Jul 15
- The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages.
- Authors: Sullivan JT, Young EF, McCann JR, Braunstein M
- Issue date: 2012 Mar
- Effective generation of reactive oxygen species in the mycobacterial phagosome requires K+ efflux from the bacterium.
- Authors: Butler RE, Cihlarova V, Stewart GR
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- Mycobacterium bovis BCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation.
- Authors: Sun J, Deghmane AE, Soualhine H, Hong T, Bucci C, Solodkin A, Hmama Z
- Issue date: 2007 Dec
- Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest.
- Authors: Fratti RA, Chua J, Deretic V
- Issue date: 2002 May 10