The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractT helper 17 (Th17) cells play an essential role in the clearance of extracellular pathogenic bacteria and fungi. However, this subset is critically involved in the pathology of many autoimmune diseases, e.g., psoriasis, multiple sclerosis, allergy, rheumatoid arthritis, and inflammatory bowel diseases in humans. Therefore, Th17 responses need to be tightly regulated in vivo to mediate effective host defenses against pathogens without causing excessive host tissue damage. Foxp3(+) regulatory T (Treg) cells play an important role in maintaining peripheral tolerance to self-antigens and in counteracting the inflammatory activity of effector T helper cell subsets. Although Th17 and Treg cells represent two CD4(+) T cell subsets with opposing principal functions, these cell types are functionally connected. In this review, we will first give an overview on the biology of Th17 cells and describe their development and in vivo function, followed by an account on the special developmental relationship between Th17 and Treg cells. We will describe the identification of Treg/Th17 intermediates and consider their lineage stability and function in vivo. Finally, we will discuss how Treg cells may regulate the Th17 cell response in the context of infection and inflammation, and elude on findings demonstrating that Treg cells can also have a prominent function in promoting the differentiation of Th17 cells.
CitationThe Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells. 2015, 136:99-129 Prog Mol Biol Transl Sci
AffiliationTWINCORE, Centre for Experimental and Clinical Medicine, 30625 Hannover, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.
- Authors: Coutinho A, Caramalho I, Seixas E, Demengeot J
- Issue date: 2005
- T helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organ transplantation.
- Authors: Askar M
- Issue date: 2014 Jun
- Interplay between pathogenic Th17 and regulatory T cells.
- Authors: Oukka M
- Issue date: 2007 Nov
- Balancing Inflammation: The Link between Th17 and Regulatory T Cells.
- Authors: Diller ML, Kudchadkar RR, Delman KA, Lawson DH, Ford ML
- Issue date: 2016